Protein Alignment Rip11 and RAB11FIP1

DIOPT Version :10

• Sequence 1: NP_573313.2
• Gene: Rip11 / 32850
• FlyBaseID: FBgn0027335
• Length: 832
• Species: Drosophila melanogaster
• Sequence 2: NP_001002814.2
• Gene: RAB11FIP1 / 80223
• HGNCID: 30265
• Length: 1283
• Species: Homo sapiens
• Alignment Length: 1296
• Identity: 265/1296 - (20%)
• Similarity: 414/1296 - (31%)
• Gaps: 508/1296 - (39%)

  Fly     1 MWSPTHCSVTVQRARGLLTKGKNGTNNCFVTIALGKEKYQTSVKDKAETSVNWNEECELKIPD-- 63
            :|||||..|||.:||||..||..||::.:..|.:|||||.|||.:::..:..|.||...::|.
Human    14 VWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFELPSLL 78

  Fly    64 ---QGNRAELTLTCLHRNNLGIDEFLGQATLPLNEMDVYD------RPRAKWFKLESKPGKEKKN 119
               ....|.|.||.|||..||:|:|||:|     |:|:.|      |.:.:|:||:||||  ||:
Human    79 SSGPAAAATLQLTVLHRALLGLDKFLGRA-----EVDLRDLHRDQGRRKTQWYKLKSKPG--KKD 136

  Fly   120 KERGELEVRIAFVVK--SGSLTDLSKKDKHKSSIGQLASSVGGSLLSIGNGEKRRGIKKLAGSLS 182
            |||||:||.|.|:..  :.|:.|||.|||.::..|:|...:.|.....|:......|.....|:.
Human   137 KERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGKNKDSGSDTASAIIPSTTPSVD 201

  Fly   183 S--KLHIRSKKKNQEAGADDSSS------FGGSFASLGTPNSSNGRGQNGGSGRRRGGQRAGEAD 239
            |  :..::.|||..:.....|.|      ...|.:.|.|........:.|..      |...:.|
Human   202 SDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGDF------QSQWDED 260

  Fly   240 PGVISEDEDEFVFDNLSHKSSGSS-------------------------------------LNIQ 267
            .   :|||.....|.:|||.:.|:                                     :|..
Human   261 D---NEDESSSASDVMSHKRTASTDLKQLNQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCINGN 322

  Fly   268 RIGLQPP----------PVGTPN---FTPRHPSPLLNNGVSGVGSGSAKGKQAVLPATLDEDASI 319
            .:.|:.|          |..:|:   |..:|......|..:|.....|:|........|.|.::.
Human   323 HVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTENLAAGSWKEPAEGGGLSSDRQLSESSTK 387

  Fly   320 DAEMEQLELDFSVRA-----------HARANANASASGNASTLPPPSKPPRIPLSQVDEQPAAGS 373
            |: ::.:.|. |.|.           .|.||:.|:.....|..|...:...:.|....:..|.||
Human   388 DS-LKSMTLP-SYRPAPLVSGDLRENMAPANSEATKEAKESKKPESRRSSLLSLMTGKKDVAKGS 450

  Fly   374 LEREKP-----KEK---------------PAE--VESDKDEWASKLYGGGKYLE----------- 405
             |.|.|     :||               |||  |...:.:.|:.:...|..|.
Human   451 -EGENPLTVPGREKEGMLMGVKPGEDASGPAEDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPE 514

  Fly   406 ------------IGSSNSLKRRSWEDRVP----------LPASVEEP---PPLHSSSSSSSSSSD 445
                        |.|..:.:.|:.:.|:.          ||:..:.|   |||.|||..:|..|:
Human   515 AEPESKSEPRPPISSPRAPQTRAVKPRLEVSPEAQPTARLPSPTDSPSSLPPLPSSSGQASVPSE 579

  Fly   446 ----SDDDDEKPPQ-----AAPPPVPVPASLPV-------------------PSAAASTASADPV 482
                :|....:.|.     ::|...|:..|.|:                   |.|...|.|..||
Human   580 LGHGADTQSSESPSVFSSLSSPIAAPISTSTPIESWPLVDRGQAKSEGPPLLPKAELQTESLTPV 644

  Fly   483 VATSS----SLFSPDVEHRNFDTFNASFAKYEQRNSTAIFADEPELEDLTVELEKPAPTPTARPK 543
            ..:.|    |||.......|..|.::...:..:..:      |.....|.:|...|....|.|.:
Human   645 PNSGSSALGSLFKQPSFPANKGTEDSLMGRTRETGT------EKNTSSLELEESLPEQPETGRQE 703

  Fly   544 PQ----PRATADLRAEEEKAKE-------------EAARQLRAEEDARLEAEL-RLNEERLREEE 590
            .:    |....|......:|:|             ....:|.|..|..||::. .|.|.:.|:..
Human   704 EELPRFPCKKQDYSPSSGEAQEVPFALSLSSDGAVSPVGELAAGGDRDLESQAGSLVESKARDAA 768

  Fly   591 E----------------AMQRELEE--------EKERQKQLQMDEQ------------------- 612
            |                :|.|:|||        :|:.:|::...||
Human   769 EEVAPPLPMGASVPSIDSMMRKLEEMGLNLRKDQKKTKKRVSFSEQLFTEEAVAGAALLVEGHSS 833

  Fly   613 ------------------QRREAKRWEEDQR---------------------LLSFAKRSTS--- 635
                              :..|:...|:.:|                     ||...:.|.|
Human   834 CPQELNPAWSVAGNASDGEPPESPHAEDSERESVTTPGPATCGAPASPADHLLLPSQEESFSEVP 898

  Fly   636 -----------------------------------LEEPVPEKQ--------------------- 644
                                               |.:|:.:.|
Human   899 MSEASSAKDTPLFRMEGEDALVTQYQSKASDHEGLLSDPLSDLQLVSDFKSPIMADLNLSLPSIP 963

  Fly   645 ELKHERELVAKQEPE-------------KTLDTAE---------PE------------------- 668
            |:..:.|.:.:.|.:             .|||...         ||
Human   964 EVASDDERIDQVEDDGDQVEDDGETAKSSTLDIGALSLGLVVPCPERGKGPSGEADRLVLGEGLC 1028

  Fly   669 ------PEHNFLTPEQSPKEFQTNGSGSGSGERWEKRLGKFKYGNKRDKYNNDN---------DS 718
                  |:.:...|.:...||..:....|.....:|:|.....|.:.....|.:         |:
Human  1029 DFRLQAPQASVTAPSEQTTEFGIHKPHLGKSSSLDKQLPGPSGGEEEKPMGNGSPSPPPGTSLDN 1093

  Fly   719 NSPSPKSTERIIIGHE-KSGSHADRRSEISAQLAKK--YEGKS--------REELM--------- 763
            ..|||..:|...:.|. .|.:|:|.....:|:..||  .||.:        |:.|:
Human  1094 PVPSPSPSEIFPVTHSFPSSAHSDTHHTSTAESQKKATAEGSAGRVENFGKRKPLLQAWVSPSET 1158

  Fly   764 ----------------------------------------LIANGMENEALLQRQ---------- 778
                                                    :|:..:.||.::::.
Human  1159 HPVSAQPGAGTGSAKHRLHPVKPMNAMATKVANCSLGTATIISENLNNEVMMKKYSPSDPAFAYA 1223

  Fly   779 -----------------------RVKELEDYLDNLLLRVMETHPKILQNPYSRTTSAKRYG 816
                                   :|:|||||:||||:||||..|.||:.|   |...|:.|
Human  1224 QLTHDELIQLVLKQKETISKKEFQVRELEDYIDNLLVRVMEETPNILRIP---TQVGKKAG 1281

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rip11	NP_573313.2	C2_Rab11-FIP_classI	7..130	CDD:176064	58/133 (44%)
		RBD-FIP	758..805	CDD:462805	22/136 (16%)
RAB11FIP1	NP_001002814.2	C2_Rab11-FIP_classI	20..147	CDD:176064	58/133 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	161..281		29/128 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	330..727		79/405 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	741..782		9/40 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	835..913		7/77 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	969..993		2/23 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1037..1141		22/103 (21%)
		Necessary for interaction with RAB4A and RAB11A, subcellular location and endosomal recycling. /evidence=ECO:0000269|PubMed:15280022	1219..1283		21/66 (32%)
		RBD-FIP	1226..1273	CDD:462805	17/46 (37%)