DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rip11 and Rab11fip1

DIOPT Version :9

Sequence 1:	NP_573313.2	Gene:	Rip11 / 32850	FlyBaseID:	FBgn0027335	Length:	832	Species:	Drosophila melanogaster
Sequence 2:	XP_036010246.1	Gene:	Rab11fip1 / 75767	MGIID:	1923017	Length:	1170	Species:	Mus musculus

Alignment Length:	837	Identity:	212/837 - (25%)
Similarity:	320/837 - (38%)	Gaps:	190/837 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWSPTHCSVTVQRARGLLTKGKNGTNNCFVTIALGKEKYQTSVKDKAETSVNWNEECELKIPD-- 63
            ||||||..|||.:||||..||..||::.:..|.:|||||.|||.:::..:..|.||...::|.
Mouse    14 MWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFELPPLL 78

  Fly    64 -----QGNRAELTLTCLHRNNLGIDEFLGQATLPLNEMDVYDRPRAK--WFKLESKPGKEKKNKE 121
                 ....|.|.||.|||..||:|:|||:|.:.|.|:. .|:.|.|  |:.|:||||  ||:||
Mouse    79 SSGAAPAAAATLQLTVLHRALLGLDKFLGRAEVDLRELH-RDQGRRKKQWYTLKSKPG--KKDKE 140

  Fly   122 RGELEVRIAFVVK--SGSLTDLSKKDKHKSSIGQLASSVGGSLLSIGNGEKRRGIKKLAGSLSSK 184
            |||:||.|.|:..  :.|:.|||.|||.::..|:|...:.|......:......:..:..|:.|.
Mouse   141 RGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGKNKDSASDTASAIVPSVTPSVDSD 205

  Fly   185 LHIRSKKKNQEA--------GADDSSSFGGSFASLGTPNSSNGRGQNGGSGRRRGGQRAGEADPG 241
            ....||.|.:::        .:...:....|.:.|.|..|.        ....|.|....:.|..
Mouse   206 DESFSKDKKKKSKIKTLFSKSSLQKTPLSQSMSVLPTSKSD--------KVLLRAGDFQSQWDDD 262

  Fly   242 VISEDEDEFVFDNLSHKSSGSSLNIQRIGLQPPPVGTPNFT-PRHPSPLLNNGVSGVGSGSAKGK 305
            . .|||.....|.:|||.:.|:      ..||   ...||: |:      ..|:|.:| |.....
Mouse   263 A-HEDESSSASDVMSHKRTSST------DQQP---NQSNFSLPK------KEGLSFLG-GLRSKN 310

  Fly   306 QAVLPATLDEDASIDAEMEQLELDFSVRAHARANANA----------SASGNASTLPP------- 353
            .::..:|:..:.: ...|||.|....:|..:.:|:.:          |::.|.:...|
Mouse   311 DSLSRSTVCINGN-HVYMEQPEARSEIRESSPSNSPSPQGFRRKHLFSSTENLAARSPKEPGEGG 374

  Fly   354 -PSKPPRIPLSQVDEQPAAGSLEREKP--------KEKPAEVESDKDEWASKLYGGGK----YLE 405
             .|...|:..|...:...:.||...:|        ...||.||:.::...||.....|    .|.
Mouse   375 GTSSDRRLSDSSTKDSMKSMSLPSYRPLTSGDNRESMSPANVEAARETKDSKKQESKKSSLLSLV 439

  Fly   406 IGSSNSLKRRSWEDRVPLP-----------ASVE------------EPPPLHSSSSSSSSSSDSD 447
            .|..::..:.|  :..|||           |.||            |...|..:|...||.:..:
Mouse   440 TGKRDAAAKGS--ESEPLPTVSEKEKERKGALVEAQLREEDLMRRPEKDALPVASQWGSSLNPFE 502

  Fly   448 DDDEKPPQA-----APPPVPVPAS-LPVPSAAASTASADPVVATSSSLFSPDVEHRNFDTFNASF 506
            |.....|.|     :.|..||||: :|...|........|.....:.|.|||         :|.|
Mouse   503 DVQISDPGATTESRSEPKPPVPAARVPQTKAVKPRLEVSPEAQPKARLPSPD---------SALF 558

  Fly   507 AKYE------------QRNSTAIFADEPELEDLTVELEKPAPTPT-ARPKPQPRATAD------- 551
            |.:.            :.:|...|::.|........|..|..|.| ..|.|..:..||
Mouse   559 APFPSDSIQPPVLSDLRCDSETQFSESPSASSFLSPLAAPISTSTPVEPWPTGQGEADAEKPSLL 623

  Fly   552 LRA-------------------EE-----EKAKEEAARQLRAEEDARLEAELRLNE-----ERLR 587
            |||                   |:     .|..|||:...|.|..:....:..:.|     :.:.
Mouse   624 LRAVPSLTPAANTGSSASGSPCEQLPTPVRKGTEEASGDTRKEAGSDESGKTLMTECVSSVDNVH 688

  Fly   588 E------EEEAMQRELEEE-----KERQKQLQMDEQ----QRREAKRWEEDQRLLSFAKRSTSLE 637
            :      .|||....||:|     :..||...|.:.    |::..||....::|  |.:..|  |
Mouse   689 DGGMTTAGEEAAPPLLEDEASSFHRIAQKHEGMHQNASGGQKKGKKRVSFSEQL--FVEEET--E 749

  Fly   638 EPVPEKQELKHERELVAKQEP--EKTLDTAEPEPEHNFLT-PEQSPKEFQTNGSGSG 691
            .|...::|.:...:.:.::.|  ...|....||..|...| .|....|.|.|.|..|
Mouse   750 GPTRLEEEDRGHAQQLTQEGPVAGSVLRAGSPESPHTEGTGQEPVTAEAQPNISSEG 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rip11	NP_573313.2	C2_Rab11-FIP_classI	7..130	CDD:176064	58/131 (44%)
Rip11	NP_573313.2	RBD-FIP	758..805	CDD:255374
Rab11fip1	XP_036010246.1	C2_Rab11-FIP_classI	20..149	CDD:176064	58/131 (44%)
Rab11fip1	XP_036010246.1	PHA03247	<489..651	CDD:223021	36/170 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833996
Domainoid	1	1.000	77	1.000	Domainoid score	I8825
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	176	1.000	Inparanoid score	I4036
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D259412at33208
OrthoFinder	1	1.000	-	-		FOG0002878
OrthoInspector	1	1.000	-	-		otm43646
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15746
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X973
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.960