DRSC/TRiP Functional Genomics Resources

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Protein Alignment Rip11 and Rab11fip2

DIOPT Version :10

Sequence 1:NP_573313.2 Gene:Rip11 / 32850 FlyBaseID:FBgn0027335 Length:832 Species:Drosophila melanogaster
Sequence 2:NP_001028344.2 Gene:Rab11fip2 / 74998 MGIID:1922248 Length:529 Species:Mus musculus


Alignment Length:626 Identity:155/626 - (24%)
Similarity:238/626 - (38%) Gaps:184/626 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 WSPTHCSVTVQRARGLLTKGKNGTNNCFVTIALGKEKYQTSVKDKAETSVNWNEECELKIPD--- 63
            |.|||..|||.:|:.|..|||:|||:.:..|.||||||.|||.:|....| |.||...::|.   
Mouse    10 WFPTHVQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPV-WKEEASFELPGLLM 73

  Fly    64 QGNRAE--LTLTCLHRNNLGIDEFLGQATLPLNEMDVYD---RPRAKWFKLESKPGKEKKNKERG 123
            ||:..:  |.|..:||:.:|:|:||||..:.||  |:::   |.:.:||:||||.||..||  ||
Mouse    74 QGSPEKYILFLIVMHRSLVGLDKFLGQVAINLN--DIFEDKQRRKTEWFRLESKQGKRIKN--RG 134

  Fly   124 ELEVRIAFVVK--SGSLTDLSKKDKHKSSIGQLASSVGGSLLSIGNGEKRRGIKKLAGSLSSKLH 186
            |::|.|.|:..  :.|:.|||.|||.:|...:|...:.|                          
Mouse   135 EIKVNIQFMRNNMTASMFDLSMKDKTRSPFAKLKDKMKG-------------------------- 173

  Fly   187 IRSKKKNQEAGADDSSSF-GGSFASLGTPNSSNGRGQNGGSGRR---RGGQRAGEADPGVISEDE 247
                :|:....:|.||:. ..:......|..|:|..|.....::   .|.||...|         
Mouse   174 ----RKSDGVFSDTSSAIVPSTHMPDANPEFSSGEMQMKSKPKKPFLLGPQRLSSA--------- 225

  Fly   248 DEFVFDNLSHKSS---GSSLNIQRIGLQPPPVGTPNFTPRHPSPLLNNGVSGVG----SGSAKGK 305
                     |..|   ||.|:.::  |:...||        |:.||:..:...|    |||.|..
Mouse   226 ---------HSMSDLTGSHLSSEK--LKSSTVG--------PTHLLSRQIDSFGVVPESGSLKSP 271

  Fly   306 Q----AVLPATLDEDASIDAEMEQLELDFSVRAHARANANASASGNASTLPPPSKPPRIPLSQVD 366
            .    :...:.|::..||   :::.|..|..::....|..||.....:|||....|         
Mouse   272 HRRTLSFDTSKLNQPGSI---VDEGEHSFGRQSDPFTNVTASLPQKFATLPRKKNP--------- 324

  Fly   367 EQPAAGSLEREKPKEKPAEVESDKDEWASKLYGGGKYLEIGSSNSLKRR---SWEDRVPLPASVE 428
                               .|...:.|.|.:....|.:|:...:..::|   |..:||.......
Mouse   325 -------------------FEESSEPWDSSMNLFSKPIEVRKESKREKREKVSLFERVTGKRDSR 370

  Fly   429 EPPPLHSSSSSSSSSSDSDDDDEKPPQAAPPPVPVPASLPVPSAAASTASADPVVATSSSLFSPD 493
            .|..|::..|.|                       |..|..|||                 ||  
Mouse   371 RPDKLNNGGSDS-----------------------PCDLKSPSA-----------------FS-- 393

  Fly   494 VEHRNFDTFNASFAKYEQRNSTAIFADEPELEDLTVELEKPAPTPTARPKPQPRATADLRAEEEK 558
             |:|.      .:.:||..|            ..|.:.......|::.....|.::.|||...:.
Mouse   394 -ENRQ------DYFEYESTN------------PFTAKFRASTIMPSSSFHVNPTSSEDLRKIPDN 439

  Fly   559 AKEEAARQLRAEEDARLEAELRLNEERLREEEEAMQRELEE 599
            ...:|....|:.....:..||..::|.||.::..: ||||:
Mouse   440 NPFDATAGYRSLTYEEVLQELVKHKELLRRKDTHI-RELED 479

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Rip11NP_573313.2 C2_Rab11-FIP_classI 7..130 CDD:176064 57/130 (44%)
RBD-FIP 758..805 CDD:462805
Rab11fip2NP_001028344.2 C2_Rab11-FIP_classI 15..141 CDD:176064 57/130 (44%)
Necessary for its cellular translocation to the plasma membrane. /evidence=ECO:0000250 15..102 39/87 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 174..231 14/74 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 263..287 5/23 (22%)
NPF 1. /evidence=ECO:0000250 323..325 1/29 (3%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 347..390 10/65 (15%)
NPF 2. /evidence=ECO:0000250 406..408 1/13 (8%)
NPF 2. /evidence=ECO:0000250 440..442 0/1 (0%)
RBD-FIP 452..499 CDD:462805 9/29 (31%)
Blue background indicates that the domain is not in the aligned region.

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