DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rip11 and Rab11fip2

DIOPT Version :9

Sequence 1:	NP_573313.2	Gene:	Rip11 / 32850	FlyBaseID:	FBgn0027335	Length:	832	Species:	Drosophila melanogaster
Sequence 2:	NP_001100917.2	Gene:	Rab11fip2 / 308003	RGDID:	1308538	Length:	512	Species:	Rattus norvegicus

Alignment Length:	839	Identity:	176/839 - (20%)
Similarity:	263/839 - (31%)	Gaps:	364/839 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WSPTHCSVTVQRARGLLTKGKNGTNNCFVTIALGKEKYQTSVKDKAETSVNWNEECELKIPD--- 63
            |.|||..|||.:|:.|..|||:|||:.:..|.||||||.|||.:|....| |.||...::|.
  Rat    10 WFPTHVQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPV-WKEEASFELPGLLM 73

  Fly    64 QGNRAE--LTLTCLHRNNLGIDEFLGQATLPLNEMDVYD---RPRAKWFKLESKPGKEKKNKERG 123
            |||..:  |.|..:||:.:|:|:||||..:.||  |:::   |.:.:||:||||.||..||  ||
  Rat    74 QGNPEKYILFLIVMHRSLVGLDKFLGQVAINLN--DIFEDKQRRKTEWFRLESKQGKRIKN--RG 134

  Fly   124 ELEVRIAFVVK--SGSLTDLSKKDKHKSSIGQLASSVGGSLLSIGNGEKRRGIKKLAGSLSSKLH 186
            |::|.|.|:..  :.|:.|||.|||.:|...:|...:.|
  Rat   135 EIKVNIQFMRNNMTASMFDLSMKDKTRSPFAKLKDKMKG-------------------------- 173

  Fly   187 IRSKKKNQEAGADDSSSF-GGSFASLGTPNSSNGRGQNGGSGRR---RGGQRAGEADPGVISEDE 247
                :|:....:|.||:. ..:......|..|:|..|.....::   .|.||...|
  Rat   174 ----RKSDGVFSDTSSAIVPSTHMPDANPEFSSGEMQMKSKPKKPFLLGPQRLSSA--------- 225

  Fly   248 DEFVFDNLSHKSS---GSSLNIQRIGLQPPPVGTPNFTPRHPSPLLNNGVSGVG----SGSAKGK 305
                     |..|   ||.|:.::  |:...||        |:.||::.::..|    |||.|..
  Rat   226 ---------HSMSDLTGSHLSSEK--LKSSTVG--------PTHLLSHQINSFGVVPESGSLKSP 271

  Fly   306 Q----AVLPATLDEDASIDAEMEQLELDFSVRAHARANANASASGNASTLPPPSKPPRIPLSQVD 366
            .    :...:.|::..||..|.|..   |..::....|..||.....:|||....|
  Rat   272 HRRTLSFDTSKLNQPGSIVDEGEHC---FGRQSDPFTNVTASLPQKFATLPRKKNP--------- 324

  Fly   367 EQPAAGSLEREKPKEKPAEVESDKDEWASKLYGGGKYLEIGSSNSLKRRSWEDRVPLPASVEEPP 431
                               .|...:.|.|......|.:|:...:..::|   ::|.|...|....
  Rat   325 -------------------FEESSEPWDSSTNLFSKPIEVRKESKREKR---EKVSLFERVTGKR 367

  Fly   432 PLHSSSSSSSSSSDSDDDDEKPPQAAPPPVPVPASLPVPSAAASTASADPVVATSSSLFSPDVEH 496
            ....|...::..|||                 |..|..|||
  Rat   368 DSRRSDKLNNGGSDS-----------------PCDLKSPSA------------------------ 391

  Fly   497 RNFDTFNASFAKYEQRNSTAIFADEPELEDLTVELEKPAPTPTARPKPQPRATADLRAEEEKAKE 561
                 ||.:...|.:..||..|         |.:.......|::.....|.::.|||...:....
  Rat   392 -----FNENRQDYFEYESTNPF---------TAKFRASTIMPSSSFHMNPTSSDDLRKIPDSNPF 442

  Fly   562 EAARQLRAEEDARLEAELRLNEERLREEEEAMQRELEEEKERQKQLQMDEQQRREAKRWEEDQRL 626
            :|
  Rat   443 DA--------------------------------------------------------------- 444

  Fly   627 LSFAKRSTSLEEPVPEKQELKHERELVAKQEPEKTLDTAEPEPEHNFLTPEQSPKEFQTNGSGSG 691
             :...||.:.||.:   |||...:||:.::      ||
  Rat   445 -TAGYRSLTYEEVL---QELVKHKELLRRK------DT--------------------------- 472

  Fly   692 SGERWEKRLGKFKYGNKRDKYNNDNDSNSPSPKSTERIIIGHEKSGSHADRRSEISAQLAKKYEG 756

  Rat   473 ----------------------------------------------------------------- 472

  Fly   757 KSREELMLIANGMENEALLQRQRVKELEDYLDNLLLRVMETHPKILQNPYSRTTSAKRY 815
                                  .::|||||:||||:||||..|.||:.||..:..|.::
  Rat   473 ----------------------HIRELEDYIDNLLVRVMEETPSILRVPYEPSRKAGKF 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rip11	NP_573313.2	C2_Rab11-FIP_classI	7..130	CDD:176064	58/130 (45%)
Rip11	NP_573313.2	RBD-FIP	758..805	CDD:255374	16/46 (35%)
Rab11fip2	NP_001100917.2	C2_Rab11-FIP_classI	15..141	CDD:176064	58/130 (45%)
Rab11fip2	NP_001100917.2	RBD-FIP	452..499	CDD:255374	25/169 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337536
Domainoid	1	1.000	79	1.000	Domainoid score	I8482
eggNOG	1	0.900	-	-		E1_2C75I
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	171	1.000	Inparanoid score	I4021
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D259412at33208
OrthoFinder	1	1.000	-	-		FOG0002878
OrthoInspector	1	1.000	-	-		otm45722
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15746
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X973
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.860