Protein Alignment Rip11 and RAB11FIP2

DIOPT Version :9

• Sequence 1: NP_573313.2
• Gene: Rip11 / 32850
• FlyBaseID: FBgn0027335
• Length: 832
• Species: Drosophila melanogaster
• Sequence 2: NP_001317096.1
• Gene: RAB11FIP2 / 22841
• HGNCID: 29152
• Length: 532
• Species: Homo sapiens
• Alignment Length: 839
• Identity: 184/839 - (21%)
• Similarity: 276/839 - (32%)
• Gaps: 344/839 - (41%)

  Fly     2 WSPTHCSVTVQRARGLLTKGKNGTNNCFVTIALGKEKYQTSVKDKAETSVNWNEECELKIPD--- 63
            |.|||..|||.:|:.|..|||:|||:.:..|.||||||.|||.:|....| |.||...::|.
Human    10 WFPTHVQVTVLQAKDLKPKGKSGTNDTYTIIQLGKEKYSTSVAEKTLEPV-WKEEASFELPGLLI 73

  Fly    64 QGNRAE--LTLTCLHRNNLGIDEFLGQATLPLNEMDVYD---RPRAKWFKLESKPGKEKKNKERG 123
            ||:..:  |.|..:||:.:|:|:||||..:.||  |:::   |.:.:||:||||.||..||  ||
Human    74 QGSPEKYILFLIVMHRSLVGLDKFLGQVAINLN--DIFEDKQRRKTEWFRLESKQGKRIKN--RG 134

  Fly   124 ELEVRIAFVVK--SGSLTDLSKKDKHKSSIGQLASSVGGSLLSIGNGEKRRGIKKLAGSLSSKLH 186
            |::|.|.|:..  :.|:.|||.|||.:|...:|...:.|
Human   135 EIKVNIQFMRNNMTASMFDLSMKDKTRSPFAKLKDKMKG-------------------------- 173

  Fly   187 IRSKKKNQEAGADDSSSFGGSFASLGTPNSSNGRGQNGGSGRRRGGQRAGEADPGVI---SEDED 248
                :||....:|.||:.   ..|...|::::                  |...|.|   |:.:.
Human   174 ----RKNDGTFSDTSSAI---IPSTHMPDANS------------------EFSSGEIQMKSKPKK 213

  Fly   249 EFVF--DNLSHKSSGSSLNIQRIGLQPPPVGTPNFTPRHPSPLLNNGVSGVG----SGSAKGKQA 307
            .|:.  ..||...|.|.|:...:..:....||...|  |   ||.:.:...|    |||.|....
Human   214 PFLLGPQRLSSAHSMSDLSGSHMSSEKLKAGTIGQT--H---LLGHQLDSFGTVPESGSLKSPHR 273

  Fly   308 VLPATLDEDAS----IDAEMEQLELDFSVRAHARANANASASGNASTLPPPSKPPRIPLSQVDEQ 368
               .||..|.|    .|:.:::.||.|..:.....|..||.....:|||....|
Human   274 ---RTLSFDTSKMNQPDSIVDEGELCFGRQNDPFTNVTASLPQKFATLPRKKNP----------- 324

  Fly   369 PAAGSLEREKPKEKPAEVESDKDEWASKLYGGGKYLEIGSSNSLKRRSWEDRVPLPASVEEPPPL 433
                             .|...:.|.|.:....|.:||...|..::|   ::|.|...|......
Human   325 -----------------FEESSETWDSSMNLFSKPIEIRKENKREKR---EKVSLFERVTGKKDS 369

  Fly   434 HSSSSSSSSSSDSDDDDEKPPQAAPPPVPVPASLPVPSAAASTASADPVVATSSSLFSPDVEHRN 498
            ..|...::..|||                 |..|..|:|.:....                ::.:
Human   370 RRSDKLNNGGSDS-----------------PCDLKSPNAFSENRQ----------------DYFD 401

  Fly   499 FDTFNASFAKYEQRNSTAIFADEPELEDLTVELEKPAPTPTARPKPQPRATADLRAEEEKAKEEA 563
            :::.|...||:...|.                      .|::|......|.|:.|.
Human   402 YESTNPFTAKFRASNI----------------------MPSSRNTLLTPAVAEWRG--------- 435

  Fly   564 ARQLRAEEDARLEAELRLNEERLREEEEAMQRELEEEKERQKQLQMDEQQRREAKRWEEDQRLLS 628
                                                                 :.||.|     .
Human   436 -----------------------------------------------------SLRWAE-----L 442

  Fly   629 FAKRSTSLEEPVPEKQELKHERELVAKQEPEKTLDTAEPEPEHNFLTPEQSPKEFQTNGSGSGSG 693
            |....||.|:          .|::                       |:.:|.: .|.|..|.:.
Human   443 FHMSPTSNED----------LRKI-----------------------PDSNPFD-ATAGYRSLTY 473

  Fly   694 ERWEKRLGKFKYGNKRDKYNNDNDSNSPSPKSTERIIIGHEKSGSHADRRSEISAQLAKKYEGKS 758
            |                                                  |:..:|.|..|
Human   474 E--------------------------------------------------EVLQELVKHKE--- 485

  Fly   759 REELMLIANGMENEALLQRQ--RVKELEDYLDNLLLRVMETHPKILQNPYSRTTSAKRY 815
                           ||:|:  .::|||||:||||:||||..|.||:.||..:..|.::
Human   486 ---------------LLRRKDTHIRELEDYIDNLLVRVMEETPSILRVPYEPSRKAGKF 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rip11	NP_573313.2	C2_Rab11-FIP_classI	7..130	CDD:176064	57/130 (44%)
		RBD-FIP	758..805	CDD:255374	19/48 (40%)
RAB11FIP2	NP_001317096.1	C2_Rab11-FIP_classI	15..141	CDD:176064	57/130 (44%)
		RBD-FIP	472..519	CDD:255374	24/114 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143769
Domainoid	1	1.000	77	1.000	Domainoid score	I8859
eggNOG	1	0.900	-	-		E1_2C75I
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	167	1.000	Inparanoid score	I4163
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D259412at33208
OrthoFinder	1	1.000	-	-		FOG0002878
OrthoInspector	1	1.000	-	-		otm41598
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15746
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5052
SonicParanoid	1	1.000	-	-		X973
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.890