DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rip11 and rab11fip5

DIOPT Version :9

Sequence 1:	NP_573313.2	Gene:	Rip11 / 32850	FlyBaseID:	FBgn0027335	Length:	832	Species:	Drosophila melanogaster
Sequence 2:	XP_031760760.1	Gene:	rab11fip5 / 100036623	XenbaseID:	XB-GENE-481066	Length:	1452	Species:	Xenopus tropicalis

Alignment Length:	964	Identity:	226/964 - (23%)
Similarity:	359/964 - (37%)	Gaps:	258/964 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WSPTHCSVTVQRARGLLTKGKNGTNNCFVTIALGKEKYQTSVKDKAETSVNWNEECELKIP---- 62
            |.|||..||:.:||||..|||:||::.:..|.:|:|||.|||.:|:..|..|.|||..::.
Frog    11 WLPTHVQVTILQARGLRAKGKHGTSDAYTLIQIGREKYSTSVVEKSPGSPEWKEECSFELAPGAL 75

  Fly    63 DQGNRAELTLTCLHRNNLGIDEFLGQATLPLNEMDVYDRPRA---KWFKLESKPGKEKKNKERGE 124
            ::....||.||.:||..:|:|:||||.|:||..  ||...|:   :|:||.||||  ||.|||||
Frog    76 ERAENCELQLTVMHRALIGMDQFLGQVTIPLQH--VYQEGRSQRNQWYKLRSKPG--KKEKERGE 136

  Fly   125 LEVRIAFVVK--SGSLTDLSKKDKHKSSIGQL-------------------ASSVGGSLLSIGNG 168
            ::|.|.|...  :.|:.|||.|||.|:..|:|                   .||||  .|...:.
Frog   137 IQVSIQFTRNNLTASMFDLSIKDKPKTPFGKLKDKMKVKKLFDMESSSAIVPSSVG--RLDSDDE 199

  Fly   169 EKRRGIKKLAGSLSSKLHIRS-KKKNQEAGADDS-SSFGGSFA-----SLGTPNSSNGRGQNGGS 226
            ::::...|.|..|..:|...| .:.|...|:|.: ||..|:.|     |:..|:..........|
Frog   200 DEKKPKSKAALFLKGRLRKNSLTRSNTSLGSDSTISSTSGTVANNAGISIVLPDPGKKPASRNSS 264

  Fly   227 GRRRGGQRAGEADPGVISEDEDEFVFDNLSHKSSGSSLNIQRIGLQPPPVGTPNFTPRHPSPLLN 291
            .......::.||.|             .::||.:.|. .:.::.:.|.|....|..|: .||:..
Frog   265 LSVEPSAQSSEASP-------------RMTHKRAFSD-EVSQLSIFPEPKVVQNLKPK-GSPISK 314

  Fly   292 NGVSGVGSG----------------------------SAKGKQAVLP-ATLDEDASIDAEMEQLE 327
            :.|...||.                            |.|.:::.:| |...:..|:|   :|.:
Frog   315 SSVCINGSHVYTETPLPKPLPSPLEKLPPVSRSFQNISKKAEESSIPGAATGQLHSLD---KQEK 376

  Fly   328 LDFSVRAHARANANASASGNASTLPPPSKPPRI--PL------SQVDEQPAAGSLEREKPKE--- 381
            ...:....|:......|......:...|||.:|  |:      .:|..|..||. |.:|||.
Frog   377 KPIASPTPAQEEVKVPAKSKNDEIHKESKPVQITSPMVFSEEPPKVKAQDGAGK-EEKKPKANLF 440

  Fly   382 ----------KPA---EVESDKDEWASKLYGGGKYLE-----------IGSSNSLKRRS--WEDR 420
                      :||   .|.|::.......:|.....|           |.:|.:.:|.|  .|:.
Frog   441 HHDSGTKIHVEPAHQTSVASEEKAKPGSWFGSKDPKETPQKPSFPSGSIATSEAAERGSSLVEEH 505

  Fly   421 VPL---PASVEEPPPLHSSSSSSSSSSDSDDDDEKPPQAAPPPVPVPASLPVPSAAASTASADPV 482
            .||   ||......|||...|:|.::           .|.|..|.:.:..|..|...:....:..
Frog   506 SPLAFSPAPEVHKKPLHQEKSASRNN-----------LAEPHEVSLASRNPYRSPVNTAELEEEF 559

  Fly   483 VATSSSLFSPDVE-----------HRNFD-----------TFNASFAKYEQRNSTAI-------F 518
            .|.:||...|.:|           |.:.|           :.|...:...|::...:       .
Frog   560 DAFASSRLQPAIENPTPTEANRKSHLDNDGDLSCPGHYIQSINIQISNAAQKSDRTVGVLPRLLT 624

  Fly   519 ADEPELEDLTVELEKPA------------PTPTARPKPQPRATADLRAEEEKA------------ 559
            :..||::.:|.:...||            |..:||.:|: .....|.:::.||
Frog   625 STRPEVKAITKDELFPASLQSSDHKLHISPAESARIQPK-EEQCSLTSDQGKAWSLPDKWKTGDG 688

  Fly   560 ------KEEAARQLRAEEDARLEAELRLNEERLREEEEAMQRELEEEKERQKQLQMDEQQRREAK 618
                  :..||:::   .|........||:  .:...|::...|..|.::....|:.|.:.:.|.
Frog   689 NWWHSNEHSAAKEV---SDMYRGYNPELNQ--YKPLPESISSRLPSESDKDGYSQIHETEHKIAT 748

  Fly   619 RWE---EDQRLLSFAK-RSTSLEEPVPEKQELKHERELVAKQEPEKTLDTAEPEPEHNF------ 673
            ...   |:..:..|.. ..|.|..|||:.:. :|...::.:.|   |.|........:|
Frog   749 VSPLILEEHAITRFTDLHKTPLPNPVPQSKS-RHSLSIIPEDE---TTDQVGHHSSTSFAGDLHI 809

  Fly   674 ---------LTPEQSPKEFQTNG------SGSGSGERW---EKRLGKFKYGNKRDKYNNDNDSNS 720
                     .|...|...|..:|      ||||..:.:   |.:|           .:...|..|
Frog   810 STEFKEGATYTDHNSNSVFTVSGQETLPISGSGESKEFIEPETKL-----------LDISTDLES 863

  Fly   721 PSPKSTERIIIGHEKSGSHADRRSEISAQLAKKYEGKSREELMLIANGMENEAL 774
            ..|....:.::..||:      ..|...||..|....||..|.|    .|||.:
Frog   864 ARPSKPPQQVLPQEKT------NDENHKQLQNKDNDVSRTSLKL----SENETV 907

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rip11	NP_573313.2	C2_Rab11-FIP_classI	7..130	CDD:176064	58/129 (45%)
Rip11	NP_573313.2	RBD-FIP	758..805	CDD:255374	7/17 (41%)
rab11fip5	XP_031760760.1	C2_Rab11-FIP_classI	16..142	CDD:176064	58/129 (45%)
		PTZ00249	<1210..>1343	CDD:140276
		RBD-FIP	1397..1444	CDD:401421
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	90	1.000	Domainoid score	I7659
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	191	1.000	Inparanoid score	I3756
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D259412at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48812
Panther	1	1.100	-	-	O	PTHR15746
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5052
SonicParanoid	1	1.000	-	-		X973
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.190