DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Bx and PDLIM7

DIOPT Version :9

Sequence 1:NP_001259687.1 Gene:Bx / 32846 FlyBaseID:FBgn0265598 Length:424 Species:Drosophila melanogaster
Sequence 2:NP_005442.2 Gene:PDLIM7 / 9260 HGNCID:22958 Length:457 Species:Homo sapiens


Alignment Length:208 Identity:45/208 - (21%)
Similarity:73/208 - (35%) Gaps:53/208 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 PNPNGNGNVVNVVNSGGAGGGNNGNGNV------------QSIAAAANNNNNNNNNGSQLCAGCG 96
            |.|..:...:....:||..||.:.||..            :.:.|..:..:..    ..:|:.||
Human   252 PTPLQSRTSIVQAAAGGVPGGGSNNGKTPVCHQCHKVIRGRYLVALGHAYHPE----EFVCSQCG 312

  Fly    97 KHIQD------------------RY--------------LLRALDMLWHEDCLKCGCCDCRLGEV 129
            |.:::                  ||              ::.||.|.||..|..|..|...:.  
Human   313 KVLEEGGFFEEKGAIFCPPCYDVRYAPSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIR-- 375

  Fly   130 GSTLYTKGNLMLCKRDYLRLFGNTGYCAACSKVIPAFEMVMRARTNVYHLECFACQQCNHRFCVG 194
            ....|.:..:..|:|||.::||..  |..|...|.|.:..:.|....:|..||.|..|.... .|
Human   376 NRAFYMEEGVPYCERDYEKMFGTK--CHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINL-EG 437

  Fly   195 DRFYLCENKILCE 207
            ..||..:::.||:
Human   438 KTFYSKKDRPLCK 450

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BxNP_001259687.1 LIM1_LMO1_LMO3 92..146 CDD:188774 17/85 (20%)
LIM2_dLMO 156..210 CDD:188776 15/52 (29%)
PDLIM7NP_005442.2 PDZ_signaling 5..79 CDD:238492
Atrophin-1 <81..254 CDD:331285 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 82..142
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 176..226
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 239..258 2/5 (40%)
LIM1_Enigma 282..333 CDD:188836 5/54 (9%)
LIM2_Enigma 341..392 CDD:188840 11/52 (21%)
LIM3_Enigma 400..454 CDD:188842 15/52 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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