DRSC/TRiP Functional Genomics Resources

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Protein Alignment Bx and LHX4

DIOPT Version :9

Sequence 1:NP_001259687.1 Gene:Bx / 32846 FlyBaseID:FBgn0265598 Length:424 Species:Drosophila melanogaster
Sequence 2:NP_203129.1 Gene:LHX4 / 89884 HGNCID:21734 Length:390 Species:Homo sapiens


Alignment Length:357 Identity:87/357 - (24%)
Similarity:129/357 - (36%) Gaps:131/357 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    92 CAGCGKHIQDRYLLRALDMLWHEDCLKCGCCDCRLGEVGSTLYTKGNLMLCKRDYLRLFGNTGYC 156
            ||||.:||.|:::|:.||..||..||||..|..:|.:   ..:::...:.||.|:.:.||..  |
Human    30 CAGCNQHILDKFILKVLDRHWHSSCLKCADCQMQLAD---RCFSRAGSVYCKEDFFKRFGTK--C 89

  Fly   157 AACSKVIPAFEMVMRARTNVYHLECFACQQCNHRFCVGDRFYLCEN-KILCEYDYE--------- 211
            .||.:.||..::|.:|:..||||.||||..||.:...||.|||.|: :::|:.|||         
Human    90 TACQQGIPPTQVVRKAQDFVYHLHCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSE 154

  Fly   212 ---------------ERLVFASMANHPMLKRHV-----SSLG----------------------- 233
                           |.|..| ..|.|...|||     |..|                       
Human   155 AGAKRPRTTITAKQLETLKNA-YKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKD 218

  Fly   234 ----------------QGSP-------------------------TGAAGAQNTAGGLLGGGPGG 257
                            :||.                         ....|..|...|.:|...||
Human   219 AGRHRWGQFYKSVKRSRGSSKQEKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGDVTGG 283

  Fly   258 GNVNGVGMVNGPRTPGDHNNNNNG-----PQTPTGGGSPFAAAAAAAAAAAHMKNQL-------- 309
            ..:||...::|  |...:.:..:|     ||:|        ::.::..:.|.:.|.|        
Human   284 QLMNGSFSMDG--TGQSYQDLRDGSPYGIPQSP--------SSISSLPSHAPLLNGLDYTVDSNL 338

  Fly   310 --------GASSXNKALGMGAAGAVVPGSGVG 333
                    |.|...:|:..|....:..||.||
Human   339 GIIAHAGQGVSQTLRAMAGGPTSDISTGSSVG 370

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BxNP_001259687.1 LIM1_LMO1_LMO3 92..146 CDD:188774 20/53 (38%)
LIM2_dLMO 156..210 CDD:188776 24/54 (44%)
LHX4NP_203129.1 LIM1_Lhx4 30..81 CDD:188852 20/53 (38%)
LIM2_Lhx3_Lhx4 89..144 CDD:188762 24/54 (44%)
Homeobox 160..213 CDD:306543 10/53 (19%)
Interaction with DNA. /evidence=ECO:0000305|PubMed:28473536 161..181 4/20 (20%)
Interaction with 5-mCpG DNA. /evidence=ECO:0000305|PubMed:28473536 199..211 0/11 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 230..253 2/22 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 356..390 5/15 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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