Protein Alignment Bx and LHX4

DIOPT Version :9

• Sequence 1: NP_001259687.1
• Gene: Bx / 32846
• FlyBaseID: FBgn0265598
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: NP_203129.1
• Gene: LHX4 / 89884
• HGNCID: 21734
• Length: 390
• Species: Homo sapiens
• Alignment Length: 357
• Identity: 87/357 - (24%)
• Similarity: 129/357 - (36%)
• Gaps: 131/357 - (36%)

  Fly    92 CAGCGKHIQDRYLLRALDMLWHEDCLKCGCCDCRLGEVGSTLYTKGNLMLCKRDYLRLFGNTGYC 156
            ||||.:||.|:::|:.||..||..||||..|..:|.:   ..:::...:.||.|:.:.||..  |
Human    30 CAGCNQHILDKFILKVLDRHWHSSCLKCADCQMQLAD---RCFSRAGSVYCKEDFFKRFGTK--C 89

  Fly   157 AACSKVIPAFEMVMRARTNVYHLECFACQQCNHRFCVGDRFYLCEN-KILCEYDYE--------- 211
            .||.:.||..::|.:|:..||||.||||..||.:...||.|||.|: :::|:.|||
Human    90 TACQQGIPPTQVVRKAQDFVYHLHCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSE 154

  Fly   212 ---------------ERLVFASMANHPMLKRHV-----SSLG----------------------- 233
                           |.|..| ..|.|...|||     |..|
Human   155 AGAKRPRTTITAKQLETLKNA-YKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKD 218

  Fly   234 ----------------QGSP-------------------------TGAAGAQNTAGGLLGGGPGG 257
                            :||.                         ....|..|...|.:|...||
Human   219 AGRHRWGQFYKSVKRSRGSSKQEKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGDVTGG 283

  Fly   258 GNVNGVGMVNGPRTPGDHNNNNNG-----PQTPTGGGSPFAAAAAAAAAAAHMKNQL-------- 309
            ..:||...::|  |...:.:..:|     ||:|        ::.::..:.|.:.|.|
Human   284 QLMNGSFSMDG--TGQSYQDLRDGSPYGIPQSP--------SSISSLPSHAPLLNGLDYTVDSNL 338

  Fly   310 --------GASSXNKALGMGAAGAVVPGSGVG 333
                    |.|...:|:..|....:..||.||
Human   339 GIIAHAGQGVSQTLRAMAGGPTSDISTGSSVG 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bx	NP_001259687.1	LIM1_LMO1_LMO3	92..146	CDD:188774	20/53 (38%)
		LIM2_dLMO	156..210	CDD:188776	24/54 (44%)
LHX4	NP_203129.1	LIM1_Lhx4	30..81	CDD:188852	20/53 (38%)
		LIM2_Lhx3_Lhx4	89..144	CDD:188762	24/54 (44%)
		Homeobox	160..213	CDD:306543	10/53 (19%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:28473536	161..181		4/20 (20%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000305|PubMed:28473536	199..211		0/11 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	230..253		2/22 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	356..390		5/15 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910