DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Bx and lhx2b

DIOPT Version :9

Sequence 1:	NP_001259687.1	Gene:	Bx / 32846	FlyBaseID:	FBgn0265598	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001035099.3	Gene:	lhx2b / 791744	ZFINID:	ZDB-GENE-051220-1	Length:	427	Species:	Danio rerio

Alignment Length:	276	Identity:	91/276 - (32%)
Similarity:	115/276 - (41%)	Gaps:	57/276 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 NGNVVNVVNSG------GAGGG----------NNGNGNVQSIAAAANNNNNNNNNGS------QL 91
            :||....|:|.      |..||          ..|..:..:|::|.:......|..|      .|
Zfish    19 DGNTCYSVSSAATMLFHGLPGGEMHGVMEEMERRGKSDSATISSAIDMGETETNMPSISGDRVAL 83

  Fly    92 CAGCGKHIQDRYLLRALDMLWHEDCLKCGCCDCRLG-EVGSTLYTKGNLMLCKRDYLRLFGNTGY 155
            |||||..|.|||.|.|:|..||..|||  ||:|:|. |...|.::|...:.||.||.|.| :...
Zfish    84 CAGCGGKISDRYYLLAVDKQWHMRCLK--CCECKLNLESELTCFSKDGSIYCKEDYYRRF-SVQR 145

  Fly   156 CAACSKVIPAFEMVMRARTNVYHLECFACQQCNHRFCVGDRFYLCENKILCEYDYEERLV--FAS 218
            ||.|...|.|.|||||||..||||.||.|..||.....||.|.:.::.:.|...:|..:.  |.:
Zfish   146 CARCHLGISASEMVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMKDSLVYCRLHFETLIQGDFPT 210

  Fly   219 MANHPMLKRHVSSLGQGSPTGAAGAQNTAGGLLGGGP-GGGNVNGVGMVNGPRTPGDHNNNNNGP 282
            ..||..:                 |.|.  ||...|| |....|||..|...|   .....:.||
Zfish   211 HFNHTDV-----------------APNK--GLSSTGPLGLSYYNGVNTVQKGR---PRKRKSPGP 253

  Fly   283 QTPTGGGSPFAAAAAA 298
                  |:..||..||
Zfish   254 ------GADLAAYNAA 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bx	NP_001259687.1	LIM1_LMO1_LMO3	92..146	CDD:188774	26/54 (48%)
Bx	NP_001259687.1	LIM2_dLMO	156..210	CDD:188776	25/53 (47%)
lhx2b	NP_001035099.3	LIM1_Lhx2	74..137	CDD:188853	28/64 (44%)
		LIM2_Lhx2_Lhx9	142..200	CDD:188763	25/57 (44%)
		COG5576	<267..389	CDD:227863
		Homeobox	290..342	CDD:278475
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910