DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bx and TGFB1I1

DIOPT Version :9

Sequence 1:	NP_001259687.1	Gene:	Bx / 32846	FlyBaseID:	FBgn0265598	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001035919.1	Gene:	TGFB1I1 / 7041	HGNCID:	11767	Length:	461	Species:	Homo sapiens

Alignment Length:	286	Identity:	59/286 - (20%)
Similarity:	94/286 - (32%)	Gaps:	103/286 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 TEPGLVGLSSNQQQQQQQQSQQSNAGMNSGGQNNGPNPNGNGNVVNVVNSGGAGGGNNGNGNVQS 73
            |:|.:|. |:|:                  |..:.|.|.|.|::..::            |.:||
Human   180 TQPPVVS-STNE------------------GSPSPPEPTGKGSLDTML------------GLLQS 213

  Fly    74 IAAAANNNNNNNNNGSQLCAGCGKHIQDRYLLRALDMLWHEDCLKCGCCDCRLGEVGSTLYTKGN 138
            ..    :..........||..|.|.|..: ::.||...||.:...||.|...||  ||:.:.|..
Human   214 DL----SRRGVPTQAKGLCGSCNKPIAGQ-VVTALGRAWHPEHFVCGGCSTALG--GSSFFEKDG 271

  Fly   139 LML-----------------------------------------------------------CKR 144
            ...                                                           |:|
Human   272 APFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRR 336

  Fly   145 DYLRLFGNTGYCAACSKVIPAFEMVMRARTNVYHLECFACQQCNHRFCVGDRFYLCENKILCEYD 209
            |:|:||...  |..|..  |..:..:.|.:.::|.:||.|::|...|. |..|:..|.:.|||..
Human   337 DFLQLFAPR--CQGCQG--PILDNYISALSALWHPDCFVCRECFAPFS-GGSFFEHEGRPLCENH 396

  Fly   210 YEERL-VFASMANHPMLKRHVSSLGQ 234
            :..|. ...:....|:..|.||:||:
Human   397 FHARRGSLCATCGLPVTGRCVSALGR 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bx	NP_001259687.1	LIM1_LMO1_LMO3	92..146	CDD:188774	18/112 (16%)
Bx	NP_001259687.1	LIM2_dLMO	156..210	CDD:188776	16/53 (30%)
TGFB1I1	NP_001035919.1	Interaction with PTK2B/PYK2	1..240		18/95 (19%)
		Transcription activation. /evidence=ECO:0000250	1..200		8/38 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..87
		LD motif 1	3..15
		Interaction with PTK2/FAK1. /evidence=ECO:0000250	83..136
		Paxillin	<86..>106	CDD:308898
		LD motif 2	92..104
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..152
		LD motif 3	157..168
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	172..205		10/43 (23%)
		LD motif 4	203..215		3/23 (13%)
		LIM1_Paxillin_like	228..280	CDD:259830	16/54 (30%)
		LIM2_Paxillin_like	287..338	CDD:188723	2/50 (4%)
		LIM3_Paxillin	346..398	CDD:188793	16/54 (30%)
		LIM4_Leupaxin	405..456	CDD:188796	6/18 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1593918at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920