DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bx and PXN

DIOPT Version :9

Sequence 1:	NP_001259687.1	Gene:	Bx / 32846	FlyBaseID:	FBgn0265598	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	XP_016875215.1	Gene:	PXN / 5829	HGNCID:	9718	Length:	1135	Species:	Homo sapiens

Alignment Length:	151	Identity:	42/151 - (27%)
Similarity:	67/151 - (44%)	Gaps:	9/151 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 NNNGSQLCAGCGKHIQDRYLLRALDMLWHEDCLKCGCCDCRLGEVGSTLYTKGNLMLCKRDYLRL 149
            :|..|..|..|...|.|: ::.|||..||.:...|..|....|..|  .:.|.....|::||..:
Human   954 HNLFSPRCYYCNGPILDK-VVTALDRTWHPEHFFCAQCGAFFGPEG--FHEKDGKAYCRKDYFDM 1015

  Fly   150 FGNTGYCAACSKVIPAFEMVMRARTNVYHLECFACQQCNHRFCVGDRFYLCENKILCEYDYEERL 214
            |...  |..|::.|  .|..:.|...::|.|||.|::|...| |...|:..:.:..||..|.||.
Human  1016 FAPK--CGGCARAI--LENYISALNTLWHPECFVCRECFTPF-VNGSFFEHDGQPYCEVHYHERR 1075

  Fly   215 -VFASMANHPMLKRHVSSLGQ 234
             ...|....|:..|.::::.:
Human  1076 GSLCSGCQKPITGRCITAMAK 1096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bx	NP_001259687.1	LIM1_LMO1_LMO3	92..146	CDD:188774	15/53 (28%)
Bx	NP_001259687.1	LIM2_dLMO	156..210	CDD:188776	16/53 (30%)
PXN	XP_016875215.1	Paxillin	60..259	CDD:281527
		LIM1_Paxillin_like	902..954	CDD:259830	42/151 (28%)
		LIM2_Paxillin	961..1012	CDD:188791	15/53 (28%)
		LIM3_Paxillin_like	1020..1072	CDD:188724	16/54 (30%)
		LIM4_Paxillin	1079..1130	CDD:188795	3/18 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1593918at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920