DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Bx and LIMS2

DIOPT Version :9

Sequence 1:	NP_001259687.1	Gene:	Bx / 32846	FlyBaseID:	FBgn0265598	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_060450.2	Gene:	LIMS2 / 55679	HGNCID:	16084	Length:	365	Species:	Homo sapiens

Alignment Length:	148	Identity:	41/148 - (27%)
Similarity:	68/148 - (45%)	Gaps:	17/148 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 GSQLCAGCGKHIQDRYLLRALDMLWHEDCLKCGCCDCRLGEVGSTLYTKGNLMLCKRDYLRLFGN 152
            |..:|..|.:.|:.| ::.||...||.:...|..|:...  :|...|.|..|..|:..|.:|||:
Human   218 GVPICGACRRPIEGR-VVNALGKQWHVEHFVCAKCEKPF--LGHRHYEKKGLAYCETHYNQLFGD 279

  Fly   153 TGYCAACSKVIPAFEMVMRARTNVYHLECFACQQCNHRFCVGDRFYLCENKILCEYDYEERLVFA 217
            .  |..||.||..  .|:.|....:.:.||:|..||.:..:.::|...:.|.:|:..||:
Human   280 V--CYNCSHVIEG--DVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK----- 335

  Fly   218 SMANHPM-LKRHVSSLGQ 234
                .|: ||:.:..|.:
Human   336 ----FPLELKKRLKKLSE 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bx	NP_001259687.1	LIM1_LMO1_LMO3	92..146	CDD:188774	15/53 (28%)
Bx	NP_001259687.1	LIM2_dLMO	156..210	CDD:188776	15/53 (28%)
LIMS2	NP_060450.2	LIM1_PINCH	39..97	CDD:188717
		LIM2_PINCH	100..151	CDD:188718
		LIM3_PINCH	164..214	CDD:188719
		LIM4_PINCH	220..273	CDD:188720	15/55 (27%)
		LIM5_PINCH	281..334	CDD:188721	15/54 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1593918at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010