DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Bx and FBLIM1

DIOPT Version :9

Sequence 1:	NP_001259687.1	Gene:	Bx / 32846	FlyBaseID:	FBgn0265598	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001019386.1	Gene:	FBLIM1 / 54751	HGNCID:	24686	Length:	374	Species:	Homo sapiens

Alignment Length:	157	Identity:	41/157 - (26%)
Similarity:	63/157 - (40%)	Gaps:	31/157 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 SQLCAGCGKHIQDRYL-LRALDMLWHEDCLKCGCCDCRLGEVGSTLYTKGNLMLCKRDYLRLFGN 152
            :.:||.|.|.:..|.| :.|:...:|..|..|..|..:|  .|.:.|.|....||:..|......
Human   180 TDICAFCHKTVSPRELAVEAMKRQYHAQCFTCRTCRRQL--AGQSFYQKDGRPLCEPCYQDTLER 242

  Fly   153 TGYCAACSKVIPAFEMVMRARTNVYHLECFACQQCNHRFCVGDRFYL--CENKILC---EYDYEE 212
               |..|.:|:.  :.::||....:|..||.|..|..  |:||..:.  .:|::.|   .|.||:
Human   243 ---CGKCGEVVR--DHIIRALGQAFHPSCFTCVTCAR--CIGDESFALGSQNEVYCLDDFYRYEK 300

  Fly   213 RLVFASMANHPMLKRHVSSLGQGSPTG 239
            .|                ..|.|:.||
Human   301 GL----------------CTGWGAGTG 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bx	NP_001259687.1	LIM1_LMO1_LMO3	92..146	CDD:188774	17/54 (31%)
Bx	NP_001259687.1	LIM2_dLMO	156..210	CDD:188776	16/58 (28%)
FBLIM1	NP_001019386.1	Filamin-binding	1..70
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..119
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	135..176
		LIM	183..236	CDD:259829	17/54 (31%)
		LIM2_FBLP-1	243..295	CDD:188758	15/55 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910