DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bx and LIMA1

DIOPT Version :9

Sequence 1:	NP_001259687.1	Gene:	Bx / 32846	FlyBaseID:	FBgn0265598	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001107018.1	Gene:	LIMA1 / 51474	HGNCID:	24636	Length:	760	Species:	Homo sapiens

Alignment Length:	189	Identity:	37/189 - (19%)
Similarity:	66/189 - (34%)	Gaps:	50/189 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 CAACSKVIPAFEMVMRARTNVYHLECFACQQCNHRFCVGDRFYLCENKILCEYDYEERLVFASMA 220
            |..|.|.:...|.:: |...|:|:.||.|..||::..:| .:.....:|.|:..:.:  :|.|..
Human   391 CVECQKTVYPMERLL-ANQQVFHISCFRCSYCNNKLSLG-TYASLHGRIYCKPHFNQ--LFKSKG 451

  Fly   221 N------HPMLKRHVSSLGQGS-----PTGAAGAQNTAGGLLGGGPGGGNVNGVGMVNGPRTPGD 274
            |      |...|...:|..:..     |...|.|:.|                      |.:||.
Human   452 NYDEGFGHRPHKDLWASKNENEEILERPAQLANARET----------------------PHSPGV 494

  Fly   275 HNNNNNGPQTPTGGGSPFAAAAAAAAAAAHMKNQLGASSXNKALG------MGAAGAVV 327
            .:       .|.......||:..|.|::...|....|.: ...:.      :|::|:.:
Human   495 ED-------APIAKVGVLAASMEAKASSQQEKEDKPAETKKLRIAWPPPTELGSSGSAL 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bx	NP_001259687.1	LIM1_LMO1_LMO3	92..146	CDD:188774
Bx	NP_001259687.1	LIM2_dLMO	156..210	CDD:188776	15/53 (28%)
LIMA1	NP_001107018.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	78..131
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..182
		Required for interaction with NPC1L1. /evidence=ECO:0000250\|UniProtKB:Q9ERG0	164..166
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..264
		LIM_Eplin_alpha_beta	391..443	CDD:188869	15/53 (28%)
		Required for interaction with MYO5B. /evidence=ECO:0000250\|UniProtKB:Q9ERG0	494..514		4/26 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..710		6/37 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910