DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bx and LIMK1

DIOPT Version :9

Sequence 1:	NP_001259687.1	Gene:	Bx / 32846	FlyBaseID:	FBgn0265598	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_002305.1	Gene:	LIMK1 / 3984	HGNCID:	6613	Length:	647	Species:	Homo sapiens

Alignment Length:	305	Identity:	82/305 - (26%)
Similarity:	120/305 - (39%)	Gaps:	72/305 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 GSQL--CAGCGKHIQDRYLLRALDMLWHEDCLKCGCCDCRLGEVGSTLYTKGNLMLCKRDYLRLF 150
            ||:|  ||.||:.|.|...|:||:..||.||.:  ||||. ..:....|.|...:.||:||...:
Human    19 GSELPVCASCGQRIYDGQYLQALNADWHADCFR--CCDCS-ASLSHQYYEKDGQLFCKKDYWARY 80

  Fly   151 GNTGYCAACSKVIPAFEMVMRARTNVYHLECFACQQCNHRFCVGDRFYLCE-NKILCEYDYE--- 211
            |.:  |..||:.|.. .:||.|....||.|||.|..|......||.:.|.| :|:.|.:.|.
Human    81 GES--CHGCSEQITK-GLVMVAGELKYHPECFICLTCGTFIGDGDTYTLVEHSKLYCGHCYYQTV 142

  Fly   212 -----ERLVFASMANH-----PMLKRHVSSLGQ----------GSPTGAAGAQNTAGGLLGGGPG 256
                 |:::..|..:|     .::....||.|:          ..|.|.....:....:.|..||
Human   143 VTPVIEQILPDSPGSHLPHTVTLVSIPASSHGKRGLSVSIDPPHGPPGCGTEHSHTVRVQGVDPG 207

  Fly   257 ------------GG---NVNGVGMVNGP--------------------RTPGDHNNNNNGPQT-P 285
                        |.   .:||..:.|.|                    ..|.|...:..||:| |
Human   208 CMSPDVKNSIHVGDRILEINGTPIRNVPLDEIDLLIQETSRLLQLTLEHDPHDTLGHGLGPETSP 272

  Fly   286 TGGGSPFAAAAAAAAAAAHMKNQLGASSXNKALGMGAAGAVVPGS 330
            .  .||....:..|.::|..|..|.:.|.:::.|.|:.|:  |.|
Human   273 L--SSPAYTPSGEAGSSARQKPVLRSCSIDRSPGAGSLGS--PAS 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bx	NP_001259687.1	LIM1_LMO1_LMO3	92..146	CDD:188774	21/53 (40%)
Bx	NP_001259687.1	LIM2_dLMO	156..210	CDD:188776	20/54 (37%)
LIMK1	NP_002305.1	LIM1_LIMK1	5..77	CDD:188846	25/60 (42%)
		LIM	84..138	CDD:295319	20/54 (37%)
		PDZ	165..255	CDD:278991	13/89 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..319		17/58 (29%)
		STKc_LIMK1	345..611	CDD:271123
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910