DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bx and ISL1

DIOPT Version :9

Sequence 1:	NP_001259687.1	Gene:	Bx / 32846	FlyBaseID:	FBgn0265598	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_002193.2	Gene:	ISL1 / 3670	HGNCID:	6132	Length:	349	Species:	Homo sapiens

Alignment Length:	148	Identity:	60/148 - (40%)
Similarity:	81/148 - (54%)	Gaps:	18/148 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 LCAGCGKHIQDRYLLR-ALDMLWHEDCLKCGCCDCRLGEVGSTLYTKGNLMLCKRDYLRLFGNTG 154
            ||.|||..|.|:|:|| :.|:.||..||||..|:..|.| ..|.:.:.....|||||:||:|..
Human    16 LCVGCGNQIHDQYILRVSPDLEWHAACLKCAECNQYLDE-SCTCFVRDGKTYCKRDYIRLYGIK- 78

  Fly   155 YCAACSKVIPAFEMVMRARTNVYHLECFACQQCNHRFCVGDRFYLCENKILCEYDYEERLVFASM 219
             ||.||......:.|||||:.|||:|||.|..|:.:...||.|.|.|:.:.|.
Human    79 -CAKCSIGFSKNDFVMRARSKVYHIECFRCVACSRQLIPGDEFALREDGLFCR------------ 130

  Fly   220 ANHPMLKRHVSSLGQGSP 237
            |:|.:::|  :|||.|.|
Human   131 ADHDVVER--ASLGAGDP 146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bx	NP_001259687.1	LIM1_LMO1_LMO3	92..146	CDD:188774	23/54 (43%)
Bx	NP_001259687.1	LIM2_dLMO	156..210	CDD:188776	23/53 (43%)
ISL1	NP_002193.2	LIM1_Isl	17..71	CDD:188752	23/54 (43%)
		LIM domain	20..73		23/53 (43%)
		LIM2_Isl	79..133	CDD:188760	24/65 (37%)
		LIM domain	82..136		23/65 (35%)
		HOX	181..237	CDD:197696
		Homeodomain	184..243
		LIM-binding domain (LID). /evidence=ECO:0000250	262..291
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	312..349
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910