DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bx and lhx5

DIOPT Version :9

Sequence 1:	NP_001259687.1	Gene:	Bx / 32846	FlyBaseID:	FBgn0265598	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_571293.1	Gene:	lhx5 / 30465	ZFINID:	ZDB-GENE-980526-484	Length:	399	Species:	Danio rerio

Alignment Length:	383	Identity:	94/383 - (24%)
Similarity:	132/383 - (34%)	Gaps:	124/383 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 CAGCGKHIQDRYLLRALDMLWHEDCLKCGCCDCRLGEVGSTLYTKGNLMLCKRDYLRLFGNTGYC 156
            ||||.:.|.||:||..||..||..|::|..|:|.|.|   ..:::...:.||.|:.|.||..  |
Zfish     5 CAGCERPILDRFLLNVLDRAWHAKCVQCCECNCNLTE---KCFSRDGKLYCKIDFFRRFGTK--C 64

  Fly   157 AACSKVIPAFEMVMRARTNVYHLECFACQQCNHRFCVGDRFYLC-ENKILCEYDYEERLVFASMA 220
            |.|.:.|...::|.|||:.|:||.||.|..||.:...|:..|:. |||.:|:.||     .::.|
Zfish    65 AGCLQGISPSDLVRRARSKVFHLNCFTCMVCNKQLSTGEELYVIDENKFVCKEDY-----LSASA 124

  Fly   221 NHPMLKRHVSSLGQGSPTGAAGAQNTAGGLLGGGPGGGNVNGVGMVNGPRTPGDHNNNNN----- 280
            ...:....|||.             |...|....|.....:.....|...:..|.|||.|
Zfish   125 IKEVNLNSVSSC-------------TDRSLSPDLPDQIQDDTKETDNSTSSDKDTNNNENEEQNS 176

  Fly   281 -----GPQTPTGG---GSPFAAAAAAAAAAAHMKNQLGASSXNKALGMGAAGAVVPGSGVGAGVG 337
                 ||:|....   .:..||..|......|::.||...:                       |
Zfish   177 CTKRRGPRTTIKAKQLETLKAAFVATPKPTRHIREQLAQET-----------------------G 218

  Fly   338 VGVGAASQQFYSGFGLQHQHQHQQHHQQQQQQQQLMGLG---------------LG--------M 379
            :.:......|            |....::::.:||..||               ||        |
Zfish   219 LNMRVIQVWF------------QNRRSKERRMKQLSALGARRHAFFRGPRRMRPLGGRLEDPDIM 271

  Fly   380 GGGG-GVGGGGAGSAGGP----------------------------GGGAGGGGGVGS 408
            |.|| ...|...|...||                            |.||..||.|.:
Zfish   272 GPGGYSYYGEYQGDYYGPVVNYDFFPHGPPSSQAHSPAESPYLLSSGSGALEGGPVSA 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bx	NP_001259687.1	LIM1_LMO1_LMO3	92..146	CDD:188774	21/53 (40%)
Bx	NP_001259687.1	LIM2_dLMO	156..210	CDD:188776	22/54 (41%)
lhx5	NP_571293.1	LIM1_Lhx1_Lhx5	5..56	CDD:188753	21/53 (40%)
		LIM2_Lhx1_Lhx5	64..119	CDD:188761	22/54 (41%)
		COG5576	126..>242	CDD:227863	25/163 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..185		11/61 (18%)
		Homeobox	183..236	CDD:278475	11/87 (13%)
		GATA-N	298..>390	CDD:283099	6/32 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..399		6/29 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910