DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15042 and Rnf17

DIOPT Version :9

Sequence 1:	NP_573308.1	Gene:	CG15042 / 32844	FlyBaseID:	FBgn0030937	Length:	436	Species:	Drosophila melanogaster
Sequence 2:	NP_001028215.1	Gene:	Rnf17 / 30054	MGIID:	1353419	Length:	1640	Species:	Mus musculus

Alignment Length:	362	Identity:	75/362 - (20%)
Similarity:	130/362 - (35%)	Gaps:	124/362 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 YCAYMIDAAKYTNMSGMERIFALPDDLKKLPALTIKCRLVNV------------AQMHIFITQN- 200
            :|..::.:..|:.           :.||.:|.|...|.|.::            |::......|
Mouse   576 FCLLLMKSEPYSE-----------ELLKDIPHLAHLCSLKDIVPYNSTEGWEKEAKVEFLKMVNK 629

  Fly   201 --VRLRVLGSNGLELLVALIRNRTNIRKIPSAQLPPISGDEYGNMDANDREVAKSFARYR----- 258
              |.::|.|.....|:|.|.:..||  || |:.:|         :...|..|....||:|
Mouse   630 KAVLMKVFGEEDDVLIVDLQKPPTN--KI-SSDMP---------VSLRDALVFMELARFRSQSPR 682

  Fly   259 -------------PKRRERGSIVRVHVTRIVSHAEFYARFADGPTVPTWSKSVMKRGTGDFRVWD 310
                         |...|..:.|.|.|..|.|..:||.:..:.....:..|::.:...|:.....
Mouse   683 SHSEKNTTLCYHPPILPEEMTEVSVMVCHINSPTDFYLQLMENLDFLSLLKTIEEFYKGEDGENL 747

  Fly   311 IVLAPYQ----------GRYHRAKIVDIFRCR-YRVYFLDFGITEYTSKKNL-----TFCYELEK 359
            .:|.|.|          |.::|||::.:...| ..|.::|||.|...:.|::     .|....||
Mouse   748 EILCPLQNQACVAKFEDGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEFLEPPEK 812

  Fly   360 A-QHNLAF---------------RFEILGTRRQ-----CPIPYINILEGIKHLEHTVL------- 396
            | :..||:               :||   .:.|     |.:        ||.||:.||
Mouse   813 AIKCKLAYVEPSKKSQWSKKAKEKFE---EKTQDKFVTCSV--------IKILENNVLLVELFDS 866

  Fly   397 ----RSDINVRIHNILKDG------GYVIR--LMKHI 421
                :|.:::. ..::|:|      ||.::  ..||:
Mouse   867 RAPGKSAVSIN-DQLVKEGLASYEAGYTLKDNSKKHL 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15042	NP_573308.1	TUDOR	310..351	CDD:119391	14/51 (27%)
Rnf17	NP_001028215.1	iSH2_PI3K_IA_R	158..>242	CDD:304922
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..376
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	413..435
		TUDOR	444..>551	CDD:278965
		TUDOR	698..819	CDD:278965	28/120 (23%)
		TUDOR	755..801	CDD:119391	11/45 (24%)
		TUDOR	937..1053	CDD:278965
		TUDOR	990..1036	CDD:119391
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1170..1191
		TUDOR	1196..1312	CDD:278965
		TUDOR	1250..1295	CDD:119391
		TUDOR	1426..1567	CDD:278965
		TUDOR	1501..1548	CDD:119391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900