DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15042 and TDRD5

DIOPT Version :9

Sequence 1:	NP_573308.1	Gene:	CG15042 / 32844	FlyBaseID:	FBgn0030937	Length:	436	Species:	Drosophila melanogaster
Sequence 2:	NP_001186014.1	Gene:	TDRD5 / 163589	HGNCID:	20614	Length:	1035	Species:	Homo sapiens

Alignment Length:	481	Identity:	98/481 - (20%)
Similarity:	168/481 - (34%)	Gaps:	130/481 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 CLLQPIRAV--PKCVNSKEILSSLARNPRKSRLYPPHGGHMRSVVGTFYKITDQIGEIAIGTKLT 79
            |..||...:  ||.:.|.|..|.| .....|||  .|...:..:..||..:..|||.       .
Human   238 CFSQPTSNMEPPKQIMSMEKTSKL-NVVETSRL--NHTEKLNQLENTFKSVIAQIGP-------G 292

  Fly    80 GTVLLE-SLPVFYVTINGPG----SKLLKCLAMGQVQLQELEQLPDYGEIFAFYDKAENRISRI- 138
            ||:..| ...:.:|....|.    ||||     |:.::...|||......|....:....:|.|
Human   293 GTISSELKHKIKFVVSKFPEGLFISKLL-----GEYEVIFKEQLSPKKLGFLNVTELVGALSDIL 352

  Fly   139 ---------------AINAPVHPM--------GYCAYMIDAAKYTNMSGMERIFALPDDLKKLPA 180
                           |...|:.|:        ..|.........:..:..|.::..|...:|.|.
Human   353 HVEFRKGHQDLLVFDADKKPLPPVQSDKKIEAKACVSSPPRNSLSTAAVKETVWNCPSKKQKEPQ 417

  Fly   181 LTIKCRLVNVAQMHIFITQNVRLRVLGSNGLELLVALIRNRTNIRKIPS---AQLPPISGDEYGN 242
            ..| |:..|:      :.:.::|:| .:|..||.:|:..:......:|:   .:|||:
Human   418 QKI-CKKPNL------VVKPLQLQV-ETNKSELNLAMANHDIPPDAVPNKKLCRLPPL------- 467

  Fly   243 MDANDREVAKSFARYRPKRRERGSIVRVHVTRIVSHAEFYARF--ADGPTVPTWSKSVMKRGTGD 305
                                :..|::.|.|..|:|.::||.|.  .|...:.......|:|...:
Human   468 --------------------DTSSLIGVFVEYIISPSQFYIRIYSRDSSELLEDMMIEMRRCYSN 512

  Fly   306 FRVWDIVLAP--------------------YQGRYHRAKIVDIFRCRYRVYFLDFGITEYTSKKN 350
            ..|.|..:.|                    |:...||.    :.:....|::.|||......|.:
Human   513 QLVSDRYVMPECFIQPGHLCCVRISEDKWWYRVIIHRV----LEKQEVEVFYPDFGNIGIVQKSS 573

  Fly   351 LTF---CYELEKAQH---NLAF---------RFEILGTRRQCPI-PYINI----LEGIKHLEHTV 395
            |.|   ||....||.   :||:         ...||..::.|.: |.:.:    ::||.::....
Human   574 LRFLKCCYTKLPAQAIPCSLAWVRPVEEHWTSKAILQFQKLCGLKPLVGVVDEYVDGILNIFLCD 638

  Fly   396 LRSDINVRIHNILKDGGYVIRLMKHI 421
            ..|:.:|..|::|:..|:.|...::|
Human   639 TSSNEDVYFHHVLRTEGHAIVCRENI 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15042	NP_573308.1	TUDOR	310..351	CDD:119391	10/60 (17%)
TDRD5	NP_001186014.1	LOTUS_1_TDRD5	4..98	CDD:193599
		LOTUS_2_TDRD5	132..201	CDD:193589
		LOTUS_3_TDRD5	296..369	CDD:193590	14/77 (18%)
		TUDOR	471..594	CDD:278965	28/126 (22%)
		TUDOR	529..575	CDD:119391	8/49 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900