DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15042 and TDRD15

DIOPT Version :9

Sequence 1:	NP_573308.1	Gene:	CG15042 / 32844	FlyBaseID:	FBgn0030937	Length:	436	Species:	Drosophila melanogaster
Sequence 2:	NP_001293066.1	Gene:	TDRD15 / 100129278	HGNCID:	45037	Length:	1934	Species:	Homo sapiens

Alignment Length:	320	Identity:	69/320 - (21%)
Similarity:	115/320 - (35%)	Gaps:	98/320 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 KAENRISRIAINAPVHPMGYCAYMIDA--------AKYTNMS---GMERI------FALPDDLKK 177
            |..|......||.| .|:.|....||.        |::...|   .||.:      .:|.|.||.
Human  1172 KTGNNYRHNVINKP-SPVTYSERKIDQLMHPKNIHARFLKPSVCYKMEPVSKNKMKTSLNDGLKG 1235

  Fly   178 LPALTIKCRLV---NVAQMHIFITQNVRLRVL----GSNGLELLVALIRNRTNIRKIPSAQLPPI 235
            :..:.....::   .|.|..:.:.....:|.|    ..|..:|:      |..|:.:|..|:
Human  1236 IKIVPGAAHILENRRVGQKSVKVVSQSFIRALNQTTSQNPYDLI------RPQIKDLPQPQI--- 1291

  Fly   236 SGDEYGNMDANDREVAKSFARYRPKRRERGSIVRVHVTRIVSHAEFYARFADGPTV--------P 292
                |.|        ||               |:.:|:.|.:.|.|:.:.|:..:|        .
Human  1292 ----YLN--------AK---------------VKGYVSNISNPANFHIQLAENESVIIRLADALN 1329

  Fly   293 TWSKSVMKRGTGDFRVWDIVLAPYQG--RYHRAKIVDIFRCR-YRVYFLDFGITEYTSKKNLTFC 354
            ..::.:.:|.:....|.|:|:|.|.|  ..:||.|..|.... :.|.|:|:|.:...   |.:..
Human  1330 ATARRLRERKSVKPLVGDLVVAEYSGDNAIYRAVIKKILPGNSFEVEFIDYGNSAIV---NTSKI 1391

  Fly   355 YELEKAQHNLAFRFEILGTRRQCPIPYINI---LEGIKHLEHTVLRSDINV-----RIHN 406
            |||::         |.|      .:|.:.|   |.|:|..|...:..|..|     ::||
Human  1392 YELQR---------EFL------TVPQLGIHAFLSGVKWNEPDEIWDDKTVDYFTSKVHN 1436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15042	NP_573308.1	TUDOR	310..351	CDD:119391	13/43 (30%)
TDRD15	NP_001293066.1	TUDOR	535..580	CDD:119391
		TUDOR	759..867	CDD:278965
		TUDOR	806..848	CDD:119391
		TUDOR	961..1084	CDD:278965
		TUDOR	1017..1062	CDD:119391
		TUDOR	1291..1412	CDD:278965	35/168 (21%)
		TUDOR	1346..1393	CDD:119391	14/49 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1490..1510
		TUDOR	1524..1641	CDD:278965
		TUDOR	1578..1624	CDD:119391
		TUDOR	1740..1852	CDD:278965
		TUDOR	1784..>1820	CDD:119391
		TUDOR	237..356	CDD:278965
		TUDOR	293..339	CDD:119391
		TUDOR	479..600	CDD:278965
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22948
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.000