DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HisRS and GCN2

DIOPT Version :9

Sequence 1:NP_573305.2 Gene:HisRS / 32841 FlyBaseID:FBgn0027087 Length:564 Species:Drosophila melanogaster
Sequence 2:NP_010569.3 Gene:GCN2 / 851877 SGDID:S000002691 Length:1659 Species:Saccharomyces cerevisiae


Alignment Length:553 Identity:128/553 - (23%)
Similarity:225/553 - (40%) Gaps:145/553 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 QIKVQGDLVRQLKAAKESKEKTAPSGGGRVSSSGVPAQRQQQ---------QQPQKQQQAQVQQQ 66
            ::||:..::|.|.....:|.   |.....::|..:|.:.|.:         ..|....|.||::.
Yeast   950 KMKVEKKIIRLLIDHDPNKR---PGARTLLNSGWLPVKHQDEVIKEALKSLSNPSSPWQQQVRES 1011

  Fly    67 QHEQLHQIDEEVARLLALKATLGGDAAPTNQKFTLKTPKGTRDYGPQQMTLRQGVLDKIVQVFKR 131
            ...|.:.:..::         |..::.||:..|.              ..||..:.:::|::|::
Yeast  1012 LFNQSYSLTNDI---------LFDNSVPTSTPFA--------------NILRSQMTEEVVKIFRK 1053

  Fly   132 HGGEAIDTP--VFELKEVLTGKYGEDSKLIYDLKDQGGEILSMRYDLTVPLARYLAMNKISSIKR 194
            |||...:.|  :|....:    ||..:  :|::.|:||.:|.::||||.|:||||:.|.....|:
Yeast  1054 HGGIENNAPPRIFPKAPI----YGTQN--VYEVLDKGGTVLQLQYDLTYPMARYLSKNPSLISKQ 1112

  Fly   195 YHIAKVYRRDNPAMTKGRYREFYQCDFDI-------AGTYDPMLPDAECVKIVSEILDTLDI--- 249
            |.:..|||..:.:.:....|:|.:.||||       :|.|     |||.:||:.|||....:   
Yeast  1113 YRMQHVYRPPDHSRSSLEPRKFGEIDFDIISKSSSESGFY-----DAESLKIIDEILTVFPVFEK 1172

  Fly   250 -GDYVIKLNHRQLLDGMFQACGVP----------------ADSFRTICSAVD-KLDKSPWADVRK 296
             ..:.| |||..:|:.:|....:.                |.||:.:.:.:. :|:.|..|....
Yeast  1173 TNTFFI-LNHADILESVFNFTNIDKAQRPLVSRMLSQVGFARSFKEVKNELKAQLNISSTALNDL 1236

  Fly   297 EMVDEKGLD-EAAADRIGEYVRLSGGAELVEQLLANEKLKAVPNAVKGLEGMKQLLKYCSIFGLD 360
            |:.|.: || |||..|            |.:.::.:..||.:.:::..:..:...||        
Yeast  1237 ELFDFR-LDFEAAKKR------------LYKLMIDSPHLKKIEDSLSHISKVLSYLK-------- 1280

  Fly   361 KRVSFDLSLARG-----LDYYTGVIYEGVLKGESATVASPAKTSQQNGEQANEPATVGSVAGGGR 420
                 .|.:||.     |..|....|:|.:...:.         ..:|...|      .:|.|||
Yeast  1281 -----PLEVARNVVISPLSNYNSAFYKGGIMFHAV---------YDDGSSRN------MIAAGGR 1325

  Fly   421 YDNLVGMF-DPRGK----AVPCVGVSIGVERIFSVLE---ARAAASGLKLRT------------S 465
            ||.|:..| .|.||    ....||.::..|.||.:.:   ..|:.:.:|.|.            |
Yeast  1326 YDTLISFFARPSGKKSSNTRKAVGFNLAWETIFGIAQNYFKLASGNRIKKRNRFLKDTAVDWKPS 1390

  Fly   466 DVEVYVASAHKGLHEQ-RLKVLNLLWDAGVKAE 497
            ..:|.::|....|.:. .:.:||.||...:||:
Yeast  1391 RCDVLISSFSNSLLDTIGVTILNTLWKQNIKAD 1423

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HisRSNP_573305.2 S15_NS1_EPRS_RNA-bind 6..92 CDD:294248 15/89 (17%)
HisS 98..561 CDD:223202 111/457 (24%)
HisRS-like_core 114..452 CDD:238396 97/378 (26%)
HisRS_anticodon 467..557 CDD:238436 9/32 (28%)
GCN2NP_010569.3 RWD 18..128 CDD:214735
PK_eIF2AK_GCN2_rpt1 273..526 CDD:270914
STKc_EIF2AK4_GCN2_rpt2 593..979 CDD:270948 6/31 (19%)
HisS 1015..1485 CDD:223202 115/485 (24%)
HGTP_anticodon2 1387..1657 CDD:403832 10/37 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.