Protein Alignment HisRS and Hars2

DIOPT Version :10

• Sequence 1: NP_573305.2
• Gene: HisRS / 32841
• FlyBaseID: FBgn0027087
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_542367.1
• Gene: Hars2 / 70791
• MGIID: 1918041
• Length: 505
• Species: Mus musculus
• Alignment Length: 482
• Identity: 261/482 - (54%)
• Similarity: 348/482 - (72%)
• Gaps: 16/482 - (3%)

  Fly    85 KATLGGDAAPTNQK---FTLKTPKGTRDYGPQQMTLRQGVLDKIVQVFKRHGGEAIDTPVFELKE 146
            ||.|..:...::|:   |.:|.||||||..||||.:|:.:||||:..|||||.:.:|||.|||||
Mouse    37 KAVLTSEQLKSHQEKPNFVIKVPKGTRDLSPQQMVVREKILDKIISCFKRHGAKGLDTPAFELKE 101

  Fly   147 VLTGKYGEDSKLIYDLKDQGGEILSMRYDLTVPLARYLAMNKISSIKRYHIAKVYRRDNPAMTKG 211
            :||.||.::..|:|||||||||:||:|||||||.||||||||:..:|||.:.||:||::||:.:|
Mouse   102 MLTEKYEDNFGLMYDLKDQGGELLSLRYDLTVPFARYLAMNKLKKMKRYQVGKVWRRESPAIAQG 166

  Fly   212 RYREFYQCDFDIAGTYDPMLPDAECVKIVSEILDTLDIGDYVIKLNHRQLLDGMFQACGVPADSF 276
            |||||.||||||||.:|||:|||||::|:.|||..|.:||::||:|.|:::||:|..||||....
Mouse   167 RYREFCQCDFDIAGEFDPMIPDAECLRIMCEILSGLQLGDFLIKVNDRRVVDGIFAVCGVPESKL 231

  Fly   277 RTICSAVDKLDKSPWADVRKEMVDEKGLDEAAADRIGEYVRLSGGAELVEQLLANEKLKAVPNAV 341
            |||||::|||||..|..||.|||.:|||....|||||::|:..||..|||.|..:.:|.....|:
Mouse   232 RTICSSMDKLDKMSWEGVRHEMVAKKGLAPEVADRIGDFVQYHGGISLVEDLFKDPRLSQSQLAL 296

  Fly   342 KGLEGMKQLLKYCSIFGLDKRVSFDLSLARGLDYYTGVIYEGVLKGESATVASPAKTSQQNGEQA 406
            :||..:|.|.:|..:||:..::|.|||||||||||||||||.||      :.|||:..:
Mouse   297 QGLGDLKLLFEYLRLFGIADKISLDLSLARGLDYYTGVIYEAVL------LESPAQAGK------ 349

  Fly   407 NEPATVGSVAGGGRYDNLVGMFDPRGKAVPCVGVSIGVERIFSVLEARAAASGLKLRTSDVEVYV 471
             |..:|||||.||||||||..|||:|..|||||:||||||||.::|.:...||.|:||::.:|:|
Mouse   350 -ETLSVGSVAAGGRYDNLVAQFDPKGHHVPCVGLSIGVERIFYLVEQKMKMSGEKVRTTETQVFV 413

  Fly   472 ASAHKGLHEQRLKVLNLLWDAGVKAEHSYKLNPKLLVQLQHCEEHQIPLVVVLGDAELAQGLVKL 536
            |:..|...::|||::..|||||:|||..||.|||||.||.:||:..|||:|::|:.|..:|::||
Mouse   414 ATPQKNFLQERLKIIAELWDAGIKAEMLYKNNPKLLTQLHYCEKADIPLMVIIGEQERNEGVIKL 478

  Fly   537 REVTTREETNVKLEDLAAEIRRRQQAS 563
            |.|.:|||..:..|.|.|||::|...|
Mouse   479 RSVASREEVTINRESLVAEIQKRLSES 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisRS	NP_573305.2	S15_NS1_EPRS_RNA-bind	6..92	CDD:469733	3/6 (50%)
		PLN02972	<102..559	CDD:215525	254/456 (56%)
Hars2	NP_542367.1	PLN02972	<57..503	CDD:215525	255/458 (56%)