DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HisRS and hars

DIOPT Version :9

Sequence 1:	NP_573305.2	Gene:	HisRS / 32841	FlyBaseID:	FBgn0027087	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001289185.1	Gene:	hars / 447847	ZFINID:	ZDB-GENE-040912-152	Length:	520	Species:	Danio rerio

Alignment Length:	492	Identity:	312/492 - (63%)
Similarity:	376/492 - (76%)	Gaps:	11/492 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 LHQIDEEVARLLALKATLGGDAAPTNQKFTLKTPKGTRDYGPQQMTLRQGVLDKIVQVFKRHGGE 135
            :.||||||||||.|||.||||..  ...|.|||.||||||.|:||.:|:.|.:.|:..|||||.|
Zfish    35 ISQIDEEVARLLQLKAQLGGDEG--KHVFVLKTAKGTRDYNPKQMAIREKVFNIIINCFKRHGAE 97

  Fly   136 AIDTPVFELKEVLTGKYGEDSKLIYDLKDQGGEILSMRYDLTVPLARYLAMNKISSIKRYHIAKV 200
            .||:|||||||.|||||||||||||||||||||:||:|||||||.|||||||||::|||||||||
Zfish    98 TIDSPVFELKETLTGKYGEDSKLIYDLKDQGGELLSLRYDLTVPFARYLAMNKITNIKRYHIAKV 162

  Fly   201 YRRDNPAMTKGRYREFYQCDFDIAGTYDPMLPDAECVKIVSEILDTLDIGDYVIKLNHRQLLDGM 265
            |||||||||:|||||||||||||||.||.|:|||||:|:|.|||..||:||:.||:|.|::||||
Zfish   163 YRRDNPAMTRGRYREFYQCDFDIAGQYDAMIPDAECLKLVYEILSELDLGDFRIKVNDRRILDGM 227

  Fly   266 FQACGVPADSFRTICSAVDKLDKSPWADVRKEMVDEKGLDEAAADRIGEYVRLSGGAELVEQLLA 330
            |..||||.:.||||||.||||||..|.:|:||||:||||.|..||||.:||.:.||.:|.|:||.
Zfish   228 FAICGVPDEKFRTICSTVDKLDKLAWEEVKKEMVNEKGLSEEVADRIRDYVSMQGGKDLAERLLQ 292

  Fly   331 NEKLKAVPNAVKGLEGMKQLLKYCSIFGLDKRVSFDLSLARGLDYYTGVIYEGVLKGESATVASP 395
            :.||.....|..|:..||.|..|..:|.:..:|.||||||||||||||||||.:|     |.|:|
Zfish   293 DPKLSQSKQACAGITDMKLLFSYLELFQITDKVVFDLSLARGLDYYTGVIYEAIL-----TQANP 352

  Fly   396 AKTS---QQNGEQANEPATVGSVAGGGRYDNLVGMFDPRGKAVPCVGVSIGVERIFSVLEARAAA 457
            |..|   :|||.: :...:|||||||||||.|||||||:|:.|||||||||:||:||::|.:|..
Zfish   353 APASTPAEQNGAE-DAGVSVGSVAGGGRYDGLVGMFDPKGRKVPCVGVSIGIERVFSIMEQKAEL 416

  Fly   458 SGLKLRTSDVEVYVASAHKGLHEQRLKVLNLLWDAGVKAEHSYKLNPKLLVQLQHCEEHQIPLVV 522
            |..|:||::.:|.||||.|.|.|:|||:...||:||:|||..||.|||||.||||||:..||||.
Zfish   417 SSEKVRTTETQVLVASAQKNLLEERLKLTAELWNAGIKAEVLYKKNPKLLSQLQHCEDTGIPLVA 481

  Fly   523 VLGDAELAQGLVKLREVTTREETNVKLEDLAAEIRRR 559
            :||:.||..|:||||.|.:|||.:|...:|..|:::|
Zfish   482 ILGEQELKDGVVKLRNVASREEVDVPRAELVDEVKKR 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HisRS	NP_573305.2	S15_NS1_EPRS_RNA-bind	6..92	CDD:294248	16/20 (80%)
		HisS	98..561	CDD:223202	295/465 (63%)
		HisRS-like_core	114..452	CDD:238396	226/340 (66%)
		HisRS_anticodon	467..557	CDD:238436	51/89 (57%)
hars	NP_001289185.1	S15_NS1_EPRS_RNA-bind	<37..56	CDD:294248	16/18 (89%)
		HisS	63..518	CDD:223202	293/460 (64%)
		HisRS-like_core	76..411	CDD:238396	226/340 (66%)
		HisRS_anticodon	425..516	CDD:238436	51/90 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594170
Domainoid	1	1.000	401	1.000	Domainoid score	I697
eggNOG	1	0.900	-	-		E1_COG0124
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1592
Inparanoid	1	1.050	622	1.000	Inparanoid score	I850
OMA	1	1.010	-	-		QHG55859
OrthoDB	1	1.010	-	-		D1065556at2759
OrthoFinder	1	1.000	-	-		FOG0001634
OrthoInspector	1	1.000	-	-		oto41379
orthoMCL	1	0.900	-	-		OOG6_100351
Panther	1	1.100	-	-	LDO	PTHR11476
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1442
SonicParanoid	1	1.000	-	-		X1525
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800