DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HisRS and Hars1

DIOPT Version :9

Sequence 1:	NP_573305.2	Gene:	HisRS / 32841	FlyBaseID:	FBgn0027087	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001020585.1	Gene:	Hars1 / 307492	RGDID:	1310695	Length:	508	Species:	Rattus norvegicus

Alignment Length:	559	Identity:	329/559 - (58%)
Similarity:	398/559 - (71%)	Gaps:	58/559 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSDTREQILEQIKVQGDLVRQLKAAKESKEKTAPSGGGRVSSSGVPAQRQQQQQPQKQQQAQVQQ 65
            |:| |..:.|.:::||..||.||..|.|.|
  Rat     1 MAD-RAALEELVRLQGAHVRGLKEQKASAE----------------------------------- 29

  Fly    66 QQHEQLHQIDEEVARLLALKATLGGDAAPTNQKFTLKTPKGTRDYGPQQMTLRQGVLDKIVQVFK 130
                   ||:|||.:||.|||.||.|..  .|||.||||||||||.|:||.:|:.|.|.|::.||
  Rat    30 -------QIEEEVTKLLKLKAQLGHDEG--KQKFVLKTPKGTRDYSPRQMAVREKVFDVIIRCFK 85

  Fly   131 RHGGEAIDTPVFELKEVLTGKYGEDSKLIYDLKDQGGEILSMRYDLTVPLARYLAMNKISSIKRY 195
            |||.|.||||||||||.|||||||||||||||||||||:||:|||||||.||||||||:::||||
  Rat    86 RHGAEVIDTPVFELKETLTGKYGEDSKLIYDLKDQGGELLSLRYDLTVPFARYLAMNKLTNIKRY 150

  Fly   196 HIAKVYRRDNPAMTKGRYREFYQCDFDIAGTYDPMLPDAECVKIVSEILDTLDIGDYVIKLNHRQ 260
            ||||||||||||||:|||||||||||||||.:|||:|||||:||:.|||.:|.||::.:|:|.|:
  Rat   151 HIAKVYRRDNPAMTRGRYREFYQCDFDIAGQFDPMIPDAECLKIMCEILSSLQIGNFQVKVNDRR 215

  Fly   261 LLDGMFQACGVPADSFRTICSAVDKLDKSPWADVRKEMVDEKGLDEAAADRIGEYVRLSGGAELV 325
            :|||||..||||...||||||:||||||..|.:|:.|||.||||....|||||:||:..||..||
  Rat   216 ILDGMFAVCGVPDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLV 280

  Fly   326 EQLLANEKLKAVPNAVKGLEGMKQLLKYCSIFGLDKRVSFDLSLARGLDYYTGVIYEGVLKGESA 390
            ||||.:.||.....||:||..:|.|.:|.::||:|.::|||||||||||||||||||.||
  Rat   281 EQLLQDPKLSQNKQAVEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVL----- 340

  Fly   391 TVASPAKTSQQNGEQANEPATVGSVAGGGRYDNLVGMFDPRGKAVPCVGVSIGVERIFSVLEARA 455
                 .:...|.||   ||..|||:|.|||||.|||||||:|:.|||||:|||||||||::|.:.
  Rat   341 -----LQMPTQAGE---EPLGVGSIAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQKL 397

  Fly   456 AASGLKLRTSDVEVYVASAHKGLHEQRLKVLNLLWDAGVKAEHSYKLNPKLLVQLQHCEEHQIPL 520
            .||..|:||::.:|.||||.|.|.|:|||:::.|||||:|||..||.|||||.|||:|||..|||
  Rat   398 EASEEKVRTTETQVLVASAQKKLLEERLKLISELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPL 462

  Fly   521 VVVLGDAELAQGLVKLREVTTREETNVKLEDLAAEIRRR 559
            |.::|:.||..|::|||.||:|||.:|:.|||..|||||
  Rat   463 VAIIGEQELKDGVIKLRSVTSREEVDVRREDLVEEIRRR 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HisRS	NP_573305.2	S15_NS1_EPRS_RNA-bind	6..92	CDD:294248	22/85 (26%)
		HisS	98..561	CDD:223202	302/462 (65%)
		HisRS-like_core	114..452	CDD:238396	226/337 (67%)
		HisRS_anticodon	467..557	CDD:238436	53/89 (60%)
Hars1	NP_001020585.1	HisRS_RNA	5..49	CDD:238474	22/85 (26%)
		HisS	56..501	CDD:223202	298/457 (65%)
		HisRS-like_core	69..394	CDD:238396	226/337 (67%)
		HisRS_anticodon	408..499	CDD:238436	53/90 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352237
Domainoid	1	1.000	413	1.000	Domainoid score	I653
eggNOG	1	0.900	-	-		E1_COG0124
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1592
Inparanoid	1	1.050	631	1.000	Inparanoid score	I808
OMA	1	1.010	-	-		QHG55859
OrthoDB	1	1.010	-	-		D1065556at2759
OrthoFinder	1	1.000	-	-		FOG0001634
OrthoInspector	1	1.000	-	-		otm45564
orthoMCL	1	0.900	-	-		OOG6_100351
Panther	1	1.100	-	-	LDO	PTHR11476
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1525
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770