DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HisRS and Hars2

DIOPT Version :9

Sequence 1:	NP_573305.2	Gene:	HisRS / 32841	FlyBaseID:	FBgn0027087	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001014034.2	Gene:	Hars2 / 307491	RGDID:	1308426	Length:	507	Species:	Rattus norvegicus

Alignment Length:	482	Identity:	266/482 - (55%)
Similarity:	347/482 - (71%)	Gaps:	16/482 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 KATLGGD-AAPTNQK--FTLKTPKGTRDYGPQQMTLRQGVLDKIVQVFKRHGGEAIDTPVFELKE 146
            ||.|..: ..|..||  |.:|.||||||..||||.:|:.:||||:..|||||.:.:|||.|||||
  Rat    39 KAVLTSEQLKPHQQKPNFIIKVPKGTRDLSPQQMVVREKILDKIISCFKRHGAKGLDTPAFELKE 103

  Fly   147 VLTGKYGEDSKLIYDLKDQGGEILSMRYDLTVPLARYLAMNKISSIKRYHIAKVYRRDNPAMTKG 211
            :||.||.::..|:|||:|||||:||:|||||||.||||||||:..:|||.:.||:||::||:.:|
  Rat   104 MLTEKYEDNFGLMYDLEDQGGELLSLRYDLTVPFARYLAMNKLKRMKRYQVGKVWRRESPAIVQG 168

  Fly   212 RYREFYQCDFDIAGTYDPMLPDAECVKIVSEILDTLDIGDYVIKLNHRQLLDGMFQACGVPADSF 276
            |||||.||||||||.:|||:|||||::|:.|||..|.:||::||:|.|:::||||..||||...|
  Rat   169 RYREFCQCDFDIAGEFDPMIPDAECLRIMCEILSGLQLGDFLIKVNDRRVVDGMFAVCGVPESKF 233

  Fly   277 RTICSAVDKLDKSPWADVRKEMVDEKGLDEAAADRIGEYVRLSGGAELVEQLLANEKLKAVPNAV 341
            |||||::|||||..|.|||.|||..|||....|||||:||:..||..|||:|..:.:|.....|:
  Rat   234 RTICSSMDKLDKMSWEDVRLEMVAGKGLAPEVADRIGDYVQCHGGISLVEELFKDPRLSQSQLAL 298

  Fly   342 KGLEGMKQLLKYCSIFGLDKRVSFDLSLARGLDYYTGVIYEGVLKGESATVASPAKTSQQNGEQA 406
            :||..:|.|.:|..:||:..::|.|||||||||||||||||.||      :.|||:..:
  Rat   299 QGLGDLKLLFEYLRLFGIADKISLDLSLARGLDYYTGVIYEAVL------LESPAQAGK------ 351

  Fly   407 NEPATVGSVAGGGRYDNLVGMFDPRGKAVPCVGVSIGVERIFSVLEARAAASGLKLRTSDVEVYV 471
             |...|||||.|||||.||..|||:|.:|||||:||||||||.::|.:...|..|:||::.:|:|
  Rat   352 -ETLNVGSVAAGGRYDRLVAQFDPKGHSVPCVGLSIGVERIFYLVEQKMKISCEKVRTTETQVFV 415

  Fly   472 ASAHKGLHEQRLKVLNLLWDAGVKAEHSYKLNPKLLVQLQHCEEHQIPLVVVLGDAELAQGLVKL 536
            |:..|...::|||::..|||||:|||..||.|||||.||.:||:..|||:|::|:.|..:|:|||
  Rat   416 ATPQKNFLQERLKIIAQLWDAGIKAEMLYKNNPKLLTQLHYCEKEDIPLMVIIGEQEQNEGVVKL 480

  Fly   537 REVTTREETNVKLEDLAAEIRRRQQAS 563
            |.|.:|||..|..|.|.|||::|...|
  Rat   481 RSVASREEVTVNRESLVAEIQKRLSES 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HisRS	NP_573305.2	S15_NS1_EPRS_RNA-bind	6..92	CDD:294248	3/7 (43%)
		HisS	98..561	CDD:223202	260/464 (56%)
		HisRS-like_core	114..452	CDD:238396	196/337 (58%)
		HisRS_anticodon	467..557	CDD:238436	46/89 (52%)
Hars2	NP_001014034.2	HisS	58..505	CDD:223202	258/459 (56%)
		HisRS-like_core	71..396	CDD:238396	196/337 (58%)
		HisRS_anticodon	410..501	CDD:238436	46/90 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352238
Domainoid	1	1.000	413	1.000	Domainoid score	I653
eggNOG	1	0.900	-	-		E1_COG0124
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	631	1.000	Inparanoid score	I808
OMA	1	1.010	-	-		QHG55859
OrthoDB	1	1.010	-	-		D1065556at2759
OrthoFinder	1	1.000	-	-		FOG0001634
OrthoInspector	1	1.000	-	-		otm45564
orthoMCL	1	0.900	-	-		OOG6_100351
Panther	1	1.100	-	-	O	PTHR11476
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1525
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770