Protein Alignment HisRS and HARS1

DIOPT Version :10

• Sequence 1: NP_573305.2
• Gene: HisRS / 32841
• FlyBaseID: FBgn0027087
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_002100.2
• Gene: HARS1 / 3035
• HGNCID: 4816
• Length: 509
• Species: Homo sapiens
• Alignment Length: 555
• Identity: 327/555 - (58%)
• Similarity: 396/555 - (71%)
• Gaps: 57/555 - (10%)

  Fly     5 REQILEQIKVQGDLVRQLKAAKESKEKTAPSGGGRVSSSGVPAQRQQQQQPQKQQQAQVQQQQHE 69
            |..:.|.:|:||:.||.||..|.|.|
Human     4 RAALEELVKLQGERVRGLKQQKASAE--------------------------------------- 29

  Fly    70 QLHQIDEEVARLLALKATLGGDAAPTNQKFTLKTPKGTRDYGPQQMTLRQGVLDKIVQVFKRHGG 134
               .|:||||:||.|||.||.|  .:.|||.||||||||||.|:||.:|:.|.|.|::.|||||.
Human    30 ---LIEEEVAKLLKLKAQLGPD--ESKQKFVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGA 89

  Fly   135 EAIDTPVFELKEVLTGKYGEDSKLIYDLKDQGGEILSMRYDLTVPLARYLAMNKISSIKRYHIAK 199
            |.||||||||||.|.|||||||||||||||||||:||:|||||||.||||||||:::||||||||
Human    90 EVIDTPVFELKETLMGKYGEDSKLIYDLKDQGGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAK 154

  Fly   200 VYRRDNPAMTKGRYREFYQCDFDIAGTYDPMLPDAECVKIVSEILDTLDIGDYVIKLNHRQLLDG 264
            ||||||||||:|||||||||||||||.:|||:|||||:||:.|||.:|.|||:::|:|.|::|||
Human   155 VYRRDNPAMTRGRYREFYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDG 219

  Fly   265 MFQACGVPADSFRTICSAVDKLDKSPWADVRKEMVDEKGLDEAAADRIGEYVRLSGGAELVEQLL 329
            ||..|||....||||||:||||||..|.:|:.|||.||||....|||||:||:..||..||||||
Human   220 MFAICGVSDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLL 284

  Fly   330 ANEKLKAVPNAVKGLEGMKQLLKYCSIFGLDKRVSFDLSLARGLDYYTGVIYEGVLKGESATVAS 394
            .:.||.....|::||..:|.|.:|.::||:|.::|||||||||||||||||||.||
Human   285 QDPKLSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVL--------- 340

  Fly   395 PAKTSQQNGEQANEPATVGSVAGGGRYDNLVGMFDPRGKAVPCVGVSIGVERIFSVLEARAAASG 459
             .:|..|.||   ||..|||||.|||||.|||||||:|:.|||||:|||||||||::|.|..|..
Human   341 -LQTPAQAGE---EPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALE 401

  Fly   460 LKLRTSDVEVYVASAHKGLHEQRLKVLNLLWDAGVKAEHSYKLNPKLLVQLQHCEEHQIPLVVVL 524
            .|:||::.:|.||||.|.|.|:|||:::.|||||:|||..||.|||||.|||:|||..||||.::
Human   402 EKIRTTETQVLVASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAII 466

  Fly   525 GDAELAQGLVKLREVTTREETNVKLEDLAAEIRRR 559
            |:.||..|::|||.||:|||.:|:.|||..||:||
Human   467 GEQELKDGVIKLRSVTSREEVDVRREDLVEEIKRR 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisRS	NP_573305.2	S15_NS1_EPRS_RNA-bind	6..92	CDD:469733	23/85 (27%)
		PLN02972	<102..559	CDD:215525	296/456 (65%)
HARS1	NP_002100.2	HisRS_RNA	5..49	CDD:238474	24/87 (28%)
		PLN02972	<57..501	CDD:215525	296/456 (65%)