DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HisRS and EIF2AK1

DIOPT Version :9

Sequence 1:	NP_573305.2	Gene:	HisRS / 32841	FlyBaseID:	FBgn0027087	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_055228.2	Gene:	EIF2AK1 / 27102	HGNCID:	24921	Length:	630	Species:	Homo sapiens

Alignment Length:	444	Identity:	80/444 - (18%)
Similarity:	142/444 - (31%)	Gaps:	146/444 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 AIDTPVFELKEVLTGKYGEDSKLIYDLKDQGGEILSMRYDLTVPLARYLAMNKISSIKRY-HIAK 199
            |||.|.          .|.|.:  ||..|...||..::..|..|...:...|::..:... |::.
Human    26 AIDFPA----------EGPDPE--YDESDVPAEIQVLKEPLQQPTFPFAVANQLLLVSLLEHLSH 78

  Fly   200 VYRRDNPAMTKGRYREFYQCDFDIAGTYDPMLPDAECVKIVSEILDTLDIGDYVIKLNHRQLLDG 264
            |: ..||..::..::...|....:.     :|....|....|.           ::|:|.:.:..
Human    79 VH-EPNPLRSRQVFKLLCQTFIKMG-----LLSSFTCSDEFSS-----------LRLHHNRAITH 126

  Fly   265 MFQACGVPADSFRTICSAVDKLDKSPWAD---VRKEMVDEKGLDEAAADRIGEYVRLSGGAELVE 326
            :.:             ||.:::.:.|..|   ::|....|..|:...:..:.|:..|:
Human   127 LMR-------------SAKERVRQDPCEDISRIQKIRSREVALEAQTSRYLNEFEELA------- 171

  Fly   327 QLLANEKLKAVPNAVKGLEGMKQLLKYCSIFGLDKRVSF----DLSLARGLD------YYTGVIY 381
             :|.......|......|:|....:|...|.|..|.|..    ::.:..||.      |:|..|.
Human   172 -ILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIE 235

  Fly   382 E-------------------------------GVLKGESAT----VASPAKTSQQN-GEQANEPA 410
            .                               ||...||::    .|.|....::. ||...|..
Human   236 HVHVIQPRADRAAIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQ 300

  Fly   411 TVGSVAGGGRY-DNLVGMFDPRGKAVPCVGVSIGVERIFSVLEARAAASGLKLRTSDVEVYVASA 474
            ...||    :| .|||                        :.|:....|.|:|:.:.:....||:
Human   301 NNKSV----KYTTNLV------------------------IRESGELESTLELQENGLAGLSASS 337

  Fly   475 HKGLHEQRLKVL--NLLWDAGVKAEHSYKLNPKLL------------VQLQHCE 514
               :.||:|.:.  :.|.::....|.|.:.|...|            :|:|.||
Human   338 ---IVEQQLPLRRNSHLEESFTSTEESSEENVNFLGQTEAQYHLMLHIQMQLCE 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HisRS	NP_573305.2	S15_NS1_EPRS_RNA-bind	6..92	CDD:294248
		HisS	98..561	CDD:223202	80/444 (18%)
		HisRS-like_core	114..452	CDD:238396	62/366 (17%)
		HisRS_anticodon	467..557	CDD:238436	14/62 (23%)
EIF2AK1	NP_055228.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40		7/25 (28%)
		STKc_EIF2AK1_HRI	160..581	CDD:270951	49/268 (18%)
		S_TKc	167..583	CDD:214567	48/261 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	259..301		9/41 (22%)
		HRM 1	410..415
		HRM 2	552..557
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900