Protein Alignment HisRS and hrs1

DIOPT Version :9

• Sequence 1: NP_573305.2
• Gene: HisRS / 32841
• FlyBaseID: FBgn0027087
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_596441.2
• Gene: hrs1 / 2540472
• PomBaseID: SPBC2G2.12
• Length: 563
• Species: Schizosaccharomyces pombe
• Alignment Length: 577
• Identity: 276/577 - (47%)
• Similarity: 371/577 - (64%)
• Gaps: 63/577 - (10%)

  Fly     1 MSDTREQILEQIKVQGDLVRQLKAAKESKEKTAPSGGGRVSSSGVPAQRQQQQQPQKQQQAQVQQ 65
            |:|:...|.|:|..||:|||.||:...|||
pombe    26 MADSLVDINERITSQGNLVRSLKSQGASKE----------------------------------- 55

  Fly    66 QQHEQLHQIDEEVARLLALK-ATLGGDAAPTNQK---FTLKTPKGTRDYGPQQMTLRQGVLDKIV 126
                   .||:|||:||.|| ..|||......:|   |||||||||:|:..:.:.||:.:...:.
pombe    56 -------DIDKEVAKLLQLKNLKLGGSEVSGKKKDTSFTLKTPKGTKDWCDKDVVLREHIFSTVT 113

  Fly   127 QVFKRHGGEAIDTPVFELKEVLTGKYGEDSKLIYDLKDQGGEILSMRYDLTVPLARYLAMN-KIS 190
            ::||||||..:|||||||||:|:|||||||||||||||||||:.|:|||||||.||:|||| |::
pombe   114 EIFKRHGGVTLDTPVFELKEILSGKYGEDSKLIYDLKDQGGELCSLRYDLTVPFARWLAMNPKVT 178

  Fly   191 SIKRYHIAKVYRRDNPAMTKGRYREFYQCDFDIAGTYDPMLPDAECVKIVSEILDTLDIGDYVIK 255
            ||||:|||||||||.|||||||.||||||||||||.||||:||:|.:|::.|.||.|::|:|.||
pombe   179 SIKRFHIAKVYRRDQPAMTKGRMREFYQCDFDIAGNYDPMIPDSEALKVLVEALDALEVGNYTIK 243

  Fly   256 LNHRQLLDGMFQACGVPADSFRTICSAVDKLDKSPWADVRKEMVDEKGLDEAAADRIGEYVRLSG 320
            ||||::|||:|..||||.|..|||.||||||||.||.|||:|||.||||.|..||:|.|||.|.|
pombe   244 LNHRKILDGIFTVCGVPDDKIRTISSAVDKLDKLPWEDVRREMVVEKGLKEEVADKIKEYVLLKG 308

  Fly   321 GAELVEQLLANEKLKAVPNAVKGLEGMKQLLKYCSIFGLDKRVSFDLSLARGLDYYTGVIYEGVL 385
            ...|:::|.|:..|.:..:||.....|:.|..|...||:..|.|||:|||||||||||:|||.|.
pombe   309 DRSLLDKLEADSLLSSNSSAVAAFNDMRLLFDYLEAFGVLDRFSFDMSLARGLDYYTGIIYEAVT 373

  Fly   386 KGESATVASPA---KTSQQNGEQANEPAT-VGSVAGGGRYDNLVGMFDPRGKA-VPCVGVSIGVE 445
            :..:..:.|.|   |::....:::|:.:. |||:|.|||||||||||..:..| :||||:|:|:|
pombe   374 EASAPKIKSSAEKKKSADPEADRSNDDSIGVGSIAAGGRYDNLVGMFAAKKNAKIPCVGISLGLE 438

  Fly   446 RIFSVLEARAAASGLKLRTSDVEVYV-----ASAHKGLHEQRLKVLNLLWDAGVKAEHSYKLNPK 505
            ||||:|  |:......:|.:||:|:|     .....|..::|:.|...||..|:|||..||:.||
pombe   439 RIFSIL--RSKIPDEDIRANDVDVFVMAFGGGKEWTGFLKERMSVCKDLWANGIKAEFLYKVKPK 501

  Fly   506 LLVQLQHCEEHQIPLVVVLGDAELAQGLVKLREVTTREETN----VKLEDLAAEIRR 558
            ...|....::..:|..|:||..|.|:|.|:::::..:|.::    |..|::.:.:::
pombe   502 PRQQFDAADKFDVPFAVILGQDEFAKGSVRIKQMGLKENSDEGQLVPREEMVSVLKK 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisRS	NP_573305.2	S15_NS1_EPRS_RNA-bind	6..92	CDD:294248	25/86 (29%)
		HisS	98..561	CDD:223202	249/479 (52%)
		HisRS-like_core	114..452	CDD:238396	206/343 (60%)
		HisRS_anticodon	467..557	CDD:238436	28/98 (29%)
hrs1	NP_596441.2	WHEP-TRS	33..>62	CDD:278865	16/70 (23%)
		HisS	86..561	CDD:223202	248/475 (52%)
		HisRS-like_core	101..444	CDD:238396	206/342 (60%)
		HisRS_anticodon	458..557	CDD:238436	28/98 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	369	1.000	Domainoid score	I141
eggNOG	1	0.900	-	-		E1_COG0124
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1592
Inparanoid	1	1.050	503	1.000	Inparanoid score	I241
OMA	1	1.010	-	-		QHG55859
OrthoFinder	1	1.000	-	-		FOG0001634
OrthoInspector	1	1.000	-	-		oto101356
orthoMCL	1	0.900	-	-		OOG6_100351
Panther	1	1.100	-	-	LDO	PTHR11476
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1442
SonicParanoid	1	1.000	-	-		X1525
TreeFam	1	0.960	-	-
	14	13.860