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Protein Alignment HisRS and HARS2

DIOPT Version :9

Sequence 1:	NP_573305.2	Gene:	HisRS / 32841	FlyBaseID:	FBgn0027087	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001350464.1	Gene:	HARS2 / 23438	HGNCID:	4817	Length:	512	Species:	Homo sapiens

Alignment Length:	499	Identity:	276/499 - (55%)
Similarity:	356/499 - (71%)	Gaps:	20/499 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 QQQHEQLHQIDEEVARLLALKATLGGDAAPTNQKFTLKTPKGTRDYGPQQMTLRQGVLDKIVQVF 129
            |.|.|:..|:.|.|     |.:.|.......|  |.:||||||||..||.|.:|:.:||.::..|
Human    34 QSQGEESLQVAEAV-----LTSQLKAHQEKPN--FIIKTPKGTRDLSPQHMVVREKILDLVISCF 91

  Fly   130 KRHGGEAIDTPVFELKEVLTGKYGEDSKLIYDLKDQGGEILSMRYDLTVPLARYLAMNKISSIKR 194
            ||||.:.:|||.|||||.||.||||||.|:|||||||||:||:|||||||.||||||||:..:||
Human    92 KRHGAKGMDTPAFELKETLTEKYGEDSGLMYDLKDQGGELLSLRYDLTVPFARYLAMNKVKKMKR 156

  Fly   195 YHIAKVYRRDNPAMTKGRYREFYQCDFDIAGTYDPMLPDAECVKIVSEILDTLDIGDYVIKLNHR 259
            ||:.||:||::|.:.:||||||.||||||||.:|||:|||||:||:.|||..|.:||::||:|.|
Human   157 YHVGKVWRRESPTIVQGRYREFCQCDFDIAGQFDPMIPDAECLKIMCEILSGLQLGDFLIKVNDR 221

  Fly   260 QLLDGMFQACGVPADSFRTICSAVDKLDKSPWADVRKEMVDEKGLDEAAADRIGEYVRLSGGAEL 324
            :::||||..||||...||.|||::|||||..|.|||.|||.:|||....|||||:||:..||..|
Human   222 RIVDGMFAVCGVPESKFRAICSSIDKLDKMAWKDVRHEMVVKKGLAPEVADRIGDYVQCHGGVSL 286

  Fly   325 VEQLLANEKLKAVPNAVKGLEGMKQLLKYCSIFGLDKRVSFDLSLARGLDYYTGVIYEGVLKGES 389
            |||:..:.:|.....|::||..:|.|.:|.::||:..::|||||||||||||||||||.||
Human   287 VEQMFQDPRLSQNKQALEGLGDLKLLFEYLTLFGIADKISFDLSLARGLDYYTGVIYEAVL---- 347

  Fly   390 ATVASPAKTSQQNGEQANEPATVGSVAGGGRYDNLVGMFDPRGKAVPCVGVSIGVERIFSVLEAR 454
                  .:|..|.||   ||..|||||.|||||.|||||||:|..|||||:||||||||.::|.|
Human   348 ------LQTPTQAGE---EPLNVGSVAAGGRYDGLVGMFDPKGHKVPCVGLSIGVERIFYIVEQR 403

  Fly   455 AAASGLKLRTSDVEVYVASAHKGLHEQRLKVLNLLWDAGVKAEHSYKLNPKLLVQLQHCEEHQIP 519
            ....|.|:||::.:|:||:..|...::|||::..|||:|:|||..||.|||||.||.:||...||
Human   404 MKTKGEKVRTTETQVFVATPQKNFLQERLKLIAELWDSGIKAEMLYKNNPKLLTQLHYCESTGIP 468

  Fly   520 LVVVLGDAELAQGLVKLREVTTREETNVKLEDLAAEIRRRQQAS 563
            |||::|:.||.:|::|:|.|.:|||..:|.|:..|||::|...|
Human   469 LVVIIGEQELKEGVIKIRSVASREEVAIKRENFVAEIQKRLSES 512

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.