DRSC/TRiP Functional Genomics Resources

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Protein Alignment HisRS and Eif2ak1

DIOPT Version :9

Sequence 1:NP_573305.2 Gene:HisRS / 32841 FlyBaseID:FBgn0027087 Length:564 Species:Drosophila melanogaster
Sequence 2:NP_038585.2 Gene:Eif2ak1 / 15467 MGIID:1353448 Length:619 Species:Mus musculus


Alignment Length:433 Identity:77/433 - (17%)
Similarity:133/433 - (30%) Gaps:151/433 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   146 EVLTGKYGEDSKLIYDLKDQGG----------EILSMRYDLTVPLARYLAMNKISSIKRYHIAKV 200
            |||:.:.|:        :||||          ....:..:...|.......|:.:::..|....|
Mouse   254 EVLSEQEGD--------RDQGGVKDNESSSSIVFAELTPEKEKPFGESEVKNENNNLVSYTANLV 310

  Fly   201 YRRDNPAMTKGRYREFYQCDFDIAGTYDPMLPDAECVKIVSEILDTLDIGDYVIKLNHRQLLDGM 265
            .|..:.:.:....:|....|..:.......||                       |.|...|:|.
Mouse   311 VRNSSESESSIELQEDGLTDLSVRPVVRHQLP-----------------------LGHSSELEGN 352

  Fly   266 FQACGVPADSFRTICSAVD--------------KLDKSPWADVRKEMVDEKGLDEAAADRIGEYV 316
            |.:....::....:....:              :|....|...|.:...|. :||||.    .||
Mouse   353 FTSTDESSEGNLNLLGQTEVRYHLMLHIQMQLCELSLWDWITERNKRSREY-VDEAAC----PYV 412

  Fly   317 RLSGGAELVEQLLANEKLKAVPNAVKGLEGMKQL------LKYCSIF--GLDKRVSF-DLSLARG 372
            ..|...::.::|            |:|:..:..:      ||..:||  |.|::|.. |..||  
Mouse   413 MASVATKIFQEL------------VEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLA-- 463

  Fly   373 LDYYTGVIYEGVLKGESATVASPAKTSQQNGE-QANEPATVGSV-------AGGGRYDN------ 423
                            .|.:...|..:.:||: .....:.||:.       ..|.:||.      
Mouse   464 ----------------CADIIQNADWTNRNGKGTRTHTSRVGTCLYASPEQLEGSQYDAKSDMYS 512

  Fly   424 ----LVGMFDPRG----KAVPCVGVSIGVERIFSVLEARAAA-----------------SGLKLR 463
                |:.:|.|.|    :|....||..|  ||...|..|...                 |.|:|.
Mouse   513 LGVILLELFQPFGTEMERATVLTGVRTG--RIPESLSKRCPVQAKYIQLLTGRNVSQRPSALQLL 575

  Fly   464 TSD-----------VEVYVASAHKGLHEQRLKVLNLLWDAGVK 495
            .|:           :::.:....|.:.|.:.::..|..|.|:|
Mouse   576 QSELFQTTGNVNLTLQMKIIEQEKEIEELKKQLSLLSQDRGLK 618

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HisRSNP_573305.2 S15_NS1_EPRS_RNA-bind 6..92 CDD:294248
HisS 98..561 CDD:223202 77/433 (18%)
HisRS-like_core 114..452 CDD:238396 65/360 (18%)
HisRS_anticodon 467..557 CDD:238436 6/29 (21%)
Eif2ak1NP_038585.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40
STKc_EIF2AK1_HRI 160..578 CDD:270951 70/391 (18%)
Pkinase 167..580 CDD:278497 71/393 (18%)
HRM 1 408..413 2/8 (25%)
HRM 2 549..554 1/4 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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