DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HisRS and AgaP_AGAP010925

DIOPT Version :9

Sequence 1:	NP_573305.2	Gene:	HisRS / 32841	FlyBaseID:	FBgn0027087	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_309768.4	Gene:	AgaP_AGAP010925 / 1271026	VectorBaseID:	AGAP010925	Length:	643	Species:	Anopheles gambiae

Alignment Length:	428	Identity:	81/428 - (18%)
Similarity:	142/428 - (33%)	Gaps:	120/428 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 DLTVPLARYLAMNKISSIKRYHIAKVYR-RDNPAMT---------------KGRYREFYQCDFDI 223
            |.|..:..:..|........||:..:.| ||.|.:.               ...||||.:..|..
Mosquito   110 DETYTMGEFEMMRSQYQKALYHLVSIARGRDLPVVLPDLQEYWPLPAGLEWSRYYREFEELSFIA 174

  Fly   224 AGTY----------DPMLPDAECVKI----VSEILDTLDIGDYVIKLNHRQLLDGMFQACGV--- 271
            .|.:          |.::...:.|.|    :..:|..|.....:..|||..::.  ::|..:
Mosquito   175 GGGFGKVYRSRNKLDDIVYAVKKVTIRSTTIKNVLVHLAEVKTLASLNHINIVP--YKAAWLEPL 237

  Fly   272 --PADSFRTICSAVDKLDKSPWADVRKEMVDEKGL---------DEAAADRIGEYVRLSGGAELV 325
              |..:.....|.:|:.|.|..::..:|..|.:|.         .|..:|........|.|.|..
Mosquito   238 MSPGKNSVNSTSTMDEADGSGSSEEEEEDEDGEGTRDISDSLRRPEHDSDEFSILFERSNGEEQQ 302

  Fly   326 EQLLANE------KLKAVPNAVKGLEGMKQ--LLKYCSIF------------GLDKRVSFDLSLA 370
            ||..:.|      :::....:|..:|..:.  .||:.:::            .||:|.:.|
Mosquito   303 EQESSEEARNQIAEVEETSRSVVSIEESQAHINLKWATLYIQMTLCHLTLREWLDQRNATD---- 363

  Fly   371 RGLDYYTGVIYEGVLKGESATVAS-PAKTSQQNGEQANEPATVGSVAGGGRYDNLVGMFD----P 430
            ...::|...::.. |..|...|.| |..:..:...|.::.....||           :||    .
Mosquito   364 NFTEFYADFLHNR-LHNELGIVNSIPRNSFCRQSSQISDTTNTDSV-----------LFDRESPV 416

  Fly   431 RGKAVPCVGVSI---GVERIFSVLEARAAASGLKLRTSDVEVYVASAHKGLHEQRLKVLNLLWDA 492
            |..:.|....|:   .|:.:..|::                         :.:|.|..||.:...
Mosquito   417 RRNSEPSKDDSLTDGHVQHLDIVID-------------------------VFQQLLNGLNYIHSR 456

  Fly   493 GVKAEHSYKLNPKLLVQLQHCEEHQIPLVVVLGDAELA 530
            |: ..|..|.: .:.|.|.|   |...|.:.|||..||
Mosquito   457 GI-VHHDIKPS-NIFVSLSH---HDSKLCIQLGDFGLA 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HisRS	NP_573305.2	S15_NS1_EPRS_RNA-bind	6..92	CDD:294248
		HisS	98..561	CDD:223202	81/428 (19%)
		HisRS-like_core	114..452	CDD:238396	64/348 (18%)
		HisRS_anticodon	467..557	CDD:238436	17/64 (27%)
AgaP_AGAP010925	XP_309768.4	PKc_like	160..>493	CDD:304357	72/378 (19%)
		SPS1	166..>230	CDD:223589	12/65 (18%)
		PKc_like	<434..565	CDD:304357	18/86 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900