DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HisRS and Eif2ak4

DIOPT Version :9

Sequence 1:NP_573305.2 Gene:HisRS / 32841 FlyBaseID:FBgn0027087 Length:564 Species:Drosophila melanogaster
Sequence 2:NP_001099214.2 Gene:Eif2ak4 / 114859 RGDID:1311439 Length:1649 Species:Rattus norvegicus


Alignment Length:573 Identity:141/573 - (24%)
Similarity:236/573 - (41%) Gaps:128/573 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 PAQRQQQQQ--------PQKQQQAQVQQQQHEQLHQIDEEVARLL-----------ALKATLGGD 91
            ||:|....:        |.:.:::::.:..|..|...|.:..|.:           |:..|...|
  Rat   986 PAKRPTAMELLKSELLPPPQMEESELHEVLHHTLANTDGKAYRTMMSQLFCQHSSPAIDYTYDSD 1050

  Fly    92 AAPTNQKFTLKTPKGTRDYGPQQMTLRQGVLDKIVQVFKRHGGEAIDTPVFELKEVLTGKYGEDS 156
            ....|  |.::|.|           ::|.|.:.||:||||||...:.||:...:          :
  Rat  1051 ILKGN--FLIRTAK-----------IQQLVCETIVRVFKRHGAVQLCTPLLLPR----------N 1092

  Fly   157 KLIYD------LKDQGGEILSMRYDLTVPLARYLAMNKISSIKRYHIAKVYR-----RDNPAMTK 210
            :.||:      ..|..|.::.:.:||.||.|||:|.|.|.::|||.|.:|:|     |.:|    
  Rat  1093 RQIYEHNEAALFMDHSGMLVMLPFDLRVPFARYVARNNILNLKRYCIERVFRPRKLDRFHP---- 1153

  Fly   211 GRYREFYQCDFDI-AGTYDPMLPDAECVKIVSEILD---TLDIGDYVIKLNHRQLLDGMFQACGV 271
               :|..:|.||| ..|.:..||.||.:..:.|::.   .|...:|.|.|||..||..:...||:
  Rat  1154 ---KELLECAFDIVTSTANSSLPTAETIYTIYEVIQEFPALQERNYSIYLNHTMLLKAILLHCGI 1215

  Fly   272 PADSFRTIC-----SAVDKLDKSPWADVRKEMVDEK----GLDEAAADRIGEYVRLSGGAELVEQ 327
            |.|....:.     :..:||       .|:| |:.|    .|...:..|:.:::...|..:    
  Rat  1216 PEDKLSQVYVILYDAVTEKL-------TRRE-VEAKFCNLSLSSNSLCRLYKFIEQKGDLQ---- 1268

  Fly   328 LLANEKLKAVPNAVKGLEGMKQLLKYC-----SIFGLDKRVSFDLSLARGLDYYTGVIYEGVLKG 387
                :....:.:.:|...|:.||:||.     .:.||.|::...|.::..|    |::|      
  Rat  1269 ----DLTPTINSLIKQKTGIAQLVKYSLKDLEEVVGLLKKLGVKLQVSINL----GLVY------ 1319

  Fly   388 ESATVASPAKTSQQNG--------EQANEPATVGSVAGGGRYDNLVGMF-DPR--GKAVPCVGVS 441
                     |..|.||        .:..:......:|.|||||.|:..| .|:  |.....||||
  Rat  1320 ---------KVQQHNGIIFQFLAFSKRRQRVVPEILAAGGRYDLLIPKFRGPQALGPVPTAVGVS 1375

  Fly   442 IGVERIFSVLEARAAASGLKLRTSDVEVYVASAHKGLHEQRLKVLNLLWDAGVKAEHSYKLNPKL 506
            |.:::||    |.....|..:..|..::.|.||.:....:.:.:...||.||:.||..|..:...
  Rat  1376 IAIDKIF----AAVLNMGEPVTVSSCDLLVVSAGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQ 1436

  Fly   507 LVQLQHCEEHQIPLVVVLGDAELAQGLVKLREVTTREETNVKLEDLAAEIRRR 559
            ....::|..|:|..|.::.|.|.:...||..|...:.|..|...||...:.::
  Rat  1437 EELQEYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLESDLVDHVMQK 1489

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HisRSNP_573305.2 S15_NS1_EPRS_RNA-bind 6..92 CDD:294248 10/64 (16%)
HisS 98..561 CDD:223202 129/502 (26%)
HisRS-like_core 114..452 CDD:238396 100/377 (27%)
HisRS_anticodon 467..557 CDD:238436 23/89 (26%)
Eif2ak4NP_001099214.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
RWD 26..137 CDD:214735
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 227..260
Pkinase 289..539 CDD:278497
PK_eIF2AK_GCN2_rpt1 299..538 CDD:270914
STKc_EIF2AK4_GCN2_rpt2 583..999 CDD:270948 3/12 (25%)
S_TKc 590..1001 CDD:214567 3/14 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 662..785
Histidyl-tRNA synthetase-like. /evidence=ECO:0000250|UniProtKB:Q9QZ05 1022..1493 135/537 (25%)
HisS 1050..1486 CDD:223202 131/504 (26%)
class_II_aaRS-like_core 1061..1385 CDD:294192 102/390 (26%)
HGTP_anticodon 1396..1486 CDD:294191 23/89 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.