DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HisRS and hars1

DIOPT Version :9

Sequence 1:	NP_573305.2	Gene:	HisRS / 32841	FlyBaseID:	FBgn0027087	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_031754604.1	Gene:	hars1 / 100489846	XenbaseID:	XB-GENE-6073789	Length:	515	Species:	Xenopus tropicalis

Alignment Length:	500	Identity:	276/500 - (55%)
Similarity:	357/500 - (71%)	Gaps:	19/500 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 AQVQQQQHEQLHQIDEEVARLLALKATLGGDAAPTNQK-FTLKTPKGTRDYGPQQMTLRQGVLDK 124
            |.|....:...|..|:.     .:.|...|.|.|..|| |.|||||||.|..|:||.:|:.||..
Frog    22 ACVASVPYRSYHPSDQP-----TIDAVEDGIAQPEVQKHFVLKTPKGTHDVHPKQMAIRERVLST 81

  Fly   125 IVQVFKRHGGEAIDTPVFELKEVLTGKYGEDSKLIYDLKDQGGEILSMRYDLTVPLARYLAMNKI 189
            :|..|||||.|.||||||||||.|||||||||||||||||||||:||:|||||||.||:||||||
Frog    82 VVNCFKRHGAETIDTPVFELKETLTGKYGEDSKLIYDLKDQGGELLSLRYDLTVPFARFLAMNKI 146

  Fly   190 SSIKRYHIAKVYRRDNPAMTKGRYREFYQCDFDIAGTYDPMLPDAECVKIVSEILDTLDIGDYVI 254
            :::|||||.||||||.||  :|||||||||||||||.:|||:|||||:||:.|||..|::|::.|
Frog   147 TNMKRYHIGKVYRRDKPA--RGRYREFYQCDFDIAGHHDPMIPDAECLKILHEILTELELGNFRI 209

  Fly   255 KLNHRQLLDGMFQACGVPADSFRTICSAVDKLDKSPWADVRKEMVDEKGLDEAAADRIGEYVRLS 319
            |:|.|:||.|:...||||...|||:|:::|||||.||..||:|::::|.|:....::||:|:||:
Frog   210 KVNDRRLLIGILTVCGVPEAKFRTVCTSIDKLDKIPWDSVRRELIEDKELEAETVEQIGKYIRLN 274

  Fly   320 GGAELVEQLLANEKLKAVPNAVKGLEGMKQLLKYCSIFGLDKRVSFDLSLARGLDYYTGVIYEGV 384
            ||..|:|.|..:.||.....|::||..:|.|.||..|||:..::.:||.||||||||||||||.|
Frog   275 GGLPLLEHLWDDPKLSQNNLAMEGLRDLKLLNKYSEIFGVTDKIVYDLGLARGLDYYTGVIYEAV 339

  Fly   385 LKGESATVASPAKTS-QQNGEQANEPATVGSVAGGGRYDNLVGMFDPRGKAVPCVGVSIGVERIF 448
            |      :.:|.... :|||....    .||||||||||.|||||||:.:||||||:|||:||:|
Frog   340 L------LQNPGGPHVRQNGHSEE----YGSVAGGGRYDGLVGMFDPKDRAVPCVGLSIGIERMF 394

  Fly   449 SVLEARAAASGLKLRTSDVEVYVASAHKGLHEQRLKVLNLLWDAGVKAEHSYKLNPKLLVQLQHC 513
            .:||.:...|..|::|:|.:|.|.||.|...|:::|::..||::|::||..||.|||.|.||.:|
Frog   395 MLLEKKYKNSKEKIQTTDTQVLVVSAQKKFLEEKMKLIAALWNSGIRAEMFYKENPKFLSQLHYC 459

  Fly   514 EEHQIPLVVVLGDAELAQGLVKLREVTTREETNVKLEDLAAEIRR 558
            ||..|||||::|:.||..|:||||.||||||.:|..|::..|||:
Frog   460 EERGIPLVVIVGEQELQAGVVKLRIVTTREEVSVSKENVIEEIRK 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HisRS	NP_573305.2	S15_NS1_EPRS_RNA-bind	6..92	CDD:294248	6/30 (20%)
		HisS	98..561	CDD:223202	267/462 (58%)
		HisRS-like_core	114..452	CDD:238396	203/338 (60%)
		HisRS_anticodon	467..557	CDD:238436	45/89 (51%)
hars1	XP_031754604.1	PLN02972	<33..505	CDD:215525	274/488 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	414	1.000	Domainoid score	I666
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H1592
Inparanoid	1	1.050	627	1.000	Inparanoid score	I844
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1065556at2759
OrthoFinder	1	1.000	-	-		FOG0001634
OrthoInspector	1	1.000	-	-		otm48659
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1525
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060