Protein Alignment HisRS and hars2

DIOPT Version :10

• Sequence 1: NP_573305.2
• Gene: HisRS / 32841
• FlyBaseID: FBgn0027087
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_031754386.1
• Gene: hars2 / 100488813
• XenbaseID: XB-GENE-5941573
• Length: 509
• Species: Xenopus tropicalis
• Alignment Length: 561
• Identity: 324/561 - (57%)
• Similarity: 401/561 - (71%)
• Gaps: 54/561 - (9%)

  Fly     1 MSDTREQILEQIKVQGDLVRQLKAAKESKEKTAPSGGGRVSSSGVPAQRQQQQQPQKQQQAQVQQ 65
            |:| |.::.:.:.:||:.||:||..|.|.|
 Frog     1 MAD-RAELEKAVTLQGEKVRKLKQDKASSE----------------------------------- 29

  Fly    66 QQHEQLHQIDEEVARLLALKATLGGDAAPTNQKFTLKTPKGTRDYGPQQMTLRQGVLDKIVQVFK 130
                   :|.||||:||.|||.||.|..  ..||.||||||||||.|:|..:|:.|.:.|::.||
 Frog    30 -------EIAEEVAKLLELKARLGTDEG--KHKFVLKTPKGTRDYNPKQTAIREKVFNTIIKCFK 85

  Fly   131 RHGGEAIDTPVFELKEVLTGKYGEDSKLIYDLKDQGGEILSMRYDLTVPLARYLAMNKISSIKRY 195
            |||.|.||||||||||.|||||||||||||||||||||:||:|||||||.|||||||||::||||
 Frog    86 RHGAETIDTPVFELKETLTGKYGEDSKLIYDLKDQGGELLSLRYDLTVPFARYLAMNKINNIKRY 150

  Fly   196 HIAKVYRRDNPAMTKGRYREFYQCDFDIAGTYDPMLPDAECVKIVSEILDTLDIGDYVIKLNHRQ 260
            ||||||||||||||:|||||||||||||||.:|||:|||||:|||.|||..||:|:::||:|.|:
 Frog   151 HIAKVYRRDNPAMTRGRYREFYQCDFDIAGQFDPMIPDAECLKIVHEILSELDLGEFLIKVNDRR 215

  Fly   261 LLDGMFQACGVPADSFRTICSAVDKLDKSPWADVRKEMVDEKGLDEAAADRIGEYVRLSGGAELV 325
            :|||||..||||...||||||:||||||:||.||:.|||.||||...|||:||:||:.:||.:|:
 Frog   216 ILDGMFAVCGVPDSKFRTICSSVDKLDKTPWEDVKNEMVGEKGLAPEAADQIGDYVQRNGGLDLI 280

  Fly   326 EQLLANEKLKAVPNAVKGLEGMKQLLKYCSIFGLDKRVSFDLSLARGLDYYTGVIYEGVLKGESA 390
            |||:.:.||.....|::||..||.|.:|..:|.:..:||||||||||||||||||||.||
 Frog   281 EQLINDPKLSQNKLALEGLSDMKTLFQYLELFAVTDKVSFDLSLARGLDYYTGVIYEAVL----- 340

  Fly   391 TVASPAKTSQQNGEQANEPATVGSVAGGGRYDNLVGMFDPRGKAVPCVGVSIGVERIFSVLEARA 455
                .....||..:.|.|..:|||||||||||.|||||||:|:.|||||||||:|||||::|.:|
 Frog   341 ----VQNEPQQQNDHAEEAVSVGSVAGGGRYDGLVGMFDPKGRKVPCVGVSIGIERIFSIMEQKA 401

  Fly   456 AASGLKLRTSDVEVYVASAHKGLHEQRLKVLNLLWDAGVKAEHSYKLNPKLLVQLQHCEEHQIPL 520
            .||..|:||::.:|.||:|.|.|.|:|:|:::.||:||:|||..||.|||||.|||:|||..|||
 Frog   402 EASEEKIRTTETQVLVAAAQKKLLEERMKLISELWNAGIKAEMLYKKNPKLLNQLQYCEETGIPL 466

  Fly   521 VVVLGDAELAQGLVKLREVTTREETNVKLEDLAAEIRRRQQ 561
            |.::|:.||..|:||||.|.||||.:|..::|..||.:|.|
 Frog   467 VAIIGEQELKDGVVKLRVVATREEVDVARQNLVEEIHKRTQ 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisRS	NP_573305.2	S15_NS1_EPRS_RNA-bind	6..92	CDD:469733	21/85 (25%)
		PLN02972	<102..559	CDD:215525	294/456 (64%)
hars2	XP_031754386.1	HisRS_RNA	5..49	CDD:238474	21/85 (25%)
		PLN02972	<57..502	CDD:215525	292/453 (64%)