Protein Alignment HSD3B2 and CG7724

DIOPT Version :10

• Sequence 1: NP_000189.1
• Gene: HSD3B2 / 3284
• HGNCID: 5218
• Length: 372
• Species: Homo sapiens
• Sequence 2: NP_648957.1
• Gene: CG7724 / 39918
• FlyBaseID: FBgn0036698
• Length: 398
• Species: Drosophila melanogaster
• Alignment Length: 402
• Identity: 115/402 - (28%)
• Similarity: 190/402 - (47%)
• Gaps: 53/402 - (13%)

Human     6 LVTGAGGLLGQRIVRLLVEEKE---LKEIRALD-KAFRPEL-REEFSKLQNRTKLTVLEGDILDE 65
            ||||..|.|||.:::.|:|.||   :||||:|| ..::..: .||.|.|  ||.:..:.||:
  Fly    10 LVTGGSGFLGQHLIKQLLERKEELGIKEIRSLDIVPYKNNIGHEETSLL--RTYVADIGGDL--- 69

Human    66 PFLKRACQDVSVVIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVPVFIYTSSIEVA-- 128
            ..|......|..|.|.|..:.:....:.|.:..|||.||..:::.|:|.:|...:|||...|.
  Fly    70 KALSPIFNGVDGVFHCAASVKIEYPPNYEELERVNVNGTLAVVDLCIQNNVKRLVYTSCTSVCFV 134

Human   129 ---GPNSYKEIIQNGHEEEPL-----------ENTWPTP-YPYSKKLAEKAVLAANGWNLKN-GD 177
               |.:::..:|.:...:...           :|.:..| |..||..||..||.:||..|.| .:
  Fly   135 PFKGRSTFSAVINSTESKTDTPTLDSSTLWEQDNQFLIPGYASSKLRAENIVLNSNGAPLHNQKE 199

Human   178 TLYTCALRPTYIYGEGGPFLSASINEALNNNG----ILSSVGKFSTVNPVYVGNVAWAHILALRA 238
            .|.|.|:|....|||........|.:.|:..|    .::.||....:  ||.|||||.||.|.:|
  Fly   200 YLATSAMRAPLTYGECDSHFITEIFDFLSTRGWVFPRIAGVGGKQQL--VYAGNVAWGHICAYKA 262

Human   239 LRDPKKAPSVRGQFYYISDDTPHQSYDNLN---------YILSKEFGLRLDSRWSLPLTLMYWIG 294
            |:...||  |.|...:::|||      .:|         .:|.:.|.:: .|.|.:|..|.:::.
  Fly   263 LKVSDKA--VNGLPVFVTDDT------GINDVSRFVQKMAVLGERFKVK-TSWWYVPHFLFFFLA 318

Human   295 FLLEVVSFLLSPIYSYQPPFN-RHTVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAKQKTVEWVGS 358
            ||||||..:..|...|:..:: |...:.::|:..::..:|...:.|.||:..:.:.:::.:|..:
  Fly   319 FLLEVVVRVAYPYTKYRLRYSLRAIASYTSSMLMYNRLRASIHMDYMPLFDPDASAERSAKWYAT 383

Human   359 LVDRHKETLKSK 370
            ..|:.::..|.|
  Fly   384 WWDQRQQAQKLK 395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSD3B2	NP_000189.1	3b-HSD_HSDB1_like_SDR_e	4..356	CDD:187671	111/386 (29%)
CG7724	NP_648957.1	Rossmann-fold NAD(P)(+)-binding proteins	8..381	CDD:473865	111/386 (29%)