DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ggt-1 and ggt1b

DIOPT Version :9

Sequence 1:	NP_001285408.1	Gene:	Ggt-1 / 32839	FlyBaseID:	FBgn0030932	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	XP_697468.3	Gene:	ggt1b / 569014	ZFINID:	ZDB-GENE-110408-13	Length:	574	Species:	Danio rerio

Alignment Length:	584	Identity:	249/584 - (42%)
Similarity:	345/584 - (59%)	Gaps:	47/584 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLWLLLAALMVTALTLGLVFGLKNR------DTLYISGAVVSNGIGCAAVGGEMLTDGGSAVDAA 68
            |:.|||||:   ...|.:.|.::.:      ::.:...||.::...|:.:|.::|..||||||:|
Zfish    10 LVLLLLAAV---GTFLAVFFSVQGKKASSDPESGFFKAAVATDAGTCSEIGRDVLKKGGSAVDSA 71

  Fly    69 IATLLCEGLLLPHSMGIGGGFVATIYTRSSRKVETVIARESAPAAAHKDMFVGETSIT--GAKSG 131
            ||.|||.||:..||||||||...|||...:.|.||:.|||:|||.|.:|||...|.::  |..|.
Zfish    72 IAALLCAGLMNAHSMGIGGGLFFTIYDAKTGKAETINARETAPANATRDMFGNSTELSQKGGLSI 136

  Fly   132 AVPGEILGYWEMHRRYGILPWKRLFEPSIKLAREGHVVSRYLAAAIQSKLDNIKADPGLSAVFLN 196
            ||||||.||...|||:|.||||.||.|||||||:|..|.|.||:||:|..:||..|..|.:||.|
Zfish   137 AVPGEIRGYEMAHRRHGRLPWKELFLPSIKLARDGFPVGRALASAIRSNRNNILEDKMLCSVFCN 201

  Fly   197 ATGDPHLEGDYMKRPALADTLERIAENGAKEFYDGGETGRKFVEDIQKMGGIITEQDLRDYTVRW 261
            :||:...|.|.:....||||.|.|||.|.:.||.|. .....|.|||...||||..|||||  |.
Zfish   202 STGNILQENDTITFTKLADTYEAIAEQGPEAFYSGA-LAESLVRDIQDADGIITLADLRDY--RA 263

  Fly   262 ESDGHVSAHVSGTYTLYSTPMPSSGPVLAFILNLMADL--------YTDNEPIYWQRVVEAFKHA 318
            ..|.:......|.:|:.:...|||||||..:||:::..        .|:.:.:.:.||||||:.|
Zfish   264 LLDEYPPTASVGEFTMVTPDAPSSGPVLTLMLNILSGYSLSPDSVSSTEKKILTYHRVVEAFRFA 328

  Fly   319 YGQRTNLGDMYADPVSAASINATLEEMLKPEFLESVRKLIHDNSTSEDYLYYGANFTVEEDHGTA 383
            |.:|:.|||     ....:|:..::.:....:.:.:|..|.||||.:: .||...|.:.|::||:
Zfish   329 YAKRSVLGD-----PQFLNISDFIQNITSKGYADMIRLKITDNSTQQE-SYYEPEFYLPENYGTS 387

  Fly   384 HMNVLATNGDAVSITSTINNYFGSKVASTQTGIILNDEMDDFSTPGVINGFGVPASPANYIYPGK 448
            |::|:|.:|.||:.|||||.|||||:.|..|||:||:||||||:|.:.|.||||.||.|:|.|.|
Zfish   388 HVSVVAEDGSAVAATSTINTYFGSKLMSKSTGILLNNEMDDFSSPLITNNFGVPPSPNNFIVPNK 452

  Fly   449 RPMSSMSPCIIVDQEGNVRLLVGAAGGTRITTSVAAVIMKYLLRKESLTAAVNNGRLHHQLAPMR 513
            ||||||.|.|::|:...|:::|||:|||:|||:||.|::..|..:..|..|:...|:|:||:|..
Zfish   453 RPMSSMCPAILLDKNNQVKMVVGASGGTKITTAVAQVVLNTLFFQYDLKKAIAEARVHNQLSPNT 517

  Fly   514 VSYEQEVDSSVTDYLKQVGHEMYEEPVGSSFAAV-TAIGALEQPEPFY--------DRRRIGSA 568
            ...||..|.:|.:.|.:..|          |..| |::||:.|....|        |.|:.|.|
Zfish   518 TQVEQSFDKAVLEGLAEKNH----------FTEVFTSMGAVVQAVARYSEGLSAESDPRKGGYA 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ggt-1	NP_001285408.1	G_glu_transpept	56..566	CDD:279371	235/528 (45%)
ggt1b	XP_697468.3	G_glu_transpept	59..569	CDD:279371	235/528 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579878
Domainoid	1	1.000	396	1.000	Domainoid score	I724
eggNOG	1	0.900	-	-		E1_COG0405
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	408	1.000	Inparanoid score	I1854
OMA	1	1.010	-	-		QHG58031
OrthoDB	1	1.010	-	-		D1419292at2759
OrthoFinder	1	1.000	-	-		FOG0000229
OrthoInspector	1	1.000	-	-		mtm6378
orthoMCL	1	0.900	-	-		OOG6_100578
Panther	1	1.100	-	-	O	PTHR11686
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X210
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770