DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ggt-1 and ggt1l2.2

DIOPT Version :9

Sequence 1:	NP_001285408.1	Gene:	Ggt-1 / 32839	FlyBaseID:	FBgn0030932	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	XP_009294029.1	Gene:	ggt1l2.2 / 566746	ZFINID:	ZDB-GENE-090312-37	Length:	566	Species:	Danio rerio

Alignment Length:	553	Identity:	221/553 - (39%)
Similarity:	319/553 - (57%)	Gaps:	35/553 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLAALMVTALTLGLVFGLKNRDTLYISGAVVSNGIGCAAVGGEMLTDGGSAVDAAIATLLCEGLL 78
            ::|:|::..:.:.:|..:...:|.|.:.||.::...|:.:|.::|...|||||||||.|||..|:
Zfish    13 MVASLVIIVIVILIVVRIVLSNTCYDNAAVAADARKCSEIGRDILQRNGSAVDAAIAALLCVSLV 77

  Fly    79 LPHSMGIGGGFVATIYTRSSRKVETVIARESAPAAAHKDMFVGETSITGAKSG---AVPGEILGY 140
            ...|||||||.|.|||...|.||||:.:||:||.:|.::||  .|:...||.|   |||||:.||
Zfish    78 NAQSMGIGGGLVFTIYNAPSGKVETINSRETAPMSASENMF--GTNPEKAKPGLFIAVPGELRGY 140

  Fly   141 WEMHRRYGILPWKRLFEPSIKLAREGHVVSRYLAAAIQSKLDNIKADPGLSAVFLNATGDPHLEG 205
            ...|:|:|.||||.||:||||||.||..:.:.||.||......|:.:..|..||.::......|.
Zfish   141 ALAHKRHGKLPWKELFQPSIKLASEGFKIGKALANAINETRATIQRNATLCEVFCDSNNIVLKEN 205

  Fly   206 DYMKRPALADTLERIAENGAKEFYDGGETGRKFVEDIQKMGGIITEQDLRDY-TVRWESDGHVSA 269
            |.::.|.||:|..:|:|.|...||:|..| :..|:||:..|||||.:||:.| .|..|   |...
Zfish   206 DTIRFPKLAETYRKISEEGPDAFYNGSLT-QSIVDDIKAAGGIITREDLKAYGPVLTE---HALN 266

  Fly   270 HVSGTYTLYSTPMPSSGPVLAFILNLM--------ADLYTDNEPIYWQRVVEAFKHAYGQRTNLG 326
            ...|.|..::...|..|||||.||.:|        :...|.|:.:.:.|::|||:.|..|::.||
Zfish   267 FTVGKYIFHAPGAPFGGPVLALILKVMKGYNISWKSMATTGNKTLTYHRLIEAFRFADVQKSKLG 331

  Fly   327 DMYADPVSAASINATLEEMLKPEFLESVRKLIHDNSTSEDYLYYGANFTVEEDHGTAHMNVLATN 391
            |...:     :|...::.|:...|.:.:|..|.|:.....|.......||.|||||:|::|||.:
Zfish   332 DPLFE-----NITEHVKNMVSDSFADHIRSKIKDDLKQTSYDEQEDINTVPEDHGTSHVSVLAKD 391

  Fly   392 GDAVSITSTINNYFGSKVASTQTGIILNDEMDDFSTPGVINGFGVPASPANYIYPGKRPMSSMSP 456
            |.||::||:|||||||.|.|..||||.||:|.||..|.:::|    .:..|.|.|||||:|||.|
Zfish   392 GSAVAVTSSINNYFGSGVMSRSTGIIFNDQMWDFIEPELMSG----PNKNNKIKPGKRPLSSMCP 452

  Fly   457 CIIV---DQEGNVRLLVGAAGGTRITTSVAAVIMKYLLRKESLTAAVNNGRLHHQLAPMRVSYEQ 518
            .||.   |::..||::||.||||.||||||.||:.:|.....|..:||..|:  |:.....:.|:
Zfish   453 TIIFEKDDRKNKVRMVVGGAGGTNITTSVAQVILNHLFFGFDLQKSVNTSRV--QITLNVTNVEK 515

  Fly   519 EVDSSVTDYLKQVGHEMYEEPVGSSFAAVTAIG 551
            :.|.:|.:.|||..|.:..:   ::.:.|.|||
Zfish   516 DFDKAVIEGLKQKNHHILHD---TALSVVQAIG 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ggt-1	NP_001285408.1	G_glu_transpept	56..566	CDD:279371	212/511 (41%)
ggt1l2.2	XP_009294029.1	G_glu_transpept	55..561	CDD:279371	212/511 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579890
Domainoid	1	1.000	396	1.000	Domainoid score	I724
eggNOG	1	0.900	-	-		E1_COG0405
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	408	1.000	Inparanoid score	I1854
OMA	1	1.010	-	-		QHG58031
OrthoDB	1	1.010	-	-		D176986at33208
OrthoFinder	1	1.000	-	-		FOG0000229
OrthoInspector	1	1.000	-	-		mtm6378
orthoMCL	1	0.900	-	-		OOG6_100578
Panther	1	1.100	-	-	O	PTHR11686
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X210
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770