DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ggt-1 and GGT5

DIOPT Version :9

Sequence 1:	NP_001285408.1	Gene:	Ggt-1 / 32839	FlyBaseID:	FBgn0030932	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	XP_011528435.1	Gene:	GGT5 / 2687	HGNCID:	4260	Length:	623	Species:	Homo sapiens

Alignment Length:	535	Identity:	187/535 - (34%)
Similarity:	267/535 - (49%)	Gaps:	55/535 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LWLLLAALMVTALTLGLVFGLKNR---DTLYISGAVVSNGIGCAAVGGEMLTDGGSAVDAAIATL 72
            |.||...|.:..:.|.:|......   ...:...||.::...|:.:|..:|...||.|||.||.|
Human    11 LVLLGLGLALAVIVLAVVLSRHQAPCGPQAFAHAAVAADSKVCSDIGRAILQQQGSPVDATIAAL 75

  Fly    73 LCEGLLLPHSMGIGGGFVATIYTRSSRKVETVIARESAPAAAHKDMFVGETSI-----TGAKSGA 132
            :|..::.|.|||:|||.:.|||..::.|||.:.|||:.| |:|....:.:.:.     |||:...
Human    76 VCTSVVNPQSMGLGGGVIFTIYNVTTGKVEVINARETVP-ASHAPSLLDQCAQALPLGTGAQWIG 139

  Fly   133 VPGEILGYWEMHRRYGILPWKRLFEPSIKLAREGHVVSRYLAAAIQSKLDNIKADPGLSA----- 192
            ||||:.||.|.|||:|.|||.:||:|:|.|.|.||||    |..:...|.|....|.|.|
Human   140 VPGELRGYAEAHRRHGRLPWAQLFQPTIALLRGGHVV----APVLSRFLHNSILRPSLQASTLRQ 200

  Fly   193 VFLNATGDPHLEGDYMKRPALADTLERIAENGAKEFYDGGETGRKFVEDIQKMGGIITEQDLRDY 257
            :|.|.| :|....|.:..||||.|||.:|..|.:.||. |..|:..||||.|.|..:|.|||
Human   201 LFFNGT-EPLRPQDPLPWPALATTLETVATEGVEVFYT-GRLGQMLVEDIAKEGSQLTLQDL--- 260

  Fly   258 TVRWESDGHVSAHVS-GTYTLYSTPMPSSGPVLAFILNLMADLYTDNEPI--------YWQRVVE 313
             .:::.:...:..|. |.|||||.|.|:.|.:|:||||::.......|.:        .:..:||
Human   261 -AKFQPEVVDALEVPLGDYTLYSPPPPAGGAILSFILNVLRGFNFSTESMARPEGRVNVYHHLVE 324

  Fly   314 AFKHAYGQRTNLGDMYADPVSAASINATLEEMLKPEFLESVRKLIHDNSTSEDYLYYGANFTVEE 378
            ..|.|.|||..||    ||.|...:.....::|.....:.:|:.| |........:|........
Human   325 TLKFAKGQRWRLG----DPRSHPKLQNASRDLLGETLAQLIRQQI-DGRGDHQLSHYSLAEAWGH 384

  Fly   379 DHGTAHMNVLATNGDAVSITSTINNYFGSKVASTQTGIILNDEMDDF---------STP------ 428
            ..||:|::||..:|.||:.|||||..||:.|.|.:||||||:|:.|.         :||
Human   385 GTGTSHVSVLGEDGSAVAATSTINTPFGAMVYSPRTGIILNNELLDLCERCPRGSGTTPSPDAVC 449

  Fly   429 GVINGFGVPASPANY--IYPGKRPMSSMSPCIIVDQEGNVRLLVGAAGGTRITTSVAAVIMKYLL 491
            ..::|..|..:|...  ..||:|..|||.|.|::::....:|::|.|||..|.::||..||..|.
Human   450 SAVSGDRVGGAPGRCWPPVPGERSPSSMVPSILINKAQGSKLVIGGAGGELIISAVAQAIMSKLW 514

  Fly   492 RKESLTAAVNNGRLH 506
            ....|.||:....||
Human   515 LGFDLRAAIAAPILH 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ggt-1	NP_001285408.1	G_glu_transpept	56..566	CDD:279371	177/487 (36%)
GGT5	XP_011528435.1	G_glu_transpept	60..618	CDD:279371	177/486 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146293
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0405
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1419292at2759
OrthoFinder	1	1.000	-	-		FOG0000229
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11686
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X210
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.810