DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ggt-1 and GGT7

DIOPT Version :9

Sequence 1:	NP_001285408.1	Gene:	Ggt-1 / 32839	FlyBaseID:	FBgn0030932	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_821158.2	Gene:	GGT7 / 2686	HGNCID:	4259	Length:	662	Species:	Homo sapiens

Alignment Length:	539	Identity:	161/539 - (29%)
Similarity:	258/539 - (47%)	Gaps:	43/539 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLLAALMVTALTLGLVFGLKNRDTLYISGAVVSNGIGCAAVGGEMLTDGGSAVDAAIATLLCEGL 77
            |..|..:..||.:.:.||   ...::..||||::...|.::|.|:|:..||:||||:|..||.|:
Human   115 LTFATGVTVALVMQIYFG---DPQIFQQGAVVTDAARCTSLGIEVLSKQGSSVDAAVAAALCLGI 176

  Fly    78 LLPHSMGIGGGFVATIYTRSSRKVETVIARESAPAAAHKDMFVGETSITGAKSGAVPGEILGYWE 142
            :.|||.|:|||.|..::.....:...:..|||||.|..::...............|||.:.|..|
Human   177 VAPHSSGLGGGGVMLVHDIRRNESHLIDFRESAPGALREETLQRSWETKPGLLVGVPGMVKGLHE 241

  Fly   143 MHRRYGILPWKRLFEPSIKLAREGHVVSRYLAAAIQSKLDNIKADPGLSAVFLNA---TGDPHLE 204
            .|:.||.|||.::...:..:|::|..|:..||.|:..:|     .|.:|..|...   :|.|.|.
Human   242 AHQLYGRLPWSQVLAFAAAVAQDGFNVTHDLARALAEQL-----PPNMSERFRETFLPSGRPPLP 301

  Fly   205 GDYMKRPALADTLERIAENGAKEFYDGGETGRKFVEDIQKMGGIITEQDLRDYTVRWESDGHVSA 269
            |..:.||.||:.|:.:..:|...||.||....:.|.:.|..||:|||:|..:|:..      |..
Human   302 GSLLHRPDLAEVLDVLGTSGPAAFYAGGNLTLEMVAEAQHAGGVITEEDFSNYSAL------VEK 360

  Fly   270 HVSGTY---TLYSTPMPSSGPVLAFILNL-----MADLYTDNEPIYWQRVVEAFKHAYGQRTNLG 326
            .|.|.|   .:.|.|.|.:||.|...||:     :..|.:..:.::|  |.|..|.|....:.||
Human   361 PVCGVYRGHLVLSPPPPHTGPALISALNILEGFNLTSLVSREQALHW--VAETLKIALALASRLG 423

  Fly   327 DMYADPVSAASINATLEEMLKPEFLESVRKLIHDNSTSEDYLYYGANFTVEEDHG---TAHMNVL 388
                |||..::|..::::||.......:|..|:|:..:...|     ..|.|..|   .|.:.::
Human   424 ----DPVYDSTITESMDDMLSKVEAAYLRGHINDSQAAPAPL-----LPVYELDGAPTAAQVLIM 479

  Fly   389 ATNGDAVSITSTINNYFGSKVASTQTGIILNDEMDDFSTPGVINGFGVPASPANYIYPGKRPMSS 453
            ..:...|::.|::|..|||.:. |.:||:||.:|.|||.|........| |..|.:.|||||:|.
Human   480 GPDDFIVAMVSSLNQPFGSGLI-TPSGILLNSQMLDFSWPNRTANHSAP-SLENSVQPGKRPLSF 542

  Fly   454 MSPCIIVDQEG--NVRLLVGAAGGTRITTSVAAVIMKYLLRKESLTAAVNNGRLHHQLAPMRVSY 516
            :.|.::...||  ...|.:||.|..|..:.:..|::..|....:|:.::..||||..|....:..
Human   543 LLPTVVRPAEGLCGTYLALGANGAARGLSGLTQVLLNVLTLNRNLSDSLARGRLHPDLQSNLLQV 607

  Fly   517 EQEVDSSVTDYLKQVGHEM 535
            :.|......::|:..||.:
Human   608 DSEFTEEEIEFLEARGHHV 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ggt-1	NP_001285408.1	G_glu_transpept	56..566	CDD:279371	149/496 (30%)
GGT7	NP_821158.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..90
GGT7	NP_821158.2	G_glu_transpept	155..654	CDD:307247	149/496 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146305
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0405
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1419292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11686
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850