Protein Alignment Pgant7 and GALNT12

DIOPT Version :10

• Sequence 1: NP_573301.2
• Gene: Pgant7 / 32836
• FlyBaseID: FBgn0030930
• Length: 591
• Species: Drosophila melanogaster
• Sequence 2: NP_078918.3
• Gene: GALNT12 / 79695
• HGNCID: 19877
• Length: 581
• Species: Homo sapiens
• Alignment Length: 613
• Identity: 222/613 - (36%)
• Similarity: 315/613 - (51%)
• Gaps: 80/613 - (13%)

  Fly     6 IRSGRICRLALCLLVLLPLLYLLANWSDHHKRVQEAYHTRFGGPKFAHQRLEGRPREVPKLVDGL 70
            :|.||     ..|||||.||.|....|     |..|......|      ..|..|...|:    .
Human    14 LRRGR-----EALLVLLALLALAGLGS-----VLRAQRGAGAG------AAEPGPPRTPR----P 58

  Fly    71 GNFEPKDVKPR-----SGPGENGEA--HSLSPDKKHMSDASEMEYGMNIACSDEISMHRSVRDTR 128
            |..||  |.||     :..|..|||  ..|..::..:.:.|...:.:||..||.||:||.:.:..
Human    59 GRREP--VMPRPPVPANALGARGEAVRLQLQGEELRLQEESVRLHQINIYLSDRISLHRRLPERW 121

  Fly   129 LEECRHWDYPFD-LPRTSVIIVFHNEGFSVLMRTVHSVIDRSPTHMLHEIILVDDFSDKENLRSQ 192
            ...|:...|.:| ||||||||.|:||.:|.|:|||:||::.||..:|.|:|||||:||:|:|:.:
Human   122 NPLCKEKKYDYDNLPRTSVIIAFYNEAWSTLLRTVYSVLETSPDILLEEVILVDDYSDREHLKER 186

  Fly   193 LDEYVLQFKGL--VKVIRNKEREGLIRTRSRGAMEATGEVIVFLDAHCEVNTNWLPPLLAPIYRD 255
            |..   :..||  |::||..:||||:|.|..||..|.|:|:.|||.|||.:..||.|||..|:.:
Human   187 LAN---ELSGLPKVRLIRANKREGLVRARLLGASAARGDVLTFLDCHCECHEGWLEPLLQRIHEE 248

  Fly   256 RTVMTVPIIDGIDHKNFEYRPVYGTDNHFRGIFEWGMLYKENEVPRREQRRRAHNSEPYRSPTHA 320
            .:.:..|:||.||...|||....|...  .|.|:|.:::..:.||.||:.|.....:..||||.|
Human   249 ESAVVCPVIDVIDWNTFEYLGNSGEPQ--IGGFDWRLVFTWHTVPERERIRMQSPVDVIRSPTMA 311

  Fly   321 GGLFAINREYFLELGAYDPGLLVWGGENFELSFKIWQCGGSIEWVPCSRVGHVYRGFMPYNFGKL 385
            |||||::::||..||:||.|:.||||||.|.||:||||||.:|..|||.||||:....||:..|.
Human   312 GGLFAVSKKYFEYLGSYDTGMEVWGGENLEFSFRIWQCGGVLETHPCSHVGHVFPKQAPYSRNKA 376

  Fly   386 ASKKKGPLITINYKRVIETWFDDTHKEYFYTREPLARYLDMGDISEQLALKKRLNCKSFQWFMDH 450
            .:         |..|..|.|.|: .||.:|.|.|.||....||::|:..|:.:|.||.|:||::.
Human   377 LA---------NSVRAAEVWMDE-FKELYYHRNPRARLEPFGDVTERKQLRDKLQCKDFKWFLET 431

  Fly   451 IAYDVY--DKFPGLPANLHWGELRSVA-SDGCLDSMGHQPP---AIMG----LTYCHGGGNNQLV 505
            :..:::  :..||.     :|.|::.. :|.|.|   :.||   .|:|    |..|||.|.||..
Human   432 VYPELHVPEDRPGF-----FGMLQNKGLTDYCFD---YNPPDENQIVGHQVILYLCHGMGQNQFF 488

  Fly   506 RLNAAGQLGVG----ERC--VEADRQGIKLAVCRLGTVDGPWQYNEHTKHLMHRVHKKCMALHPA 564
            ...:..::...    |.|  |||....:.:.:|.....:......:....|.|...|||  :..|
Human   489 EYTSQKEIRYNTHQPEGCIAVEAGMDTLIMHLCEETAPENQKFILQEDGSLFHEQSKKC--VQAA 551

  Fly   565 TQQLS------LGHCDVNDSYQQWWFKE 586
            .::.|      |..| .|..:|:|:|||
Human   552 RKESSDSFVPLLRDC-TNSDHQKWFFKE 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant7	NP_573301.2	pp-GalNAc-T	145..452	CDD:133004	138/308 (45%)
		beta-trefoil_Ricin_GALNT7	464..586	CDD:467315	35/141 (25%)
GALNT12	NP_078918.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	43..67		8/35 (23%)
		Catalytic subdomain A	135..244		59/111 (53%)
		pp-GalNAc-T	139..433	CDD:133004	138/308 (45%)
		Catalytic subdomain B	304..366		40/61 (66%)
		beta-trefoil_Ricin_GALNT12	443..579	CDD:467349	39/147 (27%)