Protein Alignment Pgant7 and GALNT8

DIOPT Version :10

• Sequence 1: NP_573301.2
• Gene: Pgant7 / 32836
• FlyBaseID: FBgn0030930
• Length: 591
• Species: Drosophila melanogaster
• Sequence 2: NP_059113.1
• Gene: GALNT8 / 26290
• HGNCID: 4130
• Length: 637
• Species: Homo sapiens
• Alignment Length: 426
• Identity: 154/426 - (36%)
• Similarity: 239/426 - (56%)
• Gaps: 31/426 - (7%)

  Fly   107 EYGMNIACSDEISMHRSVRDTRLEECRHWDYPFDLPRTSVIIVFHNEGFSVLMRTVHSVIDRSPT 171
            ::|.|...|:::.::|::.|||...|....||..||..|||::|.||..|::.|.:.|:|:|:|:
Human   146 KFGYNAYLSNQLPLNRTIPDTRDYRCLRKTYPSQLPSLSVILIFVNEALSIIQRAITSIINRTPS 210

  Fly   172 HMLHEIILVDDFSDKENLRSQLDE----YVLQFKGLVKVIRNKEREGLIRTRSRGAMEATGEVIV 232
            .:|.|||||||||....|:..|||    |..::.||:|:||:.||:||.:.|:.|...||.:|:.
Human   211 RLLKEIILVDDFSSNGELKVHLDEKIKLYNQKYPGLLKIIRHPERKGLAQARNTGWEAATADVVA 275

  Fly   233 FLDAHCEVNTNWLPPLLAPIYRDRTVMTVPIIDGIDHKNFEYRPVYGTDNHFRGI--FEWGMLYK 295
            .||||.|||..|..|:||.|..||||:..|:.|.|....|:      .|.:...:  |.|.:..:
Human   276 ILDAHIEVNVGWAEPILARIQEDRTVIVSPVFDNIRFDTFK------LDKYELAVDGFNWELWCR 334

  Fly   296 ENEVPRREQRRRAHN-SEPYRSPTHAGGLFAINREYFLELGAYDPGLLVWGGENFELSFKIWQCG 359
            .:.:|  :.....|: :.|.:||: ..|:.|.||.:..|:|:.|.|:|::||||.|||.::||||
Human   335 YDALP--QAWIDLHDVTAPVKSPS-IMGILAANRHFLGEIGSLDGGMLIYGGENVELSLRVWQCG 396

  Fly   360 GSIEWVPCSRVGHVYRGFMPYNFGKLASKKKGPLITINYKRVIETWFDD-THKEYFYTREPLARY 423
            |.:|.:||||:.|:.|...||.....|:.|:..|      ||.|.|.|: .|..|.....||...
Human   397 GKVEILPCSRIAHLERHHKPYALDLTAALKRNAL------RVAEIWMDEHKHMVYLAWNIPLQNS 455

  Fly   424 -LDMGDISEQLALKKRLNCKSFQWFMDHIAYDVYDKFPGLPANLHWGELRSVASDG-CLDSMGHQ 486
             :|.||:|.::||:::|.||:|.|::.    :||.....|...:.:|.::::..:. ||| .|..
Human   456 GIDFGDVSSRMALREKLKCKTFDWYLK----NVYPLLKPLHTIVGYGRMKNLLDENVCLD-QGPV 515

  Fly   487 PPAIMGLTYCHGGGNNQLVRLNAAGQLGVGERCVEA 522
            |.....:.||| ..::|.|..:..|:|.||:...||
Human   516 PGNTPIMYYCH-EFSSQNVYYHLTGELYVGQLIAEA 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant7	NP_573301.2	pp-GalNAc-T	145..452	CDD:133004	122/315 (39%)
		beta-trefoil_Ricin_GALNT7	464..586	CDD:467315	17/60 (28%)
GALNT8	NP_059113.1	transmembrane domain	7..29
		stem region	30..148		0/1 (0%)
		GT1 motif	182..298		53/115 (46%)
		pp-GalNAc-T	184..485	CDD:133004	122/319 (38%)
		Gal/GalNAc transferase motif	358..397		19/38 (50%)
		beta-trefoil_Ricin_GALNT8	485..629	CDD:467350	19/68 (28%)