Protein Alignment Pgant7 and GALNT15

DIOPT Version :10

• Sequence 1: NP_573301.2
• Gene: Pgant7 / 32836
• FlyBaseID: FBgn0030930
• Length: 591
• Species: Drosophila melanogaster
• Sequence 2: NP_473451.3
• Gene: GALNT15 / 117248
• HGNCID: 21531
• Length: 639
• Species: Homo sapiens
• Alignment Length: 658
• Identity: 213/658 - (32%)
• Similarity: 312/658 - (47%)
• Gaps: 114/658 - (17%)

  Fly    10 RICRLALCLLVLL---PLLYLLANWSDHH-----------KRVQEA-YHTRFG------------ 47
            |.|||...||:|:   .|:.:......||           |...|| |...||
Human    10 RPCRLQFLLLLLMLGCVLMMVAMLHPPHHTLHQTVTAQASKHSPEARYRLDFGESQDWVLEAEDE 74

  Fly    48 GPKFAHQRLEGRPREVPKLVDGL-------------------GNF--------EPKDVKPRS-GP 84
            |.:::  .|||.|..:....|.|                   |::        :.|:...|. |.
Human    75 GEEYS--PLEGLPPFISLREDQLLVAVALPQARRNQSQGRRGGSYRLIKQPRRQDKEAPKRDWGA 137

  Fly    85 GENGEAHSLSPDKKHMSDASEMEYGMNIACSDEISMHRSVRDTRLEECRHWDYPFD-LPRTSVII 148
            .|:||.    .:::.::..|....|:..|.|..|.:.|::.:.|...|.. .:|.| ||..|||:
Human   138 DEDGEV----SEEEELTPFSLDPRGLQEALSARIPLQRALPEVRHPLCLQ-QHPQDSLPTASVIL 197

  Fly   149 VFHNEGFSVLMRTVHSVIDRSPTHMLHEIILVDDFSDKENLRSQLDEYVLQFKGLVKVIRNKERE 213
            .||:|.:|.|:|||||::|..|...|.|||||||.|.:..|:|.|.|||.:.:| ||::|:.:|.
Human   198 CFHDEAWSTLLRTVHSILDTVPRAFLKEIILVDDLSQQGQLKSALSEYVARLEG-VKLLRSNKRL 261

  Fly   214 GLIRTRSRGAMEATGEVIVFLDAHCEVNTNWLPPLLAPIYRDRTVMTVPIIDGIDHKNFEYRPVY 278
            |.||.|..||..|||:|:||:|||||.:..||.|||:.|..||:.:..|:||.||.|.|:|   |
Human   262 GAIRARMLGATRATGDVLVFMDAHCECHPGWLEPLLSRIAGDRSRVVSPVIDVIDWKTFQY---Y 323

  Fly   279 GTDNHFRGIFEWGMLYKENEVPRREQRRRAHNS--EPYRSPTHAGGLFAINREYFLELGAYDPGL 341
            .:.:..||:.:|.:.:....:|  |..|:|..|  .|.|||...|.:.|::|.||...||||..:
Human   324 PSKDLQRGVLDWKLDFHWEPLP--EHVRKALQSPISPIRSPVVPGEVVAMDRHYFQNTGAYDSLM 386

  Fly   342 LVWGGENFELSFKIWQCGGSIEWVPCSRVGHVYRGFMPYNFGKLASKKKGPL---ITI-NYKRVI 402
            .:.||||.|||||.|.||||:|.:|||||||:|:.          .....||   .|: |..|:.
Human   387 SLRGGENLELSFKAWLCGGSVEILPCSRVGHIYQN----------QDSHSPLDQEATLRNRVRIA 441

  Fly   403 ETWFDDTHKEYFYTREPLARYL---DMGDISEQLALKKRLNCKSFQWFMDHIAYDVYDKFPGLPA 464
            |||. .:.||.||...|.|..|   :..|..|:|.|::||.|::|.||:.::..::|   |..|.
Human   442 ETWL-GSFKETFYKHSPEAFSLSKAEKPDCMERLQLQRRLGCRTFHWFLANVYPELY---PSEPR 502

  Fly   465 NLHWGELRSVASDGCLDSMGHQPPAIMG----LTYCHGGGNNQLVRLNAAGQLGVG---ERCVEA 522
            ....|:|.:.....|.|......  |:|    |..|......|.::..:..::..|   ..|...
Human   503 PSFSGKLHNTGLGLCADCQAEGD--ILGCPMVLAPCSDSRQQQYLQHTSRKEIHFGSPQHLCFAV 565

  Fly   523 DRQGIKLAVCRLGTVDG------PWQYNEHTKHLMHRVHKKCM--ALHPATQQLSLGHCDVNDSY 579
            .::.:.|..|   |.:|      .|.:.|:.. ::|.:..|||  .:....:.|.|..|| ..:.
Human   566 RQEQVILQNC---TEEGLAIHQQHWDFQENGM-IVHILSGKCMEAVVQENNKDLYLRPCD-GKAR 625

  Fly   580 QQWWFKEI 587
            |||.|.:|
Human   626 QQWRFDQI 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant7	NP_573301.2	pp-GalNAc-T	145..452	CDD:133004	138/315 (44%)
		beta-trefoil_Ricin_GALNT7	464..586	CDD:467315	29/136 (21%)
GALNT15	NP_473451.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	106..155		8/52 (15%)
		Catalytic subdomain A	190..299		59/109 (54%)
		pp-GalNAc-T	194..493	CDD:133004	138/315 (44%)
		Catalytic subdomain B	358..420		35/61 (57%)
		beta-trefoil_Ricin_GALNT15	502..629	CDD:467320	27/133 (20%)