Protein Alignment Mast4 and dop

DIOPT Version :9

• Sequence 1: XP_017171016.1
• Gene: Mast4 / 328329
• MGIID: 1918885
• Length: 2658
• Species: Mus musculus
• Sequence 2: NP_001261884.1
• Gene: dop / 39686
• FlyBaseID: FBgn0267390
• Length: 2139
• Species: Drosophila melanogaster
• Alignment Length: 2232
• Identity: 755/2232 - (33%)
• Similarity: 1017/2232 - (45%)
• Gaps: 688/2232 - (30%)

Mouse     1 MGEKVSEAPEPVPRGCSGHGA-----RTLVSSAAAVSSEGASSAESSSG---SETLSEEGEPSRF 57
            :|.|:|.:   .|:....|..     :::.|...|:|...::|||||||   :.|.:..|.|
  Fly    36 LGSKISTS---TPQKNDEHQEQEFINQSVASEIEAMSISDSASAESSSGATATATATMSGSP--- 94

Mouse    58 SCRSQPPRPPGGALGTRL-PAAWAPARVALERGVPTLPLPHPGGAVLPVPQVSSASQEEQDEELD 121
                .|.|....|..:|: |.:...|||.:                          .::.|:|..
  Fly    95 ----VPKRHLSTANLSRIRPQSSYSARVLI--------------------------FDDSDQEAA 129

Mouse   122 HILSPPPMPFRKCSNPDVAC-GL------------------GKSLKYKRQLSEDGKQLRRGSLGG 167
            ...:........|::...:| ||                  |.|:.....|::...    |.|.|
  Fly   130 AAAAALAAASSSCNSSVKSCSGLELLPTSPAKLSIGNDSTNGSSMMRNLNLTKSSS----GGLSG 190

Mouse   168 ALT-----GRYLLPNPVAGQAW-----PASAETSNLVRMRSQALGQSAP---------SLTASLE 213
            :.:     |...|...::.|..     ..|.|||||:|||..:||:|||         .|||.|.
  Fly   191 SSSSLHSRGYTALLRKISYQQHTNSLRAVSGETSNLLRMRHSSLGKSAPCLTGNYFRHELTAPLP 255

Mouse   214 GQPP------------------------KSHFNSARHRQRLVDPAASKKELSLPRRGSLVDSQKW 254
            .|||                        |.|.:...|              .:..|||.......
  Fly   256 VQPPGFGASPLGGHNISRSGSCAGIGLAKHHHHHHLH--------------GVVMRGSAGGGAGS 306

Mouse   255 NCLVKRCRTSNRKSLIGNGQSPAL---PRPHSPLSAHAGNSPQDSPRNFSPSASAHFSFAR---- 312
            ..........:|.||:.|..:.|.   .|.|||.||    ||.||||..||..   |:||.
  Fly   307 GGGSSSGVAHHRLSLVTNSAAVAAAGGSRTHSPYSA----SPVDSPRLNSPMP---FAFAPIKRI 364

Mouse   313 ---RNDRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQL-------------------- 354
               |....||||||:||||||||||...||.:||.|||||.|:||
  Fly   365 ASCRGVVADGRRWSVASLPSSGYGTTPGSSNLSSQCSSQEGLNQLAHNIPPGVQEADAAAVAAGA 429

Mouse   355 --------------------------PYQPTPDELH------FLSKHFCTTESI----------- 376
                                      |..|.|.:|.      ....:.|...|:
  Fly   430 CCAEHLKQHCPKHCALLLAVSQKQLTPQPPKPTQLQPQKSMTAACVNCCAELSVTCGGQQAGGGA 494

Mouse   377 ----ATENRCRNTPM----------RPRSRSL-SPGRSPACCDHEIIMMNHVYKERFPKATAQME 426
                ::.|...::.|          ||||||| ||.||| ..|:||.:||.:|||||||||.|||
  Fly   495 ANGGSSANSSGSSAMQVGGRMSPYFRPRSRSLSSPSRSP-IVDNEIAVMNTLYKERFPKATQQME 558

Mouse   427 ERLKEIITSYSPDHVLPLADG--VLSFTHHQIIELARDCLDKSHQGLITSRYFFELQHKLDKLLQ 489
            ||||..|............|.  ::.|.|||::|:|||||.||...||||:||:||...|::||.
  Fly   559 ERLKLFINENKSAACNSFRDSQPIVRFVHHQVLEMARDCLHKSEAKLITSQYFYELSENLERLLV 623

Mouse   490 EAHDRSESGELAFIKQLVRKILIVIARPARLLECLEFDPEEFYYLLEAAEGHAKEGQGIKTDIPR 554
            |..::|... .|.:..:::|:|::|:|||||||||||||:|||.||||||||||....||.|||:
  Fly   624 ETKEKSPEA-AAELNGVIKKLLLIISRPARLLECLEFDPQEFYELLEAAEGHAKAMPVIKADIPQ 687

Mouse   555 YIISQLGLNKDPLEEMAQ----------------------------------------------- 572
            |||.:||||:||:.|:.|
  Fly   688 YIIHKLGLNRDPIAELQQELRETQQMCSEQVTVDADPLHPGGSLLLNSPLTSAAKQLSSLALDAI 752

Mouse   573 LGNYDSRTA------ETP---------------EMDESVSSSNTSL------------------- 597
            ..:..|.||      :||               :|:|....|::::
  Fly   753 AMDSGSGTATPQQPPQTPVATCDTAPSFALAISQMNEEKGGSSSAVGGGSSSKVAGAEGITGGSA 817

Mouse   598 -------RLRRKPRESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFV 655
                   ..:..|:|:||:.:||||||||||||.|:||.:|||||||||||.|||||||::|.|.
  Fly   818 ATATGSGAQQPSPQENDFDIVKLISNGAYGAVYLVKHKTTRQRFAMKKINKNNLILRNQVEQVFA 882

Mouse   656 ERDILTFAENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALE 720
            |||||:||:|||||||||||||::|||:||||||||||.||:||:||||.||||.||||||||:|
  Fly   883 ERDILSFADNPFVVSMYCSFETKKHLCLVMEYVEGGDCGTLLKNIGPLPADMARFYFAETVLAVE 947

Mouse   721 YLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVCGTP 785
            |||:||||||||||||||:|::||||||||||||:||||:.||||||:|:.:.|:|.||||.|||
  Fly   948 YLHSYGIVHRDLKPDNLLITALGHIKLTDFGLSKMGLMSLATNLYEGYIDSETRQFSDKQVYGTP 1012

Mouse   786 EYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPEKDEAP-PP 849
            ||||||||||||||||||||:|||||||||:|||||||:|.||||...::|:|.||:.::.| ..
  Fly  1013 EYIAPEVILRQGYGKPVDWWSMGIILYEFLIGCVPFFGETTEELFAHTVNDDIEWPDSEDWPVQA 1077

Mouse   850 DAQELITLLLRQNPLERLGT-GGAYEVKQHRFFRSLDWNSLLRQKAEFIPQLESEDDTSYFDTRS 913
            :|:::|:.||:|||.:|||| .||.|:|:|.:|..:||||||||||||:|||..:|||||||||.
  Fly  1078 EAKDIISQLLQQNPRDRLGTQSGALEMKEHEYFLGMDWNSLLRQKAEFVPQLSHDDDTSYFDTRM 1142

Mouse   914 EKYHH-METEEEDDTNDEDFTVEIRQFSSCSHRFSKVFSSIDRITQNSGEDKDDSEDKTKSTTLP 977
            ::|:| :..|:.|||:|   |.....|:|.:.::.|...|..|      .....|.|..|.|..|
  Fly  1143 DRYNHDLGGEDTDDTDD---TPVFGSFNSYTPQYRKQHYSWSR------HATPTSTDGAKPTGPP 1198

Mouse   978 STETLSWSSEYSEMQQLSTSNSSDTESNRCKLSSGLLPKL-----------------AISTDGEQ 1025
            ...:|.     |..|:...:....|       |:|.||||                 :.|.||..
  Fly  1199 PLSSLP-----SRAQETPAATVGAT-------STGALPKLKSGMGSGSGSGSGSGSGSASHDGVV 1251

Mouse  1026 DE-----------------AVPCSGDPREEPE---------------------KPVPPSEECTQE 1052
            ::                 .||.:.|....||                     :|.|.:.:..|:
  Fly  1252 NKFLNTPQLRKLDLSSSCLKVPSTPDADYLPELLHNVTIGNDAELRMLKHYLQQPNPGATQRMQQ 1316

Mouse  1053 E----PEVTTPAST--------------ISSSTLSVGSFS------------EHLDQINGRSECV 1087
            .    |..||..||              .:..|.:|||||            :...|||.:.:.|
  Fly  1317 RHSMPPNTTTIISTPATPPPTQTQATMAATPPTATVGSFSRSTPESSQTDSDDFSPQINRKRKGV 1381

Mouse  1088 ----------------------DSTDNSSKPSSEPTSHVARQRLE---------STEKKKISGKV 1121
                                  .||:|.:.|..:  |.:|.|...         |:.|...|..:
  Fly  1382 CARDILPRFSISIEDETISAGSSSTENMNLPREQ--SPLALQHQPKSMDGSTSGSSVKHHRSRSI 1444

Mouse  1122 TKSLSASALSLM--IPGDMFAVSPLG--SPMSPHSLSSDPSSSRDSSPSRDSSAASASPHQPIVI 1182
            .||.||..||||  :.....|....|  ||....: .|..:||||:||.|:.|....:...||:|
  Fly  1445 VKSASALGLSLMTSLDNSQLAAQLCGIQSPGGGGN-GSSTASSRDTSPCRELSPLVTNLKPPIII 1508

Mouse  1183 HSSGKNYGFTIRAIRVYVGDSDIYTVHHIVWNVEEGSPAYQAGLKAGDLITHINGEPVHGLVHTE 1247
            ....:.:|||:..||||.||:|.||:||:|..|:|||||::|||:..|||||:|||.|.||.||:
  Fly  1509 RRGPRGFGFTVHTIRVYYGDTDFYTMHHLVMAVDEGSPAFEAGLRPADLITHVNGEAVQGLFHTQ 1573

Mouse  1248 VIELLLKSGNKVSITTTPFENTSIKTGPARRNSYKGRMV-----RRSKKSKKKESLERRRSLFKK 1307
            |::|||..|..|::..||.|:|||::|..:|:..:.::.     |:.|::|::...:|:.|||::
  Fly  1574 VLQLLLSGGEHVTLRATPLEHTSIQSGGRKRDLMQSKLAKKGVNRQKKQTKREHDKKRKTSLFRR 1638

Mouse  1308 LAKQPSPLLHTSRSFSCLNRSLSSGESLPGSPT-HSLSPRSPTPSYRSTPDFPSGTNSSQSSSPS 1371
            :         :|:..:...:..|:|.|.|.:|: .:|||..  .||.|:....:..:||||:|||
  Fly  1639 I---------SSKRANAEMQQYSAGTSSPTTPSARNLSPLD--SSYHSSCCQSAANSSSQSTSPS 1692

Mouse  1372 SSAPNSPAGSG-----------------------------------HI----------------- 1384
            ||:||:|.||.                                   |:
  Fly  1693 SSSPNTPTGSSGSNHGGNAGSVAVAPSALSVQLPSAPPPTQLVLLPHVGAVVGSNPTSVGNVPVS 1757

Mouse  1385 ----------RPSTLHGLAPKL-------------------------SGQRYRSGRRKSAGSIPL 1414
                      ||||||||..||                         :.......||||.|.|||
  Fly  1758 PTGVVPQLYQRPSTLHGLKHKLHAATAVIAGGGNANNPAGGLKTLHTTNNNSLPNRRKSVGHIPL 1822

Mouse  1415 SPLARTPSPTPQPTSPQRSPS----PLLGHSLGNAKITQAFPSKMHSP----PTIVRHI------ 1465
            |||||||||:|.|:||.||||    ||:||..|.:..||::     ||    ||:...:
  Fly  1823 SPLARTPSPSPLPSSPTRSPSPLAFPLVGHQPGASNTTQSY-----SPGSTLPTLQTAVNANTKK 1882

Mouse  1466 ---VRPKSAEPPRSPLLKRVQSEEKLSPSYGSDK--KLLCSRKHSLEVTQEEVQREQCQREVT-- 1523
               .|.|||| |.||||:|..|.::|.|.....|  .|.||         ..:::...||.||
  Fly  1883 AGFARTKSAE-PSSPLLRRALSPDRLHPRSAETKISPLCCS---------PPIKQPTHQRVVTTT 1937

Mouse  1524 --------LQSLEENVCDAPSLSRARPVEQGCLKRPVSRKVGRQESVDDLDRDKLKAKVVVKKPE 1580
                    .......|..|||:   :|::   |....|.:..||.::         |.||
  Fly  1938 WRSTPGGSASGAGGAVLGAPSV---QPLQ---LVPAASEESQRQTAM---------ATVV----- 1982

Mouse  1581 EKHESHQKPHSLGGDSESYALFRL----------EEREKKV-----------YSKGLERSGHFEN 1624
                   ...:.|.|..:.|:..|          ||::...           :...:|.....|:
  Fly  1983 -------STTAAGTDPSATAVVTLANCEPLPRIAEEKDSPTSTQDSSSVSEGFMPAIEEFAEGES 2040

Mouse  1625 TSAELPSVGSLLKDTLHKQASVRASEGVTSDGAACS--------LTPG-----EHSQ----SLGD 1672
            :|:  |:      .||.|...|:|:|....:.|..|        .|||     .|:.    |:..
  Fly  2041 SSS--PT------QTLEKPTKVKATEQPEMEPAGKSKKVDQGKTTTPGTPKTKPHNSGCKTSMTT 2097

Mouse  1673 FKRASASGILHDSVCPISDRPA 1694
            .|.||.|..:  |..|..|..|
  Fly  2098 TKPASPSVTI--STAPRKDTSA 2117

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mast4	XP_017171016.1	DUF1908	293..569	CDD:370192	151/362 (42%)
		STKc_MAST	607..886	CDD:270760	204/280 (73%)
		PDZ_signaling	1184..1262	CDD:238492	43/77 (56%)
dop	NP_001261884.1	DUF1908	344..702	CDD:286070	151/362 (42%)
		STKc_MAST	834..1115	CDD:270760	204/280 (73%)
		S_TKc	835..1110	CDD:214567	202/274 (74%)
		PDZ_signaling	1506..1587	CDD:238492	45/80 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844254
Domainoid	1	1.000	440	1.000	Domainoid score	I547
eggNOG	1	0.900	-	-		E1_KOG0606
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	994	1.000	Inparanoid score	I304
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164781at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43472
orthoMCL	1	0.900	-	-		OOG6_100724
Panther	1	1.100	-	-	O	PTHR24356
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3124
SonicParanoid	1	1.000	-	-		X479
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.880