Protein Alignment Hayan and LPA

DIOPT Version :10

• Sequence 1: NP_001097020.1
• Gene: Hayan / 32831
• FlyBaseID: FBgn0030925
• Length: 637
• Species: Drosophila melanogaster
• Sequence 2: NP_005568.2
• Gene: LPA / 4018
• HGNCID: 6667
• Length: 2040
• Species: Homo sapiens
• Alignment Length: 726
• Identity: 167/726 - (23%)
• Similarity: 237/726 - (32%)
• Gaps: 256/726 - (35%)

  Fly   113 TPEPEPLPPT---TTEGKRERESRLD-----ENQNFFDFNKLLSTTV--------KPQKTHESLK 161
            ||...|:|.|   :.|...|..:.:.     :.|:   :...||||:        .....|...:
Human  1361 TPTVVPVPSTELPSEEAPTENSTGVQDCYRGDGQS---YRGTLSTTITGRTCQSWSSMTPHWHRR 1422

  Fly   162 LP--------TQESMKTPTHE------------------SMKMPTHESMKLPTHEPMKLPIQSVG 200
            :|        |:...:.|..|                  ..:.|..||..|.|  |...|:.|..
Human  1423 IPLYYPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTRCPVTESSVLTT--PTVAPVPSTE 1485

  Fly   201 AWGIAPSKTQP--------------------IAST--------QRSFMEPEWGREPRIVNRPLTT 237
                |||:..|                    |:||        ..|.|.|.|.:.         |
Human  1486 ----APSEQAPPEKSPVVQDCYHGDGRSYRGISSTTVTGRTCQSWSSMIPHWHQR---------T 1537

  Fly   238 PRSRPQRPNNSNFNTNPSPNNNNLIHLVNDRLREQGMQIEPAREVPMVLQTTPTPTPAPT----- 297
            |.:.|......|:..||........:..:..:|.:...:....|....:..|||..|.|:
Human  1538 PENYPNAGLTENYCRNPDSGKQPWCYTTDPCVRWEYCNLTQCSETESGVLETPTVVPVPSMEAHS 1602

  Fly   298 ---PTQLIDPF-EPYRFRGQD-----------------------RDKDTQPQEPWND-----VSN 330
               ||:..... :.|...||.                       |.:.|....| ||     ...
Human  1603 EAAPTEQTPVVRQCYHGNGQSYRGTFSTTVTGRTCQSWSSMTPHRHQRTPENYP-NDGLTMNYCR 1666

  Fly   331 NLDADPAPSIF--NP------------AETRPTTPNPNPSRVNLPEKERPSVAAC----EKIRSG 377
            |.|||..|..|  :|            ::|..|...| |:.:.:|....||...|    .|...|
Human  1667 NPDADTGPWCFTMDPSIRWEYCNLTRCSDTEGTVVAP-PTVIQVPSLGPPSEQDCMFGNGKGYRG 1730

  Fly   378 GKPLTV---------------H--ILDGERVDRGV---------------------------YPH 398
            .|..||               |  .:.|.....|:                           |..
Human  1731 KKATTVTGTPCQEWAAQEPHRHSTFIPGTNKWAGLEKNYCRNPDGDINGPWCYTMNPRKLFDYCD 1795

  Fly   399 MAAIAYNSF-------------GS---------------AAFR-------CGGSLIASRFVLTAA 428
            :...|.:||             ||               .:.|       |||:||:..:|||||
Human  1796 IPLCASSSFDCGKPQVEPKKCPGSIVGGCVAHPHSWPWQVSLRTRFGKHFCGGTLISPEWVLTAA 1860

  Fly   429 HCVNSDDSTPSF-VRLGALNIENPEPGYQDINVIDVQIHPDYSGSSKYYDIAILQLAEDAKESDV 492
            ||:.......|: |.|||....|.|...|:|.|..:.:.|..:      |||:|:|:..|..:|.
Human  1861 HCLKKSSRPSSYKVILGAHQEVNLESHVQEIEVSRLFLEPTQA------DIALLKLSRPAVITDK 1919

  Fly   493 IRPACLYTDRSDPPANYKYFVAGWGVMNVTNRAVSKILLRAALDLVPADE-CNASFAEQPSANRT 556
            :.||||.:......|..:.::.|||   .|.......||:.|..||..:| ||.
Human  1920 VMPACLPSPDYMVTARTECYITGWG---ETQGTFGTGLLKEAQLLVIENEVCNH----------- 1970

  Fly   557 LRRGVIASQLCAADKNQRKDACQGDSGGPLILEIDDVDGTYSIVGVISSGFGCA-TKTPGLYTRV 620
                  ...:||....:..|:|||||||||:....|   .|.:.||.|.|.||| ...||:|.||
Human  1971 ------YKYICAEHLARGTDSCQGDSGGPLVCFEKD---KYILQGVTSWGLGCARPNKPGVYARV 2026

  Fly   621 SSFLDYIEGIV 631
            |.|:.:|||::
Human  2027 SRFVTWIEGMM 2037

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hayan	NP_001097020.1	CLIP	32..80	CDD:197829
		Tryp_SPc	385..630	CDD:238113	86/309 (28%)
LPA	NP_005568.2	Kringle	28..105	CDD:395005
		Kringle	142..219	CDD:395005
		Kringle	256..333	CDD:395005
		Kringle	370..447	CDD:395005
		Kringle	484..561	CDD:395005
		Kringle	598..675	CDD:395005
		Kringle	712..789	CDD:395005
		Kringle	826..903	CDD:395005
		KR	938..1019	CDD:214527
		Kringle	1054..1131	CDD:395005
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1147..1166
		KR	1166..1246	CDD:214527
		KR	1272..1352	CDD:214527
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1365..1388		5/22 (23%)
		KR	1386..1466	CDD:214527	10/82 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1476..1497		7/24 (29%)
		KR	1500..1581	CDD:214527	14/89 (16%)
		KR	1614..1695	CDD:214527	15/81 (19%)
		Kringle	1720..1799	CDD:395005	10/78 (13%)
		Tryp_SPc	1820..2034	CDD:238113	76/242 (31%)