Protein Alignment Hayan and TMPRSS12

DIOPT Version :10

• Sequence 1: NP_001097020.1
• Gene: Hayan / 32831
• FlyBaseID: FBgn0030925
• Length: 637
• Species: Drosophila melanogaster
• Sequence 2: NP_872365.2
• Gene: TMPRSS12 / 283471
• HGNCID: 28779
• Length: 348
• Species: Homo sapiens
• Alignment Length: 327
• Identity: 89/327 - (27%)
• Similarity: 146/327 - (44%)
• Gaps: 56/327 - (17%)

  Fly   329 SNNLDADPAPSIFNPAETRPTTPNPNPSRVNLPEKERPSVAACEKIR-----------SGGKPLT 382
            |::|.:|.    ::|:......|:|.|:     ...:.:.|..:::|           .|..||.
Human    15 SSHLYSDH----YSPSGRHRLGPSPEPA-----ASSQQAEAVRKRLRRRREGGAHAEDCGTAPLK 70

  Fly   383 VHILDGERV------DRGVYPHMAAIAYNSFGSAAFRCGGSLIASRFVLTAAHCVNSDDSTPSF- 440
             .:|.|.|:      ..|.:|.:.::...........|||:|:..|:||||||| ..|.|.|..
Human    71 -DVLQGSRIIGGTEAQAGAWPWVVSLQIKYGRVLVHVCGGTLVRERWVLTAAHC-TKDASDPLMW 133

  Fly   441 -VRLGALNIENPEPGYQDINVIDVQIHPDYSGSSKYYDIAILQLAEDAKESDVIRPACLYTDRSD 504
             ..:|..||....|..:.|.:..:.|||::...|...|||:..|.:..:.:|.|:|.||..|...
Human   134 TAVIGTNNIHGRYPHTKKIKIKAIIIHPNFILESYVNDIALFHLKKAVRYNDYIQPICLPFDVFQ 198

  Fly   505 -PPANYKYFVAGWGVM----NVTNRAVSKILLRAALDLVPADECNA--SFAEQPSANRTLRRGVI 562
             ...|.|.|::|||..    |.||     ||..|.:..:..:.||:  |:.           |:|
Human   199 ILDGNTKCFISGWGRTKEEGNATN-----ILQDAEVHYISREMCNSERSYG-----------GII 247

  Fly   563 A-SQLCAADKNQRKDACQGDSGGPLILEIDDVDGTYSIVGVISSGFGCATK-TPGLYTRVSSFLD 625
            . :..||.|::...|.|:|||||||:..:.:.. .:.::|:.|.|.||..: .||:|...|.:..
Human   248 PNTSFCAGDEDGAFDTCRGDSGGPLMCYLPEYK-RFFVMGITSYGHGCGRRGFPGVYIGPSFYQK 311

  Fly   626 YI 627
            ::
Human   312 WL 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hayan	NP_001097020.1	CLIP	32..80	CDD:197829
		Tryp_SPc	385..630	CDD:238113	77/260 (30%)
TMPRSS12	NP_872365.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..46		4/26 (15%)
		Tryp_SPc	78..316	CDD:238113	74/254 (29%)