DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hayan and svh-1

DIOPT Version :9

Sequence 1:	NP_001097020.1	Gene:	Hayan / 32831	FlyBaseID:	FBgn0030925	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_501379.2	Gene:	svh-1 / 182375	WormBaseID:	WBGene00006620	Length:	951	Species:	Caenorhabditis elegans

Alignment Length:	719	Identity:	156/719 - (21%)
Similarity:	254/719 - (35%)	Gaps:	201/719 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 DEGDPCQVRS---DIPGICLSSS-ACE------------NIRGYLKSGTLSTS------------ 63
            :.||.|.:.|   |....|:|.. .|:            |...||:...|..:
Worm   315 ESGDSCPIGSISCDNGSKCISEKFQCDYEVDCNDGSDEHNCEDYLQYYELIGAYRLADNIIEVWT 379

  Fly    64 ---QVPSCGFGAREEIICCPTVA-------CCATDRGREVQFHATSSERSSLPEPKREPTPEPEP 118
               .|..|....||.::.|...:       |..||..:  .|.:.:.:.:||...:|..|.:.|
Worm   380 FIPHVQGCARKCRESLLMCEAFSYEPKSQTCLLTDTSQ--TFSSLARKITSLYYRRRFSTKDVE- 441

  Fly   119 LPPTTTEGK-------RERESRLDENQNFFDFNKLLST-----------TVKPQKTHESLKLPTQ 165
               ...|.|       .::....|:|   :...||.|.           ||:..::..||. |.|
Worm   442 ---FQVENKVLYATKSAKKGHVCDDN---YSREKLSSICRVLGFGDPIYTVESHQSESSLG-PLQ 499

  Fly   166 ESMKTPTHESMKMPTHESMKLPTHEPMKLPIQSVGAWGIA----PSKTQPIAST----------Q 216
            .:...||:.|...|:..|....| .|.......:.||.::    |:.|..:.||          |
Worm   500 PTTLHPTNPSFDSPSSVSQMRRT-SPSATLAPRLPAWNLSCLREPNCTSTVISTCEPIRCSHCQQ 563

  Fly   217 RSFMEPEWGREPRIVNRPLTTPRSRPQ---RPNNSNFNTNPSPN--------------------N 258
            .:..:....|..::.|..:.......:   |.|:... ||.|..                    |
Worm   564 AACGDGSCIRFDQLCNGQIDCQSGEDEDYCRANSFRL-TNGSDTSGYLEVLFRSRWEPICADHLN 627

  Fly   259 NNLIHLVND--RLREQGMQIEPAREVPMVLQTTPTPTPAPTPTQLIDPFEPYRFRGQDRDKDTQP 321
            ..:.:.:.|  ||.|.|          .:|.|..|
Worm   628 GKISNSICDAMRLGEHG----------FILSTNAT------------------------------ 652

  Fly   322 QEPWNDVSN--NLDADPAPSIFNPAETRPTTPNPNPSRVN-LPEKERPSVAAC------EKIRSG 377
                  :|:  |::.|...||      |.::.....:|:: :.:....|.:.|      ...|..
Worm   653 ------ISSGYNVNCDVDCSI------RRSSSCTRHARISCISQNGMSSASQCGLRYVEVNARDA 705

  Fly   378 GKPLTVHILDGERVDRGVYPHMAAIAYNSFGSAAFRCGGSLIASRFVLTAAHCVNSDDSTPSF-V 441
            .|.....::.|.....|.:|..||:  .:..:.|..||.|::....::|||||...|:...|: |
Worm   706 AKSRIARVVGGFETVPGAFPWTAAL--RNKATKAHHCGASILDKTHLITAAHCFEEDERVSSYEV 768

  Fly   442 RLGALNIENPEPGYQDINVID-VQIHPDYSGSSKYYDIAILQLAEDAKE-SDVIRPACLYTDRSD 504
            .:|..: .|...|.:.|..:. :..:|.|..... :|||||::.....| ::..:|.||
Worm   769 VVGDWD-NNQTDGNEQIFYLQRIHFYPLYKDIFS-HDIAILEIPYPGIEFNEYAQPICL------ 825

  Fly   505 PPANYKY------FVAGWGVMNVTNRAVSKILLRAALDLVPADECNASFAEQPSANRTLRRGVIA 563
            |..::.|      .|:|||.|.:   ..::.|..|.:.::...:|..|.....|.:|
Worm   826 PSKDFVYTPGRQCVVSGWGSMGL---RYAERLQAALIPIINRFDCVNSSQIYSSMSR-------- 879

  Fly   564 SQLCAADKNQRKDACQGDSGGPLILEIDDVDGTYSIVGVISSGFGCA-TKTPGLYTRVSSFLDYI 627
            |..||.......|:||||||||.....:  ||.:.:.||||.|.||| .|.||:||.|:.:|.:|
Worm   880 SAFCAGYLEGGIDSCQGDSGGPFACRRE--DGAFVLAGVISWGDGCAQKKQPGIYTMVAPYLSWI 942

  Fly   628 EGIV 631
            ..|:
Worm   943 SAII 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hayan	NP_001097020.1	CLIP	32..80	CDD:197829	14/78 (18%)
		Tryp_SPc	384..627	CDD:214473	74/252 (29%)
		Tryp_SPc	385..630	CDD:238113	75/254 (30%)
svh-1	NP_501379.2	KR	227..306	CDD:214527
		LDLa	320..355	CDD:238060	6/34 (18%)
		PAN_AP_HGF	373..434	CDD:238532	11/62 (18%)
		LDLa	558..590	CDD:197566	3/31 (10%)
		SRCR_2	599..681	CDD:382996	19/134 (14%)
		Tryp_SPc	713..945	CDD:238113	75/254 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910