DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15056 and KDM2B

DIOPT Version :9

Sequence 1:	NP_573291.1	Gene:	CG15056 / 32824	FlyBaseID:	FBgn0030918	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	XP_011537169.1	Gene:	KDM2B / 84678	HGNCID:	13610	Length:	1353	Species:	Homo sapiens

Alignment Length:	267	Identity:	60/267 - (22%)
Similarity:	97/267 - (36%)	Gaps:	105/267 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 FSNLTY----VSLRRCQ-----LNDENLVGWEFLTHLETLDLRYNDRLTGSCLMSL----PTSL- 180
            ||.|::    |.:|.|:     ..|:.|  |      ..:||.:...:|...|..:    |.||
Human  1077 FSYLSHQDLCVCMRVCRTWNRWCCDKRL--W------TRIDLNHCKSITPLMLSGIIRRQPVSLD 1133

  Fly   181 LSLYITGCRNLCPNQLIFL-NRIPRLRELRASDLMPGGHWHIYRDLVLACPLLVMVEIS-ICSLN 243
            ||     ..|:...||.:| ||:|.||:|    ::.|..|               :.:| :||
Human  1134 LS-----WTNISKKQLSWLINRLPGLRDL----VLSGCSW---------------IAVSALCS-- 1172

  Fly   244 RDEYRLGELRYLQSLVIKAHSTDTIRCKVSDWMLISLLDVPFLRNLMFSDAPSGFVSANALSIIS 308
                                         |...|:..|||.::..|  .||
Human  1173 -----------------------------SSCPLLRTLDVQWVEGL--KDA-------------- 1192

  Fly   309 RFRQLRVLKMP---NQPYRPNDLLRLRNLTFLETLDLSNSPYITNEVVIELVIGIPNLSVLIVQG 370
               |:|.|..|   |:|.:.::..:|||:..|....|.    ||:..:..::..:|.||.|.:..
Human  1193 ---QMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLD----ITDASLRLIIRHMPLLSKLHLSY 1250

  Fly   371 CPLLTNR 377
            |..:|::
Human  1251 CNHVTDQ 1257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15056	NP_573291.1	leucine-rich repeat	133..156	CDD:275381	7/31 (23%)
		leucine-rich repeat	157..179	CDD:275381	5/25 (20%)
		leucine-rich repeat	180..204	CDD:275381	9/25 (36%)
		leucine-rich repeat	205..231	CDD:275381	5/25 (20%)
		leucine-rich repeat	232..285	CDD:275381	8/53 (15%)
		leucine-rich repeat	286..326	CDD:275381	9/42 (21%)
		AMN1	306..>376	CDD:187754	18/72 (25%)
		leucine-rich repeat	337..362	CDD:275381	4/24 (17%)
KDM2B	XP_011537169.1	JmjC	182..257	CDD:214721
		cupin_like	229..335	CDD:304367
		zf-CXXC	<615..651	CDD:251032
		PHD_KDM2B	661..722	CDD:277114
		F-box-like	1071..1111	CDD:289689	10/41 (24%)
		leucine-rich repeat	1105..1129	CDD:275381	5/29 (17%)
		AMN1	1121..1310	CDD:187754	48/215 (22%)
		leucine-rich repeat	1130..1153	CDD:275381	10/27 (37%)
		leucine-rich repeat	1154..1177	CDD:275381	9/72 (13%)
		leucine-rich repeat	1178..1217	CDD:275381	13/57 (23%)
		leucine-rich repeat	1218..1242	CDD:275381	4/27 (15%)
		leucine-rich repeat	1243..1272	CDD:275381	5/15 (33%)
		leucine-rich repeat	1273..1297	CDD:275381
		leucine-rich repeat	1298..1323	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900