Protein Alignment CG15056 and SKP2

DIOPT Version :10

• Sequence 1: NP_573291.1
• Gene: CG15056 / 32824
• FlyBaseID: FBgn0030918
• Length: 399
• Species: Drosophila melanogaster
• Sequence 2: NP_005974.2
• Gene: SKP2 / 6502
• HGNCID: 10901
• Length: 424
• Species: Homo sapiens
• Alignment Length: 243
• Identity: 50/243 - (20%)
• Similarity: 89/243 - (36%)
• Gaps: 74/243 - (30%)

  Fly    88 PMFSHFEDF-IRLMSI---------------RLTKVNEIALEGFQL------TQYKWFNAPETSF 130
            |:..||..| ::.|.:               :.:|:..::|||.:|      |..|..|....:.
Human   173 PLAEHFSPFRVQHMDLSNSVIEVSTLHGILSQCSKLQNLSLEGLRLSDPIVNTLAKNSNLVRLNL 237

  Fly   131 SNLTYVS-------LRRCQLNDENLVGWEFLTHLETLDLRYNDRLTGSCLMSLPTSLLSLYITGC 188
            |..:..|       |..|...||..:.|.|         .:.::.....:..:..::..|.::|.
Human   238 SGCSGFSEFALQTLLSSCSRLDELNLSWCF---------DFTEKHVQVAVAHVSETITQLNLSGY 293

  Fly   189 RNLCPNQLIFLNRIPRLRELRASDLMPGGHWHIYRDLVLACPLLVMVEISICSLNRDE--YRLGE 251
            |                :.|:.|||         ..||..||.||.:::|...:.:::  ....:
Human   294 R----------------KNLQKSDL---------STLVRRCPNLVHLDLSDSVMLKNDCFQEFFQ 333

  Fly   252 LRYLQSLVIKAHSTDTIRC-KVSDWMLISLLDVPFLRNL-MFSDAPSG 297
            |.|||.|.:.       || .:....|:.|.::|.|:.| :|...|.|
Human   334 LNYLQHLSLS-------RCYDIIPETLLELGEIPTLKTLQVFGIVPDG 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15056	NP_573291.1	leucine-rich repeat	133..156	CDD:275381	7/29 (24%)
		leucine-rich repeat	157..179	CDD:275381	0/21 (0%)
		leucine-rich repeat	180..204	CDD:275381	3/23 (13%)
		leucine-rich repeat	205..231	CDD:275381	7/25 (28%)
		leucine-rich repeat	232..285	CDD:275381	12/55 (22%)
		leucine-rich repeat	286..326	CDD:275381	5/13 (38%)
		AMN1	306..>376	CDD:187754
		leucine-rich repeat	337..362	CDD:275381
SKP2	NP_005974.2	Mediates interaction with hepatitis C virus non-structural protein NS5A. /evidence=ECO:0000269|PubMed:27194766	1..220		10/46 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	39..73
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:22770219	67..73
		F-box_FBXL1	97..137	CDD:438886
		leucine-rich repeat	183..207	CDD:275381	1/23 (4%)
		AMN1	193..>345	CDD:187754	35/192 (18%)
		leucine-rich repeat	208..231	CDD:275381	6/22 (27%)
		LRR 3. /evidence=ECO:0000269|PubMed:11099048	210..234		7/23 (30%)
		leucine-rich repeat	232..257	CDD:275381	4/24 (17%)
		LRR 4. /evidence=ECO:0000269|PubMed:11099048	235..257		4/21 (19%)
		leucine-rich repeat	258..284	CDD:275381	4/34 (12%)
		LRR 5. /evidence=ECO:0000269|PubMed:11099048	258..284		4/34 (12%)
		leucine-rich repeat	285..311	CDD:275381	10/50 (20%)
		LRR 6. /evidence=ECO:0000269|PubMed:11099048	286..308		9/46 (20%)
		LRR 7. /evidence=ECO:0000269|PubMed:11099048	309..330		5/20 (25%)
		leucine-rich repeat	312..336	CDD:275381	4/23 (17%)
		LRR 8. /evidence=ECO:0000269|PubMed:11099048	334..356		8/28 (29%)
		leucine-rich repeat	337..356	CDD:275381	6/25 (24%)
		LRR 9. /evidence=ECO:0000269|PubMed:11099048	359..378		6/16 (38%)
		leucine-rich repeat	365..392	CDD:275381	4/10 (40%)
		LRR 10. /evidence=ECO:0000269|PubMed:11099048	380..401
		Mediates interaction with IFI27. /evidence=ECO:0000269|PubMed:27194766	402..424