Protein Alignment CG15056 and FBXL17

DIOPT Version :9

• Sequence 1: NP_573291.1
• Gene: CG15056 / 32824
• FlyBaseID: FBgn0030918
• Length: 399
• Species: Drosophila melanogaster
• Sequence 2: XP_005272105.1
• Gene: FBXL17 / 64839
• HGNCID: 13615
• Length: 712
• Species: Homo sapiens
• Alignment Length: 450
• Identity: 86/450 - (19%)
• Similarity: 156/450 - (34%)
• Gaps: 157/450 - (34%)

  Fly     4 ISFSVISRF------DF-FWLDVLKQLDLKSRISFAASCDMFENIYVRSSPLRLSRVVNLEEMIE 61
            :|.|::.::      || ||    |||||.||..  .:.::.|.|..||           :.:||
Human   343 LSASLVCKYWRDLCLDFQFW----KQLDLSSRQQ--VTDELLEKIASRS-----------QNIIE 390

  Fly    62 FSLLETK---------LFVELSG------------SDIEIIRGGPHTPMFS-------------- 91
            .::.:.:         |..:..|            ||..||....|.|:..
Human   391 INISDCRSMSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEG 455

  Fly    92 --------------HF-------EDFIRLMSIRLTKVNEIALEGFQLTQYKWFNAPETSFSNLTY 135
                          ||       ::.:.:::....|:..|.::..:|...:...|.......|.|
Human   456 LKQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQY 520

  Fly   136 VSLRRCQLNDENLVGWEFLTHLETLDLRYNDRLTGSCLMSLPTSLLSLYITGCRNLCPNQLIFLN 200
            |....|.:..:.::....|.:|.:||||:...|....:|.:        :..|:||....|..
Human   521 VGFMGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEI--------VKRCKNLSSLNLCL-- 575

  Fly   201 RIPRLRELRASDLMPGGHWHIYRDLVLACPLLVMVEISICSLNRDEYRLGELRYLQSLVIKAHST 265
                             :| |..|   .|     ||:    :.::...|.|| ||
Human   576 -----------------NW-IIND---RC-----VEV----IAKEGQNLKEL-YL---------- 599

  Fly   266 DTIRCKVSDWMLISL---------LDVPFLRNLMFSDAPSGFVSANALSI----ISRFRQLRVLK 317
              :.||::|:.||::         :||.:.:.:  :|..:..::.::.|:    :.|..::||
Human   600 --VSCKITDYALIAIGRYSMTIETVDVGWCKEI--TDQGATLIAQSSKSLRYLGLMRCDKVRV-- 658

  Fly   318 MPNQPYRPNDLLRLRNLTFLETLDLSNSPYITNEVVIELVIGIPNLSVLIVQGC-PLLTN 376
                .|:....|.:..:..|.:..||.|  |:..|...|.|....:..:|...| |...|
Human   659 ----DYQVVCFLHISIVNSLMSYPLSFS--ISTPVYYILYIHFICIYAIIAMHCLPAFVN 712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15056	NP_573291.1	leucine-rich repeat	133..156	CDD:275381	5/22 (23%)
		leucine-rich repeat	157..179	CDD:275381	7/21 (33%)
		leucine-rich repeat	180..204	CDD:275381	4/23 (17%)
		leucine-rich repeat	205..231	CDD:275381	4/25 (16%)
		leucine-rich repeat	232..285	CDD:275381	14/61 (23%)
		leucine-rich repeat	286..326	CDD:275381	6/43 (14%)
		AMN1	306..>376	CDD:187754	16/74 (22%)
		leucine-rich repeat	337..362	CDD:275381	8/24 (33%)
FBXL17	XP_005272105.1	F-box-like	321..368	CDD:289689	10/28 (36%)
		leucine-rich repeat	362..387	CDD:275381	12/41 (29%)
		leucine-rich repeat	388..413	CDD:275381	3/24 (13%)
		AMN1	411..573	CDD:187754	28/169 (17%)
		leucine-rich repeat	414..439	CDD:275381	5/24 (21%)
		leucine-rich repeat	440..465	CDD:275381	0/24 (0%)
		leucine-rich repeat	466..491	CDD:275381	2/24 (8%)
		leucine-rich repeat	492..517	CDD:275381	3/24 (13%)
		leucine-rich repeat	518..541	CDD:275381	5/22 (23%)
		leucine-rich repeat	542..567	CDD:275381	8/32 (25%)
		AMN1	547..>652	CDD:187754	28/159 (18%)
		leucine-rich repeat	568..593	CDD:275381	8/56 (14%)
		leucine-rich repeat	594..615	CDD:275381	10/33 (30%)
		leucine-rich repeat	619..641	CDD:275381	3/23 (13%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153039
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.830