DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15056 and FBXL19

DIOPT Version :9

Sequence 1:	NP_573291.1	Gene:	CG15056 / 32824	FlyBaseID:	FBgn0030918	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_001093254.2	Gene:	FBXL19 / 54620	HGNCID:	25300	Length:	694	Species:	Homo sapiens

Alignment Length:	229	Identity:	54/229 - (23%)
Similarity:	80/229 - (34%)	Gaps:	85/229 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ISFSVISRFDFFW----LDVLKQLDLKSRISFAASCDMFENIYVRSSPLRLSRVVNLE--EMIEF 62
            :|::.:|:....|    |..|::|.|       :.|.......:.|:||...|:::|.  |.::.
Human   490 LSWTGVSKKQLMWLLNRLQGLQELVL-------SGCSWLSVSALGSAPLPALRLLDLRWIEDVKD 547

  Fly    63 SLLETKLFVELSGSDIEIIRGGPHT-PMFSHFEDFIRLMSIRLTKVNEIALEGFQLTQYKWFNAP 126
            |.|.            |::...|.| |..:....       ||..|.|:.|.|.:||.
Human   548 SQLR------------ELLLPPPDTKPGQTESRG-------RLQGVAELRLAGLELTD------- 586

  Fly   127 ETSFSNLTYVSLRRCQLNDENLVGWEFLTH---LETLDLRYNDRLTGSC---------LMSLPTS 179
                     .|||.            .|.|   |..|||.:       |         |::.|||
Human   587 ---------ASLRL------------LLRHAPQLSALDLSH-------CAHVGDPSVHLLTAPTS 623

  Fly   180 -----LLSLYITGCRNLCPNQLIFLNRIPRLREL 208
                 |:.|.:.||..|..:.|....|.||||.|
Human   624 PLRETLVHLNLAGCHRLTDHCLPLFRRCPRLRRL 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15056	NP_573291.1	leucine-rich repeat	133..156	CDD:275381	4/22 (18%)
		leucine-rich repeat	157..179	CDD:275381	7/30 (23%)
		leucine-rich repeat	180..204	CDD:275381	7/23 (30%)
		leucine-rich repeat	205..231	CDD:275381	3/4 (75%)
		leucine-rich repeat	232..285	CDD:275381
		leucine-rich repeat	286..326	CDD:275381
		AMN1	306..>376	CDD:187754
		leucine-rich repeat	337..362	CDD:275381
FBXL19	NP_001093254.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		zf-CXXC	<50..77	CDD:251032
		PHD_FXL19	87..148	CDD:277115
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..420
		F-box-like	424..465	CDD:315592
		leucine-rich repeat	461..485	CDD:275381
		AMN1	466..665	CDD:332986	54/229 (24%)
		leucine-rich repeat	486..508	CDD:275381	3/17 (18%)
		LRR 1	492..517		6/31 (19%)
		leucine-rich repeat	510..533	CDD:275381	7/29 (24%)
		LRR 2	518..541		6/22 (27%)
		leucine-rich repeat	534..573	CDD:275381	11/57 (19%)
		leucine-rich repeat	574..598	CDD:275381	11/51 (22%)
		LRR 3	581..606		12/52 (23%)
		leucine-rich repeat	599..623	CDD:275381	7/30 (23%)
		LRR 4	607..636		7/28 (25%)
		leucine-rich repeat	629..653	CDD:275381	7/23 (30%)
		LRR 5	637..661		9/21 (43%)
		leucine-rich repeat	654..686	CDD:275381	3/4 (75%)
		LRR 6	662..694
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153074
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930